Chemical derived from vitamin-E shows early promise as cancer drug
...c analog (alpha-TEA), to prevent colon and breast cancers in preclinical animal models. Mice in the study were treated with alpha-TEA for 21 days after an injection of mouse-derived mammary cancer cells that normally would have formed a tumor mass and spread (metastasized) to the animals' lungs. Regardle...New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
...o believe it is likely to prove effective in other cancers such as multiple myeloma. Dr. Ghavamzadeh, professor of medicine at Tehran University, today (Wednesday 29 September) reported at the EORTC-NCI-AACR[1] Symposium on Molecular Targets and Cancer Therapeutics in Geneva that two courses of the drug achi...Phase II trials of second-generation antisense cancer drug planned following successful early study
...et clusterin was inhibited by OGX-011 in patients' cancers in a dose dependent way. "This means that the dru...1. Post surgery analysis of the patients' prostate cancers showed that the higher the dose of OGX-011 given, the lower clusterin levels were within the cancer ...Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...omise in animal studies, successfully treating new cancers that have spread into the lungs of mice. The mouse... genetically engineered listeria vaccine to target cancers such as pancreatic and ovarian cancer, and possibly leukemia and various solid tumors. The listeria ...Trial shows which brain cancer patients benefit from temozolomide
...tomas, which make up around 12 to 15% of all brain cancers with 2-3 new cases diagnosed per 100,000 population annually in Europe and North America[2]. The drug was approved in 1999 for use in patients who have relapsed after initial treatment. "Our results should encourage and fuel further multidisciplinar...Genetic differences might help distinguish thyroid cancers
...r or five genes. Distinguishing between the two cancers is important because the malignancies behave diffe...m. Thyroid cancer represents one percent of all cancers in the United States and is the most common cancer of the endocrine hormone system. Over the last fe...Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
...apoptosis--the cell's self-destruct program. Most cancers activate telomerase to maintain telomeres in order...ells survive and multiply. However, a minority of cancers use a poorly understood mechanism called "alternative lengthening of telomeres" (ALT) to maintain te...Cannabis may help combat cancer-causing herpes viruses
...r virus, which predisposes infected individuals to cancers such as Burkitt's lymphoma and Hodgkin's disease. Once a person is infected, these viruses can remain dormant for long periods within white blood cells before they burst out and begin replicating. This reactivation of the virus boosts the number of c...$7.5 Million grant to Yale researchers for role of viruses in cancer
...Collaborating with DiMaio, she has found that some cancers may be due to inaccurate DNA synthesis by error-prone DNA polymerases. "Working collaboratively on these related projects has enabled us to make much more rapid progress in understanding the molecular basis of cancer," said DiMaio. ...Experimental drug shown to block mutant protein causing blood disease
...ring drug Gleevec, one of the first drugs to treat cancers by shutting down abnormal kinase signal switches. ...ive in treating MPD, as well as other diseases and cancers where mutant FGFR1 is the culprit. These include human skeletal disorders such as Pfeiffer syndrome,...Key stimulator of colorectal cancer identified
...es a molecule that promotes one of the most deadly cancers in humans and reveals the molecular mechanisms underlying the protective effects of nonsteroidal anti-inflammatory drugs (NSAIDS) against the disease. The research, published in the September issue of Cancer Cell, identifies potential targets for fut...Targeted therapy knocks out pediatric brain cancer in mice
...ember issue of Cancer Cell. "Therapy for pediatric cancers of the central nervous system has not improved significantly in the last three decades," explains study author Dr. Tom Curran from St. Jude Children's Research Hospital in Memphis, Tennessee. "This is partly due to the absence of adequate model syste...USC study links historical increases in life span to lower childhood exposure to infection
...decades later, leads to heart attacks, strokes and cancers the classic killers of old age. "We've put pieces together that are in front of everybody's nose and made a coherent hypothesis," said Caleb Finch, the study's lead author and holder of the ARCO-William F. Kieschnick Chair in the Neurobiology of ...Researchers identify distinctive signature for metastatic prostate cancer
...hat could help clinicians predict whether prostate cancers are likely to spread or remain relatively harmless...evated activity distinguishes dangerous metastatic cancers those that are likely to spread from those that remain benign and localized to the prostate. Pros......tory from one of the most resilient and aggressive cancers a virulent brain cancer known as glioblastoma. Th...eath machinery could be applied to a wide range of cancers where this pathway, known as apoptosis, has been inactivated. The researchers -- led by Xiaodong Wa...Rising childhood leukaemia incidence prompts conference
... die from it. It accounts for about a third of all cancers in children. The number of new cases diagnosed annually has been rising for at least 40 years, particularly in children under the age of five, he said. Importantly, by analysing the reliable mortality trends available between 1911 and the 1950s, toge...Molecular staples shape a cancer killer
...f apoptosis. These are necessary because different cancers may have thwarted the apoptotic machinery in different ways, he said. "The goal would be to use the natural sequences of these pro-apoptotic peptides to try to specifically activate the cell death program in a resistant cell," said Walensky. "For ex...Chernobyl study: Risk of thyroid cancer rises with radiation dose
...red; the majority were under 16 when their thyroid cancers were diagnosed. They then identified 52 healthy control subjects from the general population for comparison purposes. The controls and cancer cases were matched by age and place of residence at the time of the accident. The researchers then set about...Zoledronic acid zings cervical cancer
...e mice. The researchers first showed that cervical cancers in this mouse model had several characteristics similar to human cervical cancer. They further found that an important player in cervical cancer progression was an enzyme called matrix metalloprotease-9, which stimulated angiogenesis. The researcher...Study reveals first genetic step necessary for prostate cancer growth
...ely resembles how genes are inactivated or lost in cancers that occur sporadically in humans. The scientists ...may never cause harm and those who have aggressive cancers that require treatment. Researchers are eager to develop tests that can stratify early stage prostat...