UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
...search, is lead investigator for the team studying central regulators of energy metabolism. The molecular biology of energy metabolism will be headed by Dr. Horton, while Dr. Craig Malloy, professor of radiology and internal medicine, will oversee the in vivo intermediary metabolism team. Dr. Scott Grundy, d...Cardiac arrest may hinder ability to learn certain tasks
... neurons involved in sending signal throughout the central nervous system and the body. There was an overall 18 percent decrease in dendritic spine density in the hippocampus in the cardiac arrest mice compared to the control mice, a finding that represents a functionally significant loss, DeVrie...Researchers devise potent new tools to curb ivory poaching
...ns with flights over the open savannas of eastern, central and southern Africa, but it is much harder to do the same in the dense forests of central and western Africa. Those forests are where elephants are currently being slaughtered wholesale, sai...NSF awards 22 new projects for plant genome research
...re and function of maize centromeres, which play a central role in cell division and ensure that the newly divided cells each receive a set of chromosomes. A growing challenge is how to handle the massive amounts of data coming out of ongoing genomics projects and to make it readily accessible to the broa...Targeted therapy knocks out pediatric brain cancer in mice
...Cancer Cell. "Therapy for pediatric cancers of the central nervous system has not improved significantly in the last three decades," explains study author Dr. Tom Curran from St. Jude Children's Research Hospital in Memphis, Tennessee. "This is partly due to the absence of adequate model systems for testing ...New sign language suggests children create language's fundamentals through learning
...ts," Senghas said. The researchers studied a trait central to all developed languages called "discreteness," meaning that information is packaged into separate elements that can be put together according to various rules. For example, no matter what the language, it consists of words, which combine to make s...Can an old gene learn new tricks?
...the Hmx gene was limited to the development of the central nervous system (CNS). Dr. Thomas Lufkin from the Genome Institute of Singapore and colleagues show that the mouse Hmx2 and Hmx3 genes have apparently interchangeable functions in CNS development and have overlapping yet distinct functions in the dev......e on epithelial characteristics, demonstrating the central role of this GTPase in somitogenic MET. These find... somite-forming cells and the demonstration of the central role played by cytoskeleton-regulatory molecules in the cell shape changes characteristic of the mes...Two Virginia Tech energy-related inventions win R&D 100 awards
...om multiple well sites throughout the world from a central location. "This could pave the way for smart oil fields, with sensor highways connected seamlessly for password- or encryption-protected monitoring from any Internet access site," says Pickrell. "This can revolutionize the oil services market." He al...Cell's gatekeeper for ammonia revealed in unprecedented detail
...posure to ammonia. Advanced liver failure disrupts central nervous system function when ammonium ion concentrations are elevated, research shows, so the channel's high efficiency is vital. Each channel threads in and out of the cell membrane 11 times and is structured so that no ammonium ion, NH4+, nor any o...News tips from the Journal of Neuroscience
...ccess, but it only appears in mammalian axotomized central neurons when axons are within a permissive peripheral nerve graft. The fish homolog L1.1 is upregulated after spinal transection, and is thought to aid in their robust axon regeneration and functional recovery. Without L1.1, brainstem neurons did not...Common cold virus can cause polio in mice when injected into muscles
... from the calf muscle where it was injected to the central nervous system along "motor neuron axons." Such axons extend from the central nervous system to muscles throughout the body and convey commands for muscle movement. The site in t...$18 million bioinformatics center to become weapon against deadly diseases
... Rick Stevens, who will co- direct the center. "A central goal of the center will be to gather all existing data on these organisms and embed this data within a framework that will support researchers in their efforts to understand them," said center Co-Director Ross Overbeek. Working together at the cente...Natural mineral locks up carbon dioxide
...s, each plant could pipe their carbon dioxide to a central treatment plant. ...Battle between bubbles might have started evolution
... of fatty acids and other lipids, plus proteins. A central question in evolution is how simple versions of these cells, or vesicles, first arose and began the process of competition that drove the evolution of life. "Most of the previous thinking about how cells grew and evolved was based on the idea of the...APS awards more than $140,000 to minority students of physiology
...ts of excess oxygen on electrical signaling in the central nervous system (CNS). This research will help elu...AMP-dependent kinase, a family of enzymes that are central to physiological functions including energy metabolism, water homeostasis, gene expression, and musc...How an insidious mutation fools DNA replication
...chemists have pinpointed how a flaw in DNA that is central to mutations in cancer and aging fools the cellular enzyme that copies DNA. Their finding explains how oxidative DNA damage -- a process long believed to underlie cancers and aging -- can create permanent genetic damage. The Duke University Medical C...Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
...fective treatments for it. "Dendritic cells play a central role in the generation of antitumor immune response," says Coukos. "As a result, it was believed that these were mostly good players in inducing tumor rejection." But when dendritic cells are part of the tumor microenvironment, instead of stimulating...Review article makes case for a new source of cells in the body
...y tissue, the first of which may be connecting the central nervous system with its target tissues, noting how the cells travel with nerves then move ahead of them as if showing the way. "Nerves could be following certain cues left behind by VENT cells," Dr. Sohal says. "That is what we think. We have to expe...Researchers uncover secrets of immune system's munitions factory
...take its antigen cargo and how to dispose of it. A central mystery in the field of immunology, said Alt, has been how AID acts on antibody genes. In previous studies, Alt and his colleagues showed that the enzyme acts on single-stranded DNA and that, for class switch recombination, such single-stranded DNA c...