New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...2 could suppress activation of ras and reverse the cancerous growth of human leukemia cells in test tubes. "These results suggest that inhibition of GRB-2 interactions may provide a useful therapeutic target for treatment of [chronic myelogenous leukemia] as well as other tyrosine kinase-associated human cance...Tumor Suppressor Gene Located In Liver Cancer Cells
...zed that losing it might well predispose a cell to cancerous growth. Their past studies showing that the protein was abundantly present in normal liver cells, but nearly absent in cancer cells, strengthened their suspicion. In research published earlier this year in the journal Oncogene, Jirtle's team found t...Rosemary May Have Anti-Cancer Properties
...ion phase, or the transformationof normal cells to cancerous ones. The study, directed by John Milner, professorand head of the Department of Nutrition, is reported in the May issue ofthe Journal of Nutrition. The results have "profound dietary implications," according toMilner. "We have found a spice that o...Researchers Find Possible New Route to Making Cancer Cells Vulnerable
...lling chemotherapydrugs that would normally kill a cancerous tumor and allowing runaway cellgrowth to continue. Physicians and researchers have been searching for waysto clog the MDR pump for many years. But many promising MDR blockers haveturned out to be toxic in the doses needed for them to be effective. ...Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein
...esulting in the transformation of normal cellsinto cancerous ones. The work by the Hughes-Rockefeller team confirms earliermodels that showed the change in the protein's shape that enables it totransform cells, but shows, unexpectedly, that it is the SH3 domain that is theprime controller of the enzyme's activ...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
... a vaccine to completely eliminate theformation of cancerous tumors in animals or humans. Lead author of the report is Yuman Fong, M.D., one of theworld's leading liver cancer surgeons, at Memorial Sloan-Kettering Cancer Center in New York City. Other authors includeHoward Federoff, M.D./Ph.D., chief of t...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...a vaccine to completely eliminate the formation of cancerous tumors in animals or humans. Lead author of the report is Yuman Fong, M.D. , one of the world's leading liver cancer surgeons, at Memorial Sloan-Kettering Cancer Center. Other authors include Howard Federoff, M.D./Ph.D., chief of the University of R...Second Look Acquits Gene Of Role In Breast Cancer
...and Maxwell Lee,Ph.D.,studied TSG101 in normal and cancerous human breast cells, and in other cells. They found...licing'process that something's going wrong in the cancerous cells." In many cases, the cancerous cells cut too much out of the RNA, or pastedthe remainingR...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...play a major role in the transition from normal to cancerous growth. "The telomerase enzyme i...bserved levels of telomerase activity in normal or cancerous cells. Finding the critical catalytic subunit that actually transcribestelomerase's RNA temp...Trojan Horse Virus Controls Hiv Infection
...o the bodyviruses or toxins to destroy infected or cancerous cells, ortherapeutic genes to protect uninfected cells against an invading virus. Moreover, such vectors could be used as novel vaccines todeliver antigenic genes to antigen-presenting cells, such as dendritic cells,for mounting immune protection aga...Low Oxygen, Key To Fetal Development, Also Offers Cancer Clues
... the uterus bears aremarkable resemblance to how a cancerous tumor invades healthytissue, says Ludlow, but the reaction of cancer cells to hypoxiais reversed. Ludlow's laboratory has shown that when facing low-oxygen conditions, ovarian cancer cells stop proliferating butstill invade healthy tissue. "In b...Study Shows Hereditary Legacy Of Radiation Exposure
...elp but wonder if these changeswill turn out to be cancerous or impair reproduction." Wiley's work was funded by the NationalInstitutes of Health ....Green Tea Ingredient Can Kill Cancer Cells
... ingredient, called epigallocatechin-3-gallate, on cancerous human and mouse cells of the skin, lymph system, and prostate, and on normal human skin cells. In the test tube, it led to apoptosis, or programmed cell death, in the cancer cells, but left the healthy cells unharmed. Findings appear in the December...Mystery Of Vital Cell Protein Solved After 30 Years
... drug, one that interacts only with the tubulin of cancerous cells,could be synthesized. "An awful lot of people have wanted to know what tubulin looks like atthe atomic level," says Nogales. "The knowledge gained from this model shouldbe of invaluable help in understanding the microtubule system in t...Molecular Defect Could Be Mysterious Cause Of Blood Disorder
...t disease. "Polycythemia vera mimics other cancerous and non-cancerous blooddiseases," says Jerry L. Spivak, M.D., professor of medicine and oncology atHopkins and senior author of the research report. "We now have a diagnostictool that we hope will identify patients earlier, perhaps increasing theirl...Renowned Breast Cancer Experts Present Latest Findings At UCSF Cancer Center Symposium
...pidemiology and Geneticsaims to determine just how cancerous "cancer genes" really are. In hispresentation, Struewing will describe creative scientific approaches he is usingto find more accurate answers to questions of genetic cancer risk. Struewing and his NCI colleagues published findings in the Ma......surgically remove most precancerous polyps and any cancerous lesionsthat may develop in the gastrointestinal tract. Approximately 25,000 - 50,000individuals in the United States suffer from FAP, with a similar incidence ofthe disease in Europe and Japan. Precancerous colon polyps, histologically andgenetically...New Biomaterial Has 'Star' Power
... a gel so that some of the arms recognize specific cancerous cells, while other arms in the same gel carry an anti-cancer drug," he says. "These gels also could be used as a surface coating, such as on an artificial organ, to provide additional binding sites for cells or antibodies." Keys used gamma radia...Combination Therapy For Brain Tumors Holds Promise For Longer Survival After Surgery
...py after removal of thetumor to mop up microscopic cancerous cells that could lead to regrowth.Brain tumors, however, are extremely resistant to radiation treatment.Researchers at the University of Pennsylvania Medical Center have now founda way to make brain cancer cells more receptive to radiation treatment ......eered in Van Dyke?s laboratory to develop a typeof cancerous brain tumor that occurs rarely in people. Some of these"transgenic" mice were selectively bred not to have E2F1. "We found that cell death was diminished by 80 percent in the tumors of animalswithout E2F1," Van Dyke says. But the researcher and her ...