Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...lf, turning off the unrestrained multiplication of cancer cells. The study also shows that a slight change i... of the NEDD8 pathway to accelerate replication of cancer cells." The extensive study required a variety of techniques to tease apart the structure formed by ...Charting the future in prostate cancer care: A call to action
...imated 230,000 men will be diagnosed with prostate cancer in the United States, and 30,000 are expected to d... beginning at age 50, this disease will become the cancer with the greatest increase in incidence, in addition to being the most common non-skin cancer in the...The search for a kinder, gentler chemotherapy
...ped nano-sized particles that can target and trick cancer cells into absorbing them. Once inside, the partic...cific kind of chemistry that allows them to target cancer cells," said L. Andrew Lyon, associate professor at Georgia Tech's School of Chemistry and Biochemis...NJIT professor receives Presidential Award for breakthrough research with adult stem cells
.... Stem cell implantation, for instance, could help cancer patients who've had large tumors removed from bone, Arinzeh says. In many such surgeries, patients lose their limbs. But if her method of implanting stem cells mixed with biomaterials is shown to induce bone repair, amputation may not be necessary. S...Researchers discover why mutant gene causes colon cancer
... retinoic acid. If this process is impaired, colon cancer can result. "For a long time, scientists beli...tified the APC gene, as well as an inherited colon cancer predisposition known as familial adenomatous polyposis (FAP) that occurs in people who have APC muta...Ventilation in bars, casinos doesn't control health risk for hospitality workers
...n. Five years later, he estimated that 5,000 lung cancer deaths per year in the U.S. were caused by passive smoking, in a seminal study. Innovators Combating Substance Abuse is a national program of The Robert Wood Johnson Foundation that recognizes and rewards those who have made substantial, innovative c...Hunting illusive signs of natural selection
... involved in susceptibility to aggressive prostate cancer and since there is a large difference in the prevalence of prostate cancer between the European- and African-American populations, TRPV6 may be the selected gene. TRPV6 and T...New research suggests link between maternal diet and childhood leukemia risk
...d who develops leukemia, the most common childhood cancer in the United States. "This is the first time rese...t in the protein group with a strong link to lower cancer risk. Glutathione is an antioxidant found in both meat and legumes, and it plays a role in the synth...A new protein is discovered to play a key role in cancer progression
...k between these two proteins in the development of cancer and suggest that restoring their activity may provide a possible cancer treatment. "Through our discovery of the biologic function of PML and its essential role in maintai...Final Alert: 16th EORTC NCI AACR Symposium
... offers: First-time public presentations on new cancer drug research and development from experts in Euro...Phase I study of first second-generation antisense cancer drug used in patients Trial shows which brain cancer patients benefit from temozolomide genetic p......resilient and aggressive cancers a virulent brain cancer known as glioblastoma. The new approach to trickin...mber 3, 2004, issue of the journal Science. Many cancer cells are particularly hardy because they have switched off the apoptotic machinery at one point or ...Rising childhood leukaemia incidence prompts conference
... to pin down the causes and emerging concerns that cancer treatments are leaving survivors vulnerable to future serious health risks that has prompted the charity to summon top international experts from Europe, America, Asia and Australia to discuss the problem and, it is hoped, set an agenda for future re...Optimizing protein's 'death domain' halts leukemia in laboratory study
...covery could aid in the discovery of new drugs for cancer and other diseases. The researchers plucked a cri...ally reinforced it, so we were able to get it into cancer cells and kill them." Loren D. Walensky, MD, PhD, of Dana-Farber and Children's Hospital Boston is t......ysiologically, "an issue that's also of concern to cancer research," he adds. In addition, he and his colleagues will be trying to understand how BMP4 and other morphogenetic molecular activities are regulated to adapt to environmental changes. Chuong's laboratory has taken a global approach to the study of...Small, Smac-like molecule encourages death of cancer cells
...cells, a finding that could lead to more effective cancer therapies with fewer side effects. In the Sept. 3 ... by Smac, will keep the cell alive and growing. In cancer cells, IAPs tend to be overexpressed, and the signals that tell mitochondria to release Smac are oft...Molecular staples shape a cancer killer
... protein called BID that could induce apoptosis in cancer cells. Their objective was to create a short pepti...ring of amino acids -- could insinuate itself into cancer cells to trigger their suicide. "Our goal was to modify the natural peptide sequence only enough to...Diabodies act as guided missiles targeted to mammary tumor growth
...sting radiation thwarts the growth of human breast cancer in laboratory animals, according to research published in the September 1 issue of the journal Cancer Research. The research shows that a diabody, an antibody surrogate just one third the size of native antibodies, can be used effectively as a targe...Select research highlights from current AACR journals
...atment with melphalan, an alkylating agent used in cancer therapy for ovarian cancer and certain bone marrow tumors. In rat models for fibrosarcomas, Abdel-Wahab et al. documented that ...Chernobyl study: Risk of thyroid cancer rises with radiation dose
SEATTLE The risk of thyroid cancer rises with increasing radiation dose, according to the most thorough risk analysis for thyroid cancer to date among people who grew up in the shadow of the 1986 Chernobyl power-plant disaster. The incid...Cervical cancer is the second most common cancer among women worldwide. Research has shown that progression of the pre-malignant stages to invasive c...