Location of potential familial lung cancer gene discovered
...combined with the large amount of spontaneous lung cancers that arise from smoking, makes finding potential histories of familial lung cancer or collecting genetic samples extremely difficult and time consuming. "This study is just further proof of the importance of cooperative efforts and large-scale scien...New view of leukemia cells identifies best treatment options, Stanford researchers say
...the pathways most commonly disrupted in aggressive cancers could help researchers predict which patients won't respond to standard chemotherapy. Doctors could immediately propose that the person consider less common therapies. "This is the first time we've been able to look at cancer signaling messages ...Researchers uncover surprising degree of large-scale variation in the human genome
...g DNA segments) associated with a variety of human cancers in individual patients (see http://www.cshl.edu/public/releases/revealing.html ). However, in the course of that work, the researchers were greatly surprised to have detected several large-scale, previously unidentified differences in human D...Study yields insights into precancerous condition
...eatment of the condition, which has been linked to cancers of the gastrointestinal tract, lung, breast, uteru...ing tested in clinical trials for the treatment of cancers and tuberous sclerosis, may be useful for the treatment of polyps arising in PJS patients, and possi...Drug prevents chemotherapy-induced hearing loss, study finds
... treat cervical carcinoma, lung cancer, neurologic cancers and a wide variety of other malignancies. But it injures hair cells of the cochlea, the spiral, inner-ear structure containing thousands of tiny hair cells that vibrate in response to sound waves. "These hair cells are often destroyed," Dickey said. ...Gene expression patterns may help predict risk and progression of prostate cancer
...sease. "Since only a fraction of prostate cancers are metastatic, identifying variables that predict the behavior of a prostate cancer tumor based on gene expression patterns should prove important in clinical management of the disease," said Dr. Luo. "The results of this study are a first step in t...Scientists identify molecular link driving spread of skin cancer
... million cases of basal cell or squamous cell skin cancers occur annually; melanoma and other non-epithelial skin cancers will cause an estimated 10,250 deaths in 2004....Findings suggest need for new view of p53 cancer protein's interaction with DNA
...3. Scientists estimate that at least half of human cancers involve mutant p53. In the course of performing its regular duties, the normal p53 protein binds to DNA, and a number of cancer-linked p53 mutations affect the DNA-binding region of the p53 protein. But precisely how does the p53 protein bind to DNA?...Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
...n, naturally have high levels of AGT. This enables cancers that arise in the brain to resist chemotherapy. Ca...g" or expressing excess amounts of AGT. When these cancers do this, they are rendered resistant to alkylating agents. Wanting to understand how AGT repair wor...Anti-cancer agent built from anti-inflammatory drug
...hat it may sensitize leukemia, and breast and lung cancers to conventional chemotherapy." The new agent is based on the drug celecoxib, a nonsteroidal anti-inflammatory drug, or NSAID. Like many NSAIDs, celecoxib also reduces the risk of colorectal cancer when taken regularly. Scientists knew from the start ...Milk consumption and calcium intake associated with lower colorectal cancer risk
... decreased risk of colorectal cancer, particularly cancers of the distal colon and rectum. The risk decreased with increasing milk consumption; compared with people who consumed less than 70 grams/day (about 2.5 ounces) of milk, people who consumed 175-249 g/day (6.2-8.9 oz.) had a 12% reduction in risk of c...How DNA repair machinery is a 'Two-Way Street'
...hich could have implications for understanding how cancers become resistant to chemotherapy. "This system does more than just repair DNA biosynthetic errors," he said. "Many cancer chemotherapeutic drugs work by damaging DNA, which selectively kills cancer cells because they are proliferating more than resti...USC researcher named General Motors Cancer Research Scholar
...sion of sporadic breast cancers. (Sporadic breast cancers are those that are not directly associated with a specific genetic mutation.) Rice's work at the Keck School is concentrated on so-called epigenetic gene regulation the heritable on and off switches of genes that are associated with chemical modific...North Shore-LIJ research collaboration with Correlogic Systems to advance ovarian cancer blood test
...s high as 90 percent. Unfortunately, most of these cancers are caught only after the disease has progressed to the later stages, when the survival rate is only about 25 percent." This collaboration was brought about through the leadership of U.S. Rep. Steve Israel, of Huntington, co-chair of the House Cancer...JCI table of contents, 15 June 2004
... is already known that about one half of all liver cancers show a decrease or loss of expression of the PTEN gene. Surprisingly, however, Akira Suzuki and collaborators, from Akita University, now report a new role for this tumor suppressor gene. The researchers found that a lack of PTEN in the liver leads ...Whole body imaging allows better understanding of the immune system
...utions to understanding the cause of certain blood cancers and immune disorders, findings that have led to the development of improved therapies for patients, including a widely used molecularly targeted therapy for chronic myeloid leukemia (CML). But now, combining his experience as a cancer biolog...Scientists identify cells that lead to retinoblastoma
... why retinoblastoma occurs in children while other cancers such as colon and lung cancer occur in adults, developing after decades. Featured as the cover story in the June issue of Cancer Cell, this discovery paves the way for developing new treatments for retinoblastoma that target these first cancerous cel...APP reports Abraxane(TM) is active in breast cancer patients who failed taxol or taxotere
...,110 deaths estimated in 2004. One of every three cancers diagnosed in the United States is breast cancer; excluding skin cancer, breast cancer is the most common cancer among women....New laboratory model can be used to test new treatments for pediatric eye cancer
... to teach us more about the genetic basis of other cancers as well." Other authors of the paper are Jiakun Zhang, M.D., Ph.D., and Brett Schweers, Ph.D., both of St. Jude. ...Gene therapy tested to protect bone marrow during chemotherapy
...d to improve treatments for patients with specific cancers and with inherited stem cell diseases. ...