Tag: "cellular" at biology news
NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways
...ing new therapies based on promoting or inhibiting cellular
behaviors. A particular strength of the Center is its emphasis on the use of activity-based proteomics to profile protease function. This approach, developed by Dr. Bogyo at Stanford, marks an innovation over other proteomics strategies because the ...
Rare childhood genetic syndrome identified
... most important signaling molecules, and normally, cellular
calcium levels are tightly regulated. Dr. Mark Keating, senior author of the study and a Howard Hughes Medical Institute investigator at Children's Hospital Boston, likens the calcium channel to a screen door. "After you go through the screen door,...
Chemical derived from vitamin-E shows early promise as cancer drug
...t it impacts on numerous anti-growth and pro-death cellular
processes in cancer cells but not normal cells," s...ine will continue analyzing alpha-TEA activity and cellular
effects in mice. Meanwhile, the chemical is going through more detailed toxicity evaluations and ana...
Pack-MULEs are toting a new look at plant evolution
...hose, Jiang has found that some carry fragments of cellular
genes with them and were dubbed Pack-MULEs. No one can say scientists don't have a bit of poet in them. Genome sequences are long it takes 430 MB (that's 430 million base pairs) to hold the genome sequence for rice so most of the time scientists e...
New molecular link key to cellular proteins involved in cancer progression, other diseases
...sts has discovered the molecular mechanism used by cellular
proteins that are known to be involved in cell dev...me types of cancer," said Zhang. By dividing human cellular
extract into smaller and smaller fractions, the UNC scientists were able to isolate and identify the...
Award winning researchers reveal potential new role for Glivec
...Belgium and Switzerland set out to see whether the cellular
genetic and kinase profiles in DFSP would correlate with clinical responses to imatinib. The ten patients were treated with 800mg of imatinib daily. Of the eight with locally advanced disease, two achieved complete response that was pathologically co...
Pacific Northwest team unveils largest virus proteome to date
... the immune system--that it's using the body's own cellular
proteins as camouflage. Before this study, a comprehensive analysis of the proteins that constitute the HCMV virion had not been possible without the development of new proteomics technologies in the PNNL lab of Richard D. Smith, a Battelle F...
Gene clusters predict atherosclerosis severity, susceptibility
...le those related to susceptibility tend to mediate cellular
responses that occur prior to the inflammatory process. "While the methods we used to identify these genes do not have immediate clinical applications, they do play an important role in identifying genes for further study," Seo said. "The i...
UCSF scientist Joe Derisi named MaCarthur Fellow
...on, beginning with genes that correspond to normal cellular
processes and ending with highly specialized functions for invading red blood cells. The discovery of the pronounced level of activity, in which a gene is transcribed into messenger RNA on the path toward producing a protein, points to nu...
Rice finds 'on-off switch' for buckyball toxicity
...ell scientists what happens inside the body, where cellular
repair mechanisms, whole-organ and whole-body processes come into play. "Cytotoxicity should not be confused with a full-fledged toxicological risk assessment," said Kevin Ausman, CBEN executive director and a co-author of the paper. "Risk assessment...
UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
...l molecules; Robinson's laboratory tested them for cellular
toxicity and anti-HIV activity; and Weiss' laborat...hers to determine whether Nef was binding to three cellular
proteins, as is Nef's function. (Although Nef is able to bind well to the three proteins in the abse...
Brown research reveals key insight into memory-making
...sue of Science , fills in important details about cellular
changes that occur when experience becomes memory....n last hours, even days, and is believed to be the cellular
basis for memory. AMPA receptors on the membrane of the information-receiving neuron, known as the p...
$7.5 Million grant to Yale researchers for role of viruses in cancer
...continue studies on the role of viruses and mutant cellular
proteins in tumorigenic transformation of cells. ... studies to understand how viral genes and related cellular
genes cause cells to escape normal growth controls and induce cancer. "Because viruses are so wel...
Key cell-death step found
A fundamental cellular
event related to programmed cell death has been de...odi Nunnari, a UC Davis professor of molecular and cellular
biology. Mitochondrial fusion was tricky to understand because mitochondria are structurally comple...
Environmental decontamination, greenhouse gases, and the genome of a methane-loving bacterium
...on the availability of molecules needed to sustain cellular
activities. Most surprising, the researchers note, was evidence that this methane specialist can turn into a sort of metabolic generalist-with a capacity to use sugars, hydrogen, and sulfur-and appears able to survive reduced oxygen levels. The ...
Research suggests new avenue for stopping, preventing colon cancer
...) have provided the first evidence that blocking a cellular
receptor can inhibit the development of pre-cancerous colon polyps in mice. The research suggests a new avenue for stopping or preventing colon cancer, which kills more than 50,000 Americans each year, said the paper's senior author, Raymond N. DuBoi...
Information system to help scientists analyze mechanisms of social behavior
...researchers in three broad areas: systems biology, cellular
and metabolic engineering, and genome technology. "We are pleased to provide the institutional support for BeeSpace, which will be a flagship project for the institute," said Harris Lewin, IGB director and professor of animal sciences. "We are putti...
New way to protect brain from stroke damage
...cium overload, long attributed to another group of cellular
components, is essential for stroke injury as it s...y. Scientists had long considered another class of cellular
components, NMDA receptors, as the main target responsible for calcium overload in the ischemic brai...
Washington University in St. Louis leads group studying aging process
...ancient little blue-green algae). Looking at the cellular
systems in cyanobacteria, and then in a model plan...on (redox) processes, and are key culprits causing cellular
aging. Cyanobacteria are organisms that gave rise to chloroplasts, the oxygen factory in plant cells...
JCI table of contents September 15, 2004
... by the death of retinal neuronal through a form a cellular
suicide called apoptosis. In many cases the vascul...ling. Understanding of donor-host interaction at a cellular
level, however, is currently limited. To gain insight into this system, Loren J. Field and colleague...
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