JCI table of contents, 15 June 2004
... Cancer Human plasma cell neoplasms develop when certain blood cells, called plasma cells, become cancerous. Multiple mylomas are the most common form of this type of cancer. Plasma cell neoplasms are difficult to study they often develop through the interaction of more than one mutated gene, and currentl...Conflicting views on embryonic and adult stem cells complicate research in stem cell therapeutics
... recipients. Some groups have found, however, that certain ASCs do not cause immune rejection, allowing cells to be pooled from many patients, which would solve this problem. Though biological hurdles are common ground for both ASCs and ESCs, the latter face political barriers because they originate from dis...Whole body imaging allows better understanding of the immune system
...or his contributions to understanding the cause of certain blood cancers and immune disorders, findings that have led to the development of improved therapies for patients, including a widely used molecularly targeted therapy for chronic myeloid leukemia (CML). But now, combining his experience as a...Existing drug may prevent brain injury and seizures in newborns
..., they investigated whether compounds that block a certain type of glutamate receptor, known as AMPA, can dampen the harmful effects of excitotoxicity in the immature brain. The first study, published in the May 5 issue of The Journal of Neuroscience, examined a type of brain damage called periventricula...UCLA researchers recreate patterns formed by mammalian cells
...evenly spaced patterns in early development or how certain diseases may trigger cells to create lesions in sp... better control them, leading to new ways to treat certain conditions like heart disease," said Demer....Genetic modification in mice lowers cholesterol and homocysteine by half
...standing how the body regulates the manufacture of certain lipids and their functions in the human body. The new study reported at ASBMB focuses on the two methods or pathways by which the liver makes phosphatidylcholine(PC), the key building block of cell membranes in humans and other animals - and an impor...Canine word-learning research published in Science
...for Rico to put toys in boxes, or to bring them to certain people. Fischer noted that people should not take this study as a reason to go out and get a Border collie as a novelty. "Border collies are working dogs," Fischer said. "If they were humans, we'd call them workaholics. They are high-maintenance, pro...Alzheimer's may leave some forms of memory intact
... despite the damage to these areas in Alzheimer's, certain memory processes that seem to depend on them remain fundamentally intact." The researchers found that the reduction in time required to perform the classification task correlated with a reduction in activity in frontal cortex. This reduct...Carnegie Mellon computational biologist Russell Schwartz receives prestigious CAREER award
...c targets so that they would be selective only for certain problems and unlikely to cause system-wide side effects inside the body. The grant also will support his efforts to develop novel strategies to teach advanced methods for biological modeling and simulation, as well as to prepare a more general biolo...Thimerosal, found in childhood vaccines, can increase the risk of autism-like damage in mice
...ic predisposition affects risk in combination with certain environmental triggers. The study was conducted by researchers at the Jerome L. and Dawn Greene Infectious Disease Laboratory at the Mailman School of Public Health, Columbia University. Over the past 20 years, there has been a striking increase--at...Parting genomes: UA biologists discover seeds of speciation
...everal researchers have identified mutant forms of certain genes associated with the inability of fruitflies to hybridize with closely related species, but in all cases those genes were discovered long after the two species diverged. Those genetic changes could have caused the speciation or resulted from it,...Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies
... "Our findings suggest MPA may be affecting certain neuroendocrine systems in a very different way than natural progesterone," explained Dr. Pazol. "In comparison to natural progesterone, MPA binds to glucocorticoid receptors with a much higher affinity and may have a greater impact on the brain's str...Researchers develop blood test that can detect genetic changes in progressive breast cancer
...ed a blood test that can detect amplification of a certain gene found in circulating cells associated with br...cells, doctors may be able to provide Herceptin to certain patients who have acquired such amplification. At present, HER-2 amplification is only diagnosed i...Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
...ng out genetic experiments to test their idea that certain non-ribosomal proteins that regulate ribosome assembly (called ribosomal assembly factors) also regulate cell proliferation. "We think that specific ribosome assembly factors we discovered might have a second 'moonlighting' job," said Woolford. "Thus...When combining new oral anti-cancer agents with standard chemotherapy, timing may be crucial
...llicles. Erlotinib, in contrast, works by blocking certain signals that cancer cells need in order to reach the cell-division stage, or mitosis. Gumerlock theorizes that when erlotinib is given simultaneously or just before docetaxel, fewer cancer cells reach mitosis and become vulnerable to chemotherapy, t...Tiny tango: Device sorts microscopic particles with speed and precision
...mical engineering methods to create particles of a certain size, but once you have done that there is not a lot you can do to filter out exact sizes and check the quality," Sturm said. Huang said the device could also result in improved ink jet printers, which produce better results if the ink par...Corals can reestablish symbiosis with algae from their environments after bleaching
... them and help supply them with food. But certain environmental stresses, such as high or low light or sea temperatures, can lead to a reduction in algal densities or loss of pigmentation, leaving the coral's white skeleton visible through the clear tissue. "Our data show that corals have ...When blood can't get to brain, special CT scan helps
...oing to be a terrific adjunct in the evaluation of certain patients with risk factors for stroke, especially those critical patients in whom an expeditious decision is needed," says co-author Gregory Thompson, M.D., an associate professor in the U-M Department of Neurosurgery. "I think it will become increas...UCSD study shows how we perceive world depends on precise division of labor among cells in brain
...ponded to multiple electrical impulses arriving at certain frequencies. "While some neurons only responded ...ple sources, but is only selectively responding to certain information about the timing or frequency of the impulses it is receiving. Why is the timing of info......s of evolution, in which amphibians have developed certain types of behavior for specific reasons. Some species lay their eggs in warm, shallow waters because they are seeking sun and heat, and they need to hatch and grow quickly before the water evaporates or freezes. "Those types of behavior do not change...