Tag: "channel" at biology news

JCI table of contents, December 15 2003

...ter Nijmegen, The Netherlands, show that the TRPV5 channel acts as the molecular gatekeeper in facilitating Ca2+ reabsorption in the kidney. Despite enhanced vitamin D levels, mice lacking TRPV5 displayed diminished active Ca2+ reabsorption, which caused severe hypercalciuria. In TRPV5/ mice, Ca2+ reabsorpti...

Scientists identify molecular step that causes intoxication

...d the brain protein it codes for - known as an ion channel - are responsible for the intoxicating effects of ...ome. "We have found that alcohol acts on this channel in nerve cells to cause neural depression and intoxication," said Steven McIntire, MD, PhD. "We woul...

Easily paralyzed flies provide clues to neurodegeneration

...nd mosquitoes. Moreover, the type of ion channel deficiencies found in some of Ganetzky's fly mutan...dwide are now investigating Herg and the potassium channel protein it encodes. Such discoveries have engendered significant interest on the part of the ...

UT Southwestern researchers' discovery may lead to gene targets for new form of contraceptive

DALLAS Dec. 1, 2003 Deleting a particular ion channel from sperm cells causes those cells to lose the po...ene that contains a putative calcium-permeable ion channel identified in earlier research as CatSper2 did not change normal sperm cell production or basic sp...

Calcium channels control coronary artery relaxation

...rs have discovered that a specific type of calcium channel -- a pore-like protein that nestles in the cell me...hers hypothesize that drugs targeting this calcium channel might one day be used to treat cardiovascular disease by opening arteries. The researchers, led by H...

Calcium channel involved in coronary artery relaxation

...cientists understand how a certain type of calcium channel helps coronary arteries to relax. The study, repor...diovascular Center, tested how loss of the calcium channel affected blood vessel contraction. Losing this channel did not seem to impair blood vessel contracti...

Roderick MacKinnon wins 2003 Nobel Prize in Chemistry

...ed biophysicists for decades: How does a potassium channel admit millions of potassium ions per second, while...he DNA sequence of a potassium channel--the Shaker channel in fruit flies--in 1987. But even with the DNA sequence in hand, which allowed researchers to assign...

JCI Table of Contents, 1 October, 2003

...tations in the alpha subunit of the cardiac sodium channel gene (SCN5A) a gene previously associated with ca...tations in this gene demonstrated a loss of sodium channel function, predicted to reduce excitability of the heart. This study reveals that congenital SSS, in ...

When heme attacks: After trauma, the molecule that makes life possible rampages

... relaxation and neuron excitability." Maxi-K is a channel that moves potassium ions out of cells. In the Nature paper, Tang and his colleagues prove that the Maxi-K protein possesses sites that bind heme. If these sites were removed or altered, heme could not effect Maxi-K proteins. "Maxi-K is found in th...

Researchers solve the mystery of a key structure in immune system cells

...archers are hopeful that now that the role of this channel of communication has been identified, it may serve as a potential target for treating diseases -- those in which the body attacks itself, such as in arthritis, as well as those in which the body doesn't recognize the attacker, such as tumors. "This c...

Old drug works new tricks for iron overload heart disease

...c levels worldwide." Oral medications like calcium channel blockers amlodipine, verapamil and diltiazem were ...e to understand who benefits the most from calcium channel blockers and how much to use. "Since the drugs being considered have already been approved for human...

JCI Table of Contents

...f the b subunit of the calcium-activated potassium channel in vascular cells is critical for maintaining vasc...or role in relaxing arterial smooth muscle. The BK channel is comprised of an alpha and beta subunit. Calcium release within the myocyte activates the BK chann...

JCI Table of Contents, 15 August 2003

...alancing act in the kidney The epithelial sodium channel (ENaC) consists of alpha, beta, and gamma subunits present in many configurations, and facilitates sodium reabsorption and potassium secretion. ENaC regulation takes place in the kidney in the aldosterone-sensitive distal nephron, which comprises the...

Modifier gene controls severity of neurological disease in mice

...thin a few weeks of birth. Called Scnm1 for sodium channel modifier 1, the gene is one of a small group of re...of Science . Meisler's research focuses on sodium channel genes that control the flow of electrical signals between nerve and muscle cells. Mutations in sodiu...

Development of hair depends on development of the hair channel

...rotein called GATA-3 as a possible trigger of hair channel development. Based on its location within the hair...discovery of a genetic connection between the hair channel and hair: without GATA-3, the mice grew an unusually short and stubby coat. "This study illustrates...

How old mice get bright again

...tic standpoint that interference with a single ion channel subtype can overcome certain age-dependent memory ...dicine, says. "Our data suggest that increased SK3 channel expression in the hippocampus of aged mice represents a mechanism, which contributes to the age-depe...

Portrait of a doomed Sea

...ter levels have so far defeated these efforts. The channel connecting the two should soon dry up anyway, preserving the Small Aral Sea at least. Meanwhile researchers are studying the salty Aralkum Desert effectively the newest land surface on Earth to see how best to promote plant growth and stabilise the...

Science Picksleads, feeds and story seeds (July 2003)

... who is responsible for maintaining the navigation channel in the Columbia River, often discharge dredged materials back into the river. While white sturgeon populations in the lower Columbia River are probably the healthiest stock of sturgeon in the United States, even supporting limited commercial and spo...

U.Va. researchers discover mechanism for the regulation of low-voltage-activated calcium channels

...f G-protein subunits binds directly to the calcium channel protein to inhibit channel activity. "These studies identify the T-type calcium channel as a new target for G-protein beta ...

New technique for sorting sperm could improve fertility treatment

...d eventually diverged. Sperm were sent through one channel and a saline solution through another channel. When the channels met, the motile, or healthy, sperm were able to cross over to the other stream and exit through the second channel, while the nonmotile sperm stayed their course through the first chann...

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