Research reveals how cells protect against stress
...phosphate groups to other proteins. The resulting cascade of events ultimately causes closure of microscopic pores on the plants' leaves in an effort to limit the loss of moisture. In the present research, Assmann's group found that one of the targets of this ABA-activated kinase is a specific protein that ...Dinosaur ancestor's vision possibly nocturnal
...trigger the critical first step in the biochemical cascade of vision in humans and other animals and obviousl...psin triggered the rest of the signal transduction cascade in the photoreceptor cell; in other words, it interacted with the "second messenger," the G protein ...Scientists unlock secret behind cause of chronic lung disease
..., these macrophages become overactive triggering a cascade of events that destroy the lung and lead to an often slow and distressing death. The Hck enzyme is normally locked in an inactive state. In the presence of foreign bodies or disease, the Hck enzyme unlocks and becomes active. The active molecule th...Identification of the first gene in posttraumatic stress disorder
...nce of the disorder. Exposure, in fact, triggers a cascade of biological events that ultimately lead to the occurrence of chronic PTSD. Individuals with prior vulnerability are at higher risk for developing PTSD upon exposure to a trauma. Previous studies found correlates of abnormal biological reactivity o...Another job discovered for a master metabolic off-switch
...alled cyclic AMP (cAMP). This molecule launches a cascade of metabolic signals into the cell when it is produced by activation of receptors such as the "G-protein-coupled receptors" (GPCRs) studied by Lefkowitz's laboratory. The role of beta-arrestin is to desensitize GPCRs by regulating cAMP levels, to pre...Increasing nitrogen in Earth's soils may signal global changes, say U. of Colorado researchers
...gen does not go where it is supposed to, causing a cascade of environmental problems that are worsening at an alarming rate." Although rivers like the Mississippi have many times the amount of nitrogen than they contained 30 years ago, there are "tractable solutions" to the problem, he said. "Agricultural ...Algorithm predicts interactions between proteins whose structures are unsolved
...teracts with that small molecule or functions in a cascade of cellular processes." The paper describes how MULTIPROSPECTOR was able to correctly predict protein-protein interactions between many thousands of proteins in brewer's yeast, a model organism in structural genomics. Skolnick and his colleagues t...West Nile Virus capsid protein causes encephalitic inflammation by triggering cell suicide
...teins such as caspase-9 and caspase-3 that start a cascade of reactions to subsequently cause the cell to digest itself. Since the protein enters the nucleus of the cell, it is possible that WNV-Cp changes the host cell's transcriptional machinery, resulting in an over production of certain proteins related...Is there a common genetic link for depression and cardiovascular disease?
...ents for the signal transduction, as they induce a cascade of cell reactions after the incoming signal. Thus alterations in the function of these G-proteins could have tremendous effects upon rapidity and quality of the nervous signal transmission. And recently a mutation in one subtype of these G-protein ge...TSRI professor named industry pioneer in one of the top ten technologies that will change future
...idual gene transcript--carbohydrates are made by a cascade of chemical reactions inside our bodies. Many of these reactions are extremely hard to replicate in the lab. "The complex, branched structures of carbohydrates have prevented the development of efficient and routine methods that are key to unraveling...MIT sugars research affecting bypass patients, drug industry
...or's basic research on complex sugars has led to a cascade of potential medical applications that could, for example, significantly improve outcomes for patients undergoing major operations such as heart bypass surgery and impact a multi-billion dollar drug industry. In the online edition of the Proceeding......ctivates a mitogen-activated protein kinase (MAPK) cascade of sequential protein phosphorylation events insid...nizes VAB-1 inhibition of the MAPK phosphorylation cascade and thereby promotes oocyte maturation. "In the case of sex, two wrongs can sometimes make a right"...Newly discovered cellular process helps cells respond to DNA damage
... a process called phosphorylation. This sets off a cascade of biochemical reactions that amplifies the initial ATM response. Among the proteins phosphorylated by ATM are Brca1 and p53. It was already known that these proteins play important roles in preventing cancer, and that mutated forms of Brca1 and p53...Prion disease may be caused by buildup of cellular trash, say Stanford researchers
...machinery - may represent a downstream step in the cascade of events that leaves the brain looking somewhat like a kitchen sponge. "No one really understands how or why spongy degeneration develops," said Gregory Barsh, MD, PhD, professor of pediatrics and of genetics in the Stanford School of Medicine, in w...Stuart research funds generating dividends for veterinary medicine
...ulate inflammation. These cytokines also turn on a cascade of enzymes in the nucleus of cells that induce apoptosis. If we can figure out a way to stop apoptosis, we can reduce the morbidity from colic, said White. This opens up a whole new area to study in horses with colic. The work was reported at the Ame...Neurofibromin: It's so degrading
..." a specialized intracellular protein-degradation cascade -- and the subsequent activation of Ras. However, the researchers also found that shortly after neurofibromin is degraded, its levels re-elevate to attenuate Ras activity and prevent excessive cell proliferation. Since Nf1-deficient mice die during ...Researchers develop 'natural bandages' that mimic body's healing process
...cut, your body activates its clotting mechanism a cascade of reactions where fibrinogen is broken down and converted to fibrin. "Fibrin is the meshwork, the netting," Bowlin says. "It's like throwing a net over the clot that holds it together and keeps it from dissolving quickly." After the clot is formed a...Toxicogenomics provides insight on assigning breast cancer drugs
...g, but whether or not there is a continuous energy cascade or a plug, for a given cellular activity. As a result, he is able to look at a cell-signaling pathway globally. "This protein array is able to look at signal pathway profiling, cellular circuitry, and protein-protein interactions on a chip, to look ...Meeting the nitrogen management challenge: Arresting the nitrogen cascade
... growing population, but the element also starts a cascade that moves through the atmosphere, soils, and waters, dramatically altering the environment. In order to meet future need and preserve the environment, new strategies and opportunities for improved nitrogen management must be developed, scientists ......lled c-Fos, which are critical for stimulating the cascade of events that lead to bone-cell differentiation. Since alphaV beta3 integrin also is known to contribute to the activation of ERKs and c-Fos, the team concludes that the alphaV beta3 integrin and M-CSF collaborate in the process of osteoclast differ...