Protein Glitch May Be Early Problem In Inherited Alzheimer's
...this cascade, but we have a theory about where the cascade is headed." According to Sisodia, mutated forms of presenilin may influence the formation of plaques in the brain that are among the earliest signs of Alzheimer's disease. Hopkins researchers currently are looking at mice in which the gene for presen...Bottom-up Ecological Processes Better For Clear Waters, Study Finds
...n" control of the food web is known as the"trophic cascade hypothesis," named and popularized by StevenCarpen... Brett decided to take another look at the trophic cascade hypothesisusing a newer statistical technique called "meta-analysis." Moresensitive to smaller effec...Scientists Discover How Genes Work Together To Control Neural Development
...g cells what kind of cell to becomeby initiating a cascade of internal molecular reactions called the "signaltransduction pathway." "Cancer can result if errors occur inthe signal-transduction pathway, giving a cell the signal to divide insteadof the signal to become a neuron," Carthew explains. "These signa......sby. "Thecumulative death of neurons may trigger a cascade of events that ultimatelyleads to clinical symptoms such as trembling, paralysis and cognitiveloss--manifestations typically associated with Alzheimer's disease, Parkinson'sdisease and ALS." Kisby says the research leads to a broader questi......molecules floating in the air, setting in motion a cascade ofreactions that create a perception of odor in the brain. "I believe this experiment will prove to be a Rosetta stone forolfaction, in that we can now begin to match odorants to receptors and decodethis elusive sense," said Darcy Kelley, pro...Columbia Researchers Identify Gene For Inherited Baldness
...ssue of Science, suggests thatthe gene initiates a cascade of events that stimulate hair growth. Each stepalong this pathway may provide new clues for male pattern baldness and otherforms of hair loss, or alopecia. "The discovery of this new gene gives us endless possibilities that mayallow us to ...Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation
...enge for the years to come is to understand the cascade of events that starts with the binding of ubiquitylated substrate protein and ends with its translocation into the 20S proteolytic core....Duke Researchers Genetically Engineer Mice To Block Heart Enlargement
...eart is through the proteinGq, which initiates the cascade of events inside the cell that lead to anenlarged heart," said Walter J. Koch, an assistant professor of experimentalsurgery, who led the team. "Our hope is that by demonstrating it is possible toblock this initiation step, we will eventually be able......variety of different inhibitors it is shown that a cascade of two proteases is essential for brain plasticity. These proteases are tissue plasminogen activator and plasmin, both known to be present and important in the cardiovascular system, where they participate in wo...Drunken Fruit Flies Reveal Molecular Pathway Regulating Sensitivity To Alcohol
...e cyclic AMP (cAMP) pathway, a signal transduction cascade thatscientists at the Gallo Center have long known was affected by alcohol throughstudies in human cells. This discovery fit with a previous finding, namely thatamnesiac is believed to encode a molecule that stimulates cAMP production. The scientist...DFG To Set Up 14 New Collaborative Research Centres
...s are membrane proteins whichin the cell trigger a cascade of processes whose last link consists of so-called transcriptionfactors regulating the "reading" of genes. Thus these signal pathways control central functionssuch as cell growth and differentiation as well as the individual cell's behaviour within t...Discovery Of Plant-Like Metabolic Pathway In Common Parasites Supplies New Targets For Therapy
...pathway." The parasites that rely on this chemical cascade are members of the phylum Apicomplexa , which includes many important human and animal pathogens,such as: <AHREF="http://martin.parasitology.mcgill.ca/jimspage/biol/PLASMOD.HTM"> Plasmodium: causes malaria, the single most important tropi...Novel Liver Steroid Slows Brain Tumor Growth
...k. It blocks orinterferes with several steps in a cascade of events involved in blood vesselgrowth. Based on the Hopkins laboratory work, it is currently in Phase Iclinical trials at the University of Texas (San Antonio) and at GeorgetownCancer Center. In laboratory tests, squalamine proved to be as...Researchers Identify A Protein Critical For T Cell Development And Activation
... substances, the T cellantigen receptor, starts a cascade of biochemical events that lead to T cellactivation. This cascade involves the activation of proteins which then activateother proteins in succession until the T cell......in responds to injury -- in terms of the cellular cascade thatleads to cell death -- is poorly understood. Looking at a particular pattern ofcell death called apoptosis, or programmed cell death, researchers at theUniversity of Pennsylvania Medical Center have discovered that in a rat modelthis kind of del......ty of the "killer proteins" and their place in the cascade ofevents leading to cell death has been a mystery to scientists for decades. Thecurrent research may fill one more piece in the puzzle. Vivek Rangnekar, Ph.D., associate professor of microbiology andimmunology, UK College of Medicine, discov...Team Solves X-ray Structure Of Powerful Enzyme
...nds of cellular activity. "The enzymes regulate a cascade of events related to almost every aspect of cellfu...hefirst to discover the enzymes and the signalling cascade they initiate in cells.Following this tradition, scientists in Anderson's laboratory were the first ......ic and Bering Sea fisheries may haveinitiated this cascade of ecological effects, Estes said. Estes and his coworkers reported their findings in the October 16 issue of thescientific journal Science. The researchers have been studying the role of sea otters in the coastalecosystem of Alaska's Aleutian arch...UCSF Finding Offers Insight Into Way Genes Regulate Aging And Life Span
...ior of other cells. "It may be that the signaling cascade prompted by daf-2 in certain cells occursin a similar way in the insulin/IGF family of receptors in mammals in responseto caloric restriction," said Kenyon. If this is the case, she said, it may be that the hormone signaling pathway inC. elegans hint...Scientists Finger A Molecular Kingpin In Body's Response To Cigarettes
...pollutant dioxin -- as a vital link in thechemical cascade whereby cigarette smoke causes cancer. Thefinding comes thanks to a batch of genetically engineered micenormal in every way except for the deletion of the gene for thearomatic hydrocarbon, or AH, receptor; these mice had no damagefrom the same levels...