JCI table of contents: 1 September, 2004
...e mice. The researchers first showed that cervical cancers in this mouse model had several characteristics si...2087.pdf Stopping Skin Cancer -- Stat3 Human cancers generally develop through several steps -- initiation, promotion, and progression -- which require t...Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
...lls," he said. "We also do not know against which cancers SUL's microtubule-targeting actions are most effective." Future studies in Singletary's lab will address those issues....How an insidious mutation fools DNA replication
... DNA damage -- a process long believed to underlie cancers and aging -- can create permanent genetic damage. The Duke University Medical Center researchers' findings were published online Aug. 22, 2004, by the journal Nature. The scientists were led by Associate Professor of Biochemistry Lorena Beese, Ph.D.,...University of Pittsburgh receives $10 million grant for head and neck cancer
...evelopment of many cancers, p53 is damaged in most cancers and this damage is correlated with worse clinical ... for 4 percent to 5 percent of all newly diagnosed cancers in the United States. More than two-thirds of head and neck cancer patients have a locally advanced ...Tiny molecules have big potential as cancer drugs, Stanford researcher believes
...e shown that more of the cathepsins are present in cancers and that they appear to be secreted by cancer cell...ince cathepsins are associated with many different cancers and are involved in processes such as blood vessel formation and tumor growth critical to all tumo...Trojan Horses, xenon imaging and remote controlled genes
...t we hope will identify biomarkers associated with cancers of the lungs, brain and pancreas," Dmochowski said. "Over time, we'll be able to use MRI to detect aberrant proteins that cause cancer in humans before the actual formation of a tumor." "Trojan Horse" Proteins Dmochowski and his colleagues a...Study narrows search for genes placing men at increased risk for prostate cancer
...target our surveillance to them and identify their cancers much earlier. Early-stage treatment is far more b...cer," she says. In addition, she noted, prostate cancers in men who possess susceptibility genes tend to be more aggressive--and more often fatal--than prost...JCI table of contents, 16 August, 2004
... has built in anti-tumor mechanisms. In order for cancers to form, one of the molecular steps that must occu...ersity of Washington, now investigate how prostate cancers evade this anti-tumor defense strategy. The researchers found that MIC-expressing prostate cancer ce...MICs shed light on prostate cancer
... has built in anti-tumor mechanisms. In order for cancers to form, one of the molecular steps that must occu...ersity of Washington, now investigate how prostate cancers evade this anti-tumor defense strategy. The researchers found that MIC-expressing prostate cancer ce...Ovarian cancer sheds tumor suppression with loss of estrogen receptor
...This disappearing act may help explain why ovarian cancers are often typically resistant to anti-estrogen dru... leader in molecular and cellular endocrinology of cancers at Inserm U540, Montpellier, France. "We hypothesized that this may be due to the selective decrease...Leukemia stem cells identified by Stanford researchers
... protein was particularly abundant in people whose cancers were resistant to the chemotherapy drug Gleevec. Beta-catenin is part of a pathway kicked off by a protein called Wnt (pronounced "wint"), which has only recently been found to play a role in helping stem cells continue dividing. Wnt is normally only...Small animal imaging gives cancer clues
...s researchers touse mice more effectively to study cancers comparable to humandisease. The system can disting...for small treatment effects. Most invasive breast cancers are thought to develop from DCIS, andstandard care is to remove the entire area involved, Borowsky s...New prostate cancer gene identified
...nt of its involvement in prostate cancer and other cancers as well." "These findings represent a significant advancement in prostate cancer research, as the number of current treatment options for advanced prostate cancer remains limited," said Dr. John Carpten, Senior Investigator at TGen, Director of its G...UCSD researchers are first to demonstrate molecular link between inflammation and cancer
...ferent cancers, the researchers chose one of these cancers colitis associated cancer (CAC) as their model for study. CAC occurs in people suffering from chronic colitis, which puts them at very high risk for cancer. "We've shown how tumors arise from chronic infection and inflammation that act together ...Transcriptional gene silencing in nucleus shown by UCSD/VA medical researchers
... in virus infections such as HIV, as well as human cancers and certain genetic disorders." In continuing studies, the Looney lab and others in the country will investigate this new method's persistence within the human-cell nucleus, its successful targeting of human promoters, and whether it is feasible ...New discovery may help transplants survive
...at access to lymphatics and lymph nodes is the way cancers spread through the body," he says. "The findings of Dr. Dana and his colleagues provide new insights into transplant immunology and biology which go well beyond the eye, and offer new therapeutic approaches in organ transplantation and cancer treatme...Clusters of alterations on PIK3CA gene found in brain cancers
...in as much as 30 percent of colorectal and gastric cancers and glioblastomas and they are also present, to a ...ion of PIK3CA as an oncogene associated with brain cancers opens the door to screening processes that can identify patients for treatment strategies, as well a...Blood pressure hormone may inhibit growth of lung cancer
...said. The cells for their research came from lung cancers in a 60-year-old female, a 58-year-old male and a 65-year-old male. None of the other angiotensin hormones tested slowed the growth of these lung cancer cells. Tallant and Gallagher said their studies may point the way to a more successful treatment......isk. In black women, a higher proportion of breast cancers are diagnosed with unfavorable characteristics." Dr. Chelbowski points out that genetic and biochemical factors may be the source for those high-grade, receptornegative cancers. He points out that, "Black women might have a genetic profile that puts...