Tag: "cardiomyopathy" at biology news
Transgenic Mice Created By Researchers May Shed Light On Human Heart Disease
...ganized. Although people with hypertrophic cardiomyopathy
often have largerhearts than normal people, the he...gen to search for newways of treating hypertrophic cardiomyopathy
in humans. "We are lookingfor ways to improve the motor activity in the heart muscles," she said."T...
Gene-Altered Mice Boost Studies of Cardiomyopathy: Enables Research Into Causes And Treatment Of Heart Failure
...ty of Chicago and director of the study. Dilated cardiomyopathy
is an important cause of congestive heart failur... of 65 and a leading cause of death. In dilated cardiomyopathy
the heart muscle expands and weakens -- ballooning out like an over-stretched rubber band -- until i...
Virus Linked To Causing Enlarged Hearts In Children With Certain Genetic Makeup
...tion can lead to idiopathic(cause unknown) dilated cardiomyopathy
-- a condition in which the heart becomesenlarged ...eart diseasetriggered by infection, which precedes cardiomyopathy
-- researchers foundevidence that the immune system was responding in an unusually aggressive way to...
Heart Disease Symptoms Worsen When Body Tries To Adapt
...ns and obstructs blood flow. Hypertropic cardiomyopathy
is associated with changes in the proteinsprincipa...therapies." More than half of hypertrophic cardiomyopathy
cases are hereditary. Thedisease affects about one in 1,000 people, causing shortness of breath,diz...
Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant
...or fatal disorders -such as metabolic myopathy and cardiomyopathy
(heart failure). "We'vedemonstrated proof of concept that the methodology can work for both skeletaland cardiac muscle," says principal author Hansell Stedman, MD, assistantprofessor of surgery at Penn's Institute for Human Gene Therapy, "so the ne...
Awareness, quick action key to battling canine bacterial disease
...s, bloody diarrhea. Profound hypotension and toxic cardiomyopathy
may develop. At this point, antibiotics and even with aggressive shock therapy are generally not sufficient to save these dogs....
Tailoring mitochondria to the cell's needs
...ation of cardiac mitochondria but develop dilated cardiomyopathy
and die at an early age. How increased mitochondrial function might alter heart development is still unknown....
Hopkins wins $14 million NIH grant for genetic cardiopulmonary disease research
...y will also examine two heart conditions: ischemic cardiomyopathy
(heart failure after heart attack) and transplanted heart. The researchers hope to have useful results for at least two or three of the diseases in six months. "There may be genes common to many of these conditions, or we may wind up at the same fi...
Gout drug could offer hope for heart failure patients
...ne patients (seven men and two women) with dilated cardiomyopathy
a cause of severe heart failure in which the lowe.... The research team also took tissue samples from cardiomyopathy
patients undergoing heart transplant and used them to measure amounts of xanthine oxidase (XO) an ...
Genetic clues for finding and treating cardiovascular disease (CVD)
...e been identified as the specific cause of dilated cardiomyopathy
and another six susceptibility genes have been noted. CVD may also result form the interaction between genetics and their interaction with the environment, defined as smoking, obesity and the like. Program Highlights Physiological genomics is the...
Failure of critical protein connection at heart of cardiomyopathy
...lds heart muscle cells together, can cause dilated cardiomyopathy
(DCM), a condition in which the pumping chambers o...eaken, the child requires a wheelchair and dilated cardiomyopathy
occurs. A mutation in the dystrophin gene causes these diseases. However, in the case of dilated ca...
Study suggests mechanism for heart defect that kills young athletes
... athletes a heart condition known as hypertrophic cardiomyopathy
can develop from a single genetic mutation that d...oteins that interact in heart muscle. Hypertrophic cardiomyopathy
affects one person in 500, and genetic defects are thought to be responsible for at least half of al...
The MAP kinase pathway in coxsackievirus infections
...s of mice, infection of the heart provokes dilated cardiomyopathy
and can lead to heart failure. Earlier work showed that the MAP kinase signaling is induced by infection and suggested that this pathway might contribute to efficient viral replication. The authors have now identified signaling molecules essential fo...
JCI table of contents, January 15 2003
...e-jci.org/press/17605.pdf Idiopathic restrictive cardiomyopathy
is part of the clinical expression ofcardiac Troponin I mutations CONTACT: William J. McKenna St. George's Hospital, Medical School Department of Cardiological Sciences Cranmer Terrace Tooting London, SW17 0RE GREAT BRITAIN Phone 1: 4420-8725-5911 ...
Scripps scientists discover new approach for treating 'misfolding diseases'
...copy. An analogous disease called familial amyloid cardiomyopathy
(FAC) causes fibril formation in the heart, which leads to cardiac dysfunction. About one million African-Americans carry the gene that predisposes them to FAC. Another amyloid disease affecting the heart, Senile Systemic Amyloidosis (SSA), afflicts ...
Researchers pinpoint cause of inherited form of heart failure
...odes the protein phospholamban could cause dilated cardiomyopathy
in humans. The Seidmans collaborated with scientis...the contractile ability of the heart. Hypertrophic cardiomyopathy
causes thickening of the left ventricular wall, reducing its pumping ability. Dilated cardiomyopathy...
Scientists identify same gene in mice, humans leading to heart failure
...in 20 unrelated individuals with inherited dilated cardiomyopathy
(a condition where the ventricles of the heart enl...hose who carried the mutant gene developed dilated cardiomyopathy
and heart failure. MacLennan and U of T post-doctoral fellow Michio Asahi, one of the first authors ...
Chronic alcohol abuse damages regulating hormones
...abetes insipidus ; may explain how alcohol-related cardiomyopathy
develops; and may show that there is a subclinically impaired renal function in these patients which clearly underlines the concept of multi-organ involvement in alcoholism, that is, not only are the liver and brain affected, but basically all organs...
JCI table of contents, May 15, 2003
...ARTICLE: TITLE: Activation of Mst1 causes dilated cardiomyopathy
by stimulating apoptosis without compensatory vent...geted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy
through upregulation of calcineurin-NFAT signaling AUTHOR CONTACT: Jeffrey D. Molkentin Children's H...
Seeking the cause of a mysterious whale disease
.... "We want to try to determine what's causing the cardiomyopathy
because right now we only have a list of possibili...tigation into the cause of the increase. Dilated cardiomyopathy
involves enlargement of and subsequent weakening of part or all of the heart, and can leave whales m...