Genetic differences might help distinguish thyroid cancers
...e genetic differences can be done using polymerase chain reaction (PCR) technology, which is far more available and far less costly than microarray analysis. Other Ohio State researchers involved in the study were first author Micheala A. Aldred, Sandya Liyanarachchi, Natalia S. Pellegata, Sissy J...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...al or viral infections. In turn, NF-kB sets off a chain of reactions that lead to cancer. Mice used in the new study were given colon or breast tumor cells which metastasized to the lung. Some of these cancer cells served as "controls," while other cells were given a protein that specifically inhi...Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
...ts that accumulate significant levels of very long chain poly-unsaturated fatty acids (PUFA) in seed. This ... report of the successful engineering of very long chain PUFA into an oilseed crop, and is an excellent example of how genetic engineering of agronomically i...Genetic analysis rewrites salamander's evolutionary history
... Appalachians because the southern portion of that chain has the greatest diversity of species. The new fam...mother, and therefore represent an unbroken female chain going back perhaps 100-150 million years in plethodontid salamanders. By looking at mutations in the...Protein fishing in America: The movie
...gainst one-another is the critical first step in a chain of events that rule all subsequent cellular behavior. But this vital exchange between single molecules has defied direct observation because that line-flicking and message-passing happen randomly at such a small scale. A Pacific Northwest National La...Scientists reinvent DNA as template to produce organic molecules
...selections can then be copied using the polymerase chain reaction (PCR). The application of DNA-templated synthesis has enabled a collection of DNA strands to be transformed into a corresponding collection of sequence-programmed small macrocyclic molecules with potentially interesting chemical and biologi...Using statistics to decipher secrets of natural mutation
...tistical technique that they call "Bayesian Markov chain Monte Carlo sequence analysis." Basically, the technique enables them to feed in sequence information from genomes of different organisms and discern patterns that can distinguish models of mutational mechanisms. According to Green, the statistical ...Evolvability could be a driving force in drug resistance
...etic mutations occur. Random changes along the DNA chain are now understood to be only one way that organisms evolve. Mutations also occur based on genetic recombination, genetic transposition and horizontal gene transfer. With these mechanisms, relatively large chunks of genetic code are shuffled or subst...JCI table of contents, 2 August, 2004
... striking specificity for the loss of myosin heavy chain only. Intriguingly, TNF-alpha/IFN-gammadependent loss of myosin heavy chain occurred through different mechanisms depending on whether they were examining it in cell culture or...... striking specificity for the loss of myosin heavy chain only. Intriguingly, TNF-a/IFN-gdependent loss of myosin heavy chain occurred through different mechanisms depending on whether they were examining it in cell culture or...New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
...n might result in significant differences in sugar chain expression by the SARS viruses. To clarify whether...logical tools. Glycan arrays to exploring "sugar chain signatures" of infectious agents Wang and Lu emphasize the importance of studying the antigenic car...DNA tests point to extinction of 2 distinctive arctic bird populations
...d ranges and the other in Alaska's Aleutian Island chain are genetically distinct from all other rock ptarmigan and should be considered separate species. "Traditional classifications often fail to capture the diversity and evolutionary history of organisms below the level of species," Dr. Montgomerie exp...Antimalarial substances found in New Caledonian sponges
...chemical skeleton. They all carry a lateral poly-N chain and a variable-length carbon chain (3) . Phloeodictines types B and C, which are minority compounds, carry an additional sulfurated po......d cellular defenses is unleashed through a complex chain of molecular events, triggered by master control proteins. These control proteins act as recruiting officers, rallying other proteins to set up the inflammatory defense. One of the most important molecular sergeants is a protein called nuclear factor......NA amplification that could replace the polymerase chain reaction (PCR), a technique that is invaluable for both medical diagnostics and basic research but which is confined to the laboratory. In the August issue of EMBO reports, Huimin Kong and colleagues at New England Biolabs (Beverly, MA, USA) describe...Study suggests first molecular target to halt spread of HPV
...des a specific pair of proteins in HPV may break a chain that, left unhindered, promotes cellular proliferation and, potentially, cervical cancer," said Gary Clawson, M.D., Ph.D., professor of pathology, and biochemistry and molecular biology, Penn State College of Medicine. "Until now, there have been no ...UNC research accelerates discovery of novel gene function
...solation and amplification, such as the polymerase chain reaction, or PCR, procedure. The method, designed by Kafri and gene therapy center researcher Hong Ma, enables scientists to rapidly screen cells for changes in a particular phenotype. They can easily isolate and identify the gene causing the changes...As humans alter land, infectious diseases follow
...hange or extremes, the report notes, can trigger a chain of events that manifests itself in the emergence of new diseases. An example cited in the report is the emergence of nipah virus in Malaysia and Singapore in 1999 when El Nino-fueled fires are thought to have driven fruit bats from their forest habit...UK small firms pay lip service to green issues
...re management activities. At the top of the supply chain in the building sector, architects claimed that whilst lip service was paid to sustainability issues within the industry, there was currently little in the way of environmental design occurring in the UK. Several admitted that they would not push the...Scientists discover new role for tiny RNA in plant development
...in. Structurally, RNA is a polymer consisting of a chain of phosphate, sugar and nucleotides. The most common type of RNA, messenger RNA, contains thousands of nucleotides and is the genetic blueprint that cells use to combine amino acids into proteins. MicroRNAs are much smaller, typically only about 20 n...