Gold quantum dots have applications in biological labeling, nanoscale optics
...onalize these quantum dots so they will get across cell membranes, seek out specific proteins inside a cell and label those proteins," explained Dickson. "We are basically developing the tools for in-vivo, s...Researchers find clues about how antibodies specialize
... leaving the rest of the genetic material in the B cell untouched -- has been a mystery. In the biochemi...regulation is impaired for some reason, then the B cell would incur a lot of random mutations and that might lead to tumors." The next step, then, is to fi...New compound could give some types of cancer the one-two punch
...within three days, Li said. "This compound stopped cell division in its tracks," he said. OSU 111 induces apoptosis cell suicide in cancer cells because it keeps key structures called microtubules from working during cel...U of T study identifies possible stem cells in pancreas
...fe of the organism and some ability for the parent cell to generate varied cell types for example islet cells and exocrine cells. Pancreatic stem cells could provide a plentiful s...Virus known for its photo ops makes its movie screen debut
...ters its shape as it prepares to pierce its host's cell membrane. The complicated infection process requir...When the T4 approaches "touchdown" on an E. coli's cell membrane, the baseplate's proteins unfold in a complex motion, opening like a flower's petals and ch......efore manipulates the so called MLO protein in the cell membrane of Barley cultivars that is encoded by the corresponding Mlo-gene in the genome.Although laboratory experiments with mutated mlo-genes confirmed a correlation to the resistance, the detailed genetic analysis revealed no causal differences be...Study suggests cell-cycle triggers might be cancer drug targets
... removing three key proteins believed essential to cell division and growth had little impact on normal ti...ns, when overly active, have been linked to cancer cell proliferation. With one significant exception, the absence of proteins called cyclin D1, D2, and D3 ...Newly discovered protein may be key to muscular dystrophy
...sue of the journal Nature. Normally, a nerve cell induces a muscle cell to contract by releasing the neurotransmitter acetylcholine at the synapse -- the junction where the...New clues to hereditary blinding disease found
... rhodopsin will misfold and break down, triggering cell death, degeneration of the retina and eventually blindness," said John Hwa, MD, PhD, assistant professor of pharmacology and toxicology at Dartmouth Medical School. "What is especially exciting about this new direction in our research is that this c...Enzyme activation appears key in helping internal clock tell night from day
...rtha U. Gillette, a professor in the department of cell and structural biology in the U. of I. College of Medicine at Urbana-Champaign. The research was done in her laboratory.......staff scientist in December. Kay is a professor of cell biology and the director of the Institute for Chil...experiment to see if expressing the new genes in a cell could change the expression of known clock genes. To do this, they used a biochemical assay to detec...Sweet success in targeting sugar molecules to cells in living animals
...n whole animals so that they can differentiate one cell from another. The researchers said the new approac...target the delivery of chemical agents to specific cell types in living organisms more precisely. Led by Howard Hughes Medical Institute Medical Institute i...Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
..., Mayo Clinic researchers transformed these master cell types into fully functional cardiac cells and tran... study, entitled "Stable benefit of embryonic stem cell therapy in myocardial infarction," appears in the August 2004 edition of the American Journal of Phy...When is a mouse like a test tube?
...e to label cells for diagnostic purposes. In early cell culture experiments reported in 2000, Bertozzi sho...in turn is incorporated into sugar polymers on the cell surface. More importantly, the more azide-sugar she fed cells, the more appeared on the surface. In ...The first engineering of cell surfaces in living animals
...; it has proved valuable in fundamental studies of cell interactions and in the development of new techniq...remodeled cells of living mice. The ability to tag cell surfaces in living beings may someday allow the targeting of specific kinds of cells for noninvasive...New model can aid in understanding immune system diseases
... The advance builds on previous UI studies done in cell culture and provides researchers with a model that...mbrane protein 1 (LMP1), which in turn can cause B cell lymphoma, or tumors, Bishop said. The new mouse model will help researchers study how LMP1 impacts s...Other highlights in the August 18 JNCI
...sease's prognosis. In a new study of neuroblastoma cell lines and tumor samples, Manel Esteller, M.D., Ph....cogenic RET signaling is associated with decreased cell viability and cell proliferation in vivo , which indicates that RET stimulates cell proliferation a...New mechanism for display of foreign proteins to immune system
...n a process called crosspresentation, the sentinel cell internalizes foreign proteins, called antigens, fr...into tiny fragments that are then displayed on the cell surface. Through this display the sentinel cell can then stimulate special immune cells called cytot...Progress in breast cancer progression
...ow that a protein called NF-kB, which works in the cell by turning on a variety of other genes, is involved in tumor progression when its activity in the cell is altered. The authors showed that NF-kB is essential for the initial transition stage called epith......uthors found that there was an increased amount of cell death in these tissues, both through necrosis and programmed cell death, called apoptosis. These data indicate that AMPK is responsible for altering cellular mechani...