Tag: "channel" at biology news
Phenotypic variability in cystic fibrosis
...modifiers. In particular, while CFTR, the chloride channel
missing in affected individuals, is normally expre... in intestinal biopsies confirm that high residual channel
activity characteristic of CFTR is a reasonable predictor of mild disease. Such residual activity is...
Study helps identify key step in simple motor learning
...urface of the cell. That binding, in turn, opens a channel
in the cell's membrane that lets various charged a... glutamate and bind it less efficiently. Also, the channel
opened by glutamate could let ions through more slowly than normal, or it could be open for a shorte...
Study: control of chloride channels localized, discovery may boost cystic fibrosis treatment
...ingbo was able to use the activity of the chloride channel
itself in conjunction with biochemical reagents as...ed for physiologic regulation of the CFTR chloride channel
were present in very small pieces of membrane with the CFTR molecule. The work suggests the presen...
Link to our ancient past is confirmed in potassium channel research
...ject in which the pore of a prokaryote's potassium channel
(the interior core of the channel) was substituted for the pore of a potassium channel
in a euokaryote. The scientists found that the eukarotic channel
continued to function essentially a...
Researchers describe atomic-size 'sorter' that performs vital cellular function
...ure. The image shows the selectivity filter of the channel
that only the potassium ion can use to cross the c... conditions within the body. "We know the overall channel
structure will be similar in channels that conduct potassium, sodium and calcium ions, but the chemi...
UFS Mcknight Brain Institute researchers: Pioneering spinal cord procedure appears safe
...ereby restoring communication along the bodys main channel
for transmitting nerve system signals. After noting promising results in rats and cats, the UF team designed a small study to test the procedures feasibility and safety in humans. Since their transplant surgeries, the first two patients have remaine...
Invasive gobies prevent sculpin spawning, impacting perch food chain
... first spotted in 1990 in the St. Clair River, the channel
connecting Lake Huron and Lake St. Clair. Since then, the aggressive, robust fish has expanded its population throughout most of the Great Lakes. Now, experts are concerned that the goby will spread from the Great Lakes water basin to the Mississip...
Changes in Lake Erie fish population suggest lake's recovery
...nditions: Tolerant species included black crappie, channel
catfish and common carp; intolerant species included smallmouth bass, lake whitefish and minnows. The researchers used the abundance of signal species throughout the years t...
Exploding eggs and rare human disorder help explain water regulation
...tein aquaporin because it acted as a pore or water channel
through which fluids flow in and out of the membrane. Since the exploding frog eggs, scientists have identified 10 aquaporin proteins in the more water-permeable parts of the body -- the moist surface tissues of the alveoli in the lung, tubules in t...
Get 'Research on the move' with BioMed Central
...r Palm, Handspring or Pocket PC). The BMC Research channel
uses AvantGo software to update a user's handheld device with the latest research abstracts, published in BioMed Central's online peer-reviewed research journals, every time they 'sync'. A link to the full text of any article of interest can then be ...
Murine model of human hyperinsulinism
...r and colleagues have thus identified the KATP ion channel
as a novel target of Foxa2 in pancreatic b cells. Another interesting observation made by this research team is that mice deficient for Foxa2 in b cells also display a decreased level of glucagon secretion from a cells. Taken together, this work prov...
Structural studies reveal how potassium channels are inactivated
...ails, called inactivation gates, at the end of the channel
can slide into the channels pore and shut it down....e openings that are located above a portion of the channel
that juts into the cells interior. Those experiments showed that the side windows offered a potentia...
Toxic compound opens potentially important cell gates
...become fused with a protein that creates a calcium channel
known as LTRPC2. A key segment of the disposal pro...-clamp" technique to test whether LTRPC2 created a channel
and whether that channel
could be regulated with ADP-ribose. He found that the answer to both quest...
Penn paleontologists locate a new genus of colossal dinosaur along an ancient coastline
... the herbivore was standing on the edge of a tidal channel
in very shallow water when it perished 94 million years ago. "The discovery of a huge sauropod, especially in a near-shore environment, is of great interest," said Hans-Dieter Sues of the University of Toronto and Royal Ontario Museum, who was not in...
Researchers' description of the regulation of a new family of ion channels may open doors for therapies for a variety of conditions
... paper describes a regulatory mechanism for an ion channel
called LTRPC2. This regulatory mechanism involves...hanisms for another ion channel, LTRPC7. This ion channel
appears to be controlled by normal levels of the molecule ATP (adenosine triphosphate), the power so...
Secret channel holds key to metabolic mysteries
...the University of Hawaii, they discovered that the channel
is sensitive to the presence of a chemical complex...ypoglycemia (sugar deficiency). "We had hoped the channel
might be capable of passing calcium ions," Nadler said. "That proved to be the case. In collaborat...
Color vision out of the corner of the eye
...he anatomical origin and wiring of the blue-yellow channel
is understood but the basis of the red-green channel
is unsure. It is known that the retinal pathway responsible is the so-called midget system, in which...
Potential new anthrax therapy discovered
...rotective-antigen molecules form a doughnut-shaped channel
that enables lethal factor and edema factor to cro...protective-antigen molecule in an otherwise normal channel
may be potent enough to disrupt the entire channel. A mutant protective antigen, therefore, can bloc...
Sea grant researchers developing new stress test for fish
...have identified naturally occurring antibiotics in channel
catfish that may be a promising indicator for moni... an important component of nonspecific immunity in channel
catfish. Nonspecific immunity protects against many different diseases at once. Specific immunity pr...
Hopkins' Young Investigators' Day winners shine in the spotlight
...micals and a deadly toxin from sea snails to alter channel
structure and provide insights into its function. The work should help design specific drugs for epilepsy or heart arrythmias, he says, as well as develop biosensors for environmental toxins. Alessandra Boletta, Ph.D., was awarded the Alfred Blaloc...
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