Tag: "cancers" at biology news

Avastin-Tarceva combo provides 'one-two' punch against lung cancer

... people each year, more than the next four leading cancers (colorectal, breast, prostate and pancreas) combined. About 85 percent of all lung cancers are non-small cell cancers, and nearly half of these patients are diagnosed with advanced disease an...

Gene expression ratio identifies risk of recurrence in breast cancer patients receiving tamoxifen

... and its receptor protein, is used to treat breast cancers that express the estrogen receptor. However, only two thirds of these patients have a prolonged response to the drug. "Until now, there has been no way to predict which estrogen-receptor-positive patients will not respond to tamoxifen treatment," say...

Why lung cancer in women is different from men

... cancer takes more women's lives than reproductive cancers and breast cancer combined," said Albain, WALC vice president and professor, division of hematology/oncology, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, Ill. "We must devote more resources to battling thi...

Molecular marker predicts success of breast cancer treatment

...a examined the gene expression levels in 60 breast cancers from patients who were treated with tamoxifen after their surgery. Measuring gene expression is a way to examine whether or not a gene is functioning. They discovered that the ratio of the expression levels of two genes, HOXB13 and IL17BR, accurately...

Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor

... Because nearly three-quarters of all breast cancers are stimulated by estrogen acting at functional es... tamoxifen. However, only about half of ER+ breast cancers successfully respond to treatment with tamoxifen, while the other half are resistant. When tamoxifen...

Drug that cuts off tumor's blood supply extends lives of colorectal cancer patients

... year alone, killing about 56,730. Overall, colon cancers are the third most common cancers in men and women, and the second leading cause of cancer death in the United States....

Umbilical cord blood transplants, bone marrow transplants save lives

...sity are curing or slowing the progression of many cancers originating in the bone marrow (i.e., leukemia, myeloma) or lymphatic system (lymphoma). More than 106,000 people in the U.S. each year are diagnosed with these life-threatening diseases. "Even if other treatments have produced no results, a bone...

Researchers identify new target of protein involved in cancerous cell growth

...s of research in the development of treatments for cancers and parasitic infections. "Scientists have known for many years that Ras proteins work as molecular 'on/off' switches that can change the way cells grow, and interact with other cells. Mutated forms of Ras that are locked in the 'on' position are inv...

Shortened chromosomes linked to early stages of cancer development

...re lengths. More than one million human epithelial cancers are diagnosed every year, Meeker says, and these cancers cause a half-million deaths each year. Previous studies by the research team and others at Johns Hop...

Gene expression profiling may predict head, neck cancer recurrence

...d and neck tumors account for more than 40,000 new cancers annually in the United States. The most common of these is squamous cell carcinoma. Prognosis is based largely on location and size of the tumor, and if the cancer has spread, or metastasized, to lymph nodes and distant sites in the body. The study i...

The UV advantage

...se, stroke, and breast, colon , prostate and other cancers Alleviation of skin disorders Decreased risk of autoimmune disorders including multiple sclerosis, Type I diabetes mellitus, and rheumatoid arthritis Enhanced mental health and lessening symptoms of seasonal affective disorder, premenstrual syndro...

A new way to kill cancer: SLU research shows viruses can destroy lung, colon tumors

...e. "These viruses have the potential to treat many cancers that are resistant to currently available therapeutics. It also may be possible to use these viruses in combination with other therapies to create novel treatment regimens." Dr. Wold and his colleagues Karoly Toth, Konstantin Doronin, Ann E. Tollefso...

Second generation targeted antibodies - It's all in the binding

...tent anti-tumor activity in animal models of human cancers that overexpress EGFR. The LICR Melbourne Branch has a longstanding research program in EGFR structure and biology, and in a recent pivotal discovery participated in defining the 3D-structures of the extracellular domains of the EGFR and a related pr...

Soy processing influences estrogen-dependent breast cancer growth in mice

...T), but this is the age group in which most breast cancers occur. Seventy-five percent of breast cancer cas...stmenopausal women with estrogen-responsive breast cancers who are looking for alternatives to HRT," he said. In the study, mice were fed equal concentration...

National Cancer Gene Therapy Foundation gives $4.0 million in research grants

...t the growth of this independent blood supply that cancers need. A type of stem cell called an endothelial cell precursor (ECP) that plays a role in the formation of new blood vessels has recently been identified. Dr. Lane and his lab have identified a genetic element expressed in ECPs and created a virus ...

Transplant rejection averted by simple light exposure in Stanford animal study

...ansplants are commonly used to treat patients with cancers of the blood system, such as leukemia, lymphoma or myeloma. Patients first receive radiation treatment to wipe out their defective immune systems, which then are replaced by healthy donor cells. Sometimes, however, the process fails as GVHD sets in. ...

Chromosome losses mean poor survival in childhood leukemia

...one into complete remission. All the children had cancers showing the Philadelphia chromosome, an alteration in the genes that indicates a poorer response to treatment. Sixty-one percent of the patients (153), showed secondary chromosome abnormalities; that is, abnormalities present in addition to the Phila...

Small gene changes in some leukemia patients may explain varying responses to chemotherapy

...000 new cases are diagnosed each year. Unlike most cancers that occur because cells divide uncontrollably, CLL is caused primarily by defective apoptosis. Cells live an unnaturally long time and fail to die when they should. Patients diagnosed with CLL can live for months or years and can have varying respon...

Other highlights in the May 5 JNCI

...sociated with an increased risk of developing skin cancers and non-Hodgkin's lymphoma, according to a new stu...xpected number. There were more cases of all these cancers than expected, particularly among people who had received 15 or more glucocorticoid prescriptions, i...

Molecular mechanism found that may improve ability of stem cells to fight disease

... treatment for patients with advanced or recurrent cancers of the blood, such as leukemia and lymphoma. The study was funded in part by grants from the National Institutes of Health. Co-first-authors include Youzhong Yuan, M.D., Ph.D., and Hongmei Shen, Ph.D., at the University of Pittsburgh Cancer Institut...

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