Researchers create nanotubes that change colors, form 'nanocarpet' and kill bacteria
...changed to a permanent deep blue. The process also chemically altered the nanotubes so that they became polymerized, giving them a more firm structure. Polymerized, these nanotubes could change from blue to other colors, depending on its exposure to different materials. For instance, in tests with acids and det...Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
... enzyme bound to the two molecules that the enzyme chemically combines with to make folic acid. Based on these images of the enzyme and its interaction with other molecules, the investigators discovered how it manipulates pABA and DHPP. In addition, the images disclosed a potentially new antibiotic target with...22nd amino acid synthesized and added to genetic code of e. coli bacteria
...ovided Kyzycki's group with a small amount of this chemically synthesized pyrrolysine. "The sample that Michael's team produced was exactly what the chemical structure that we'd predicted said it should be," Krzycki said. The final step was to see if the translator enzyme for L-pyrrolysine would function normal...Optimizing protein's 'death domain' halts leukemia in laboratory study
...ical killer domain out of a pro-death molecule and chemically reinforced it, so we were able to get it into cancer cells and kill them." Loren D. Walensky, MD, PhD, of Dana-Farber and Children's Hospital Boston is the paper's first author and Gregory L. Verdine, PhD, of Harvard University, is co- senior author....How an insidious mutation fools DNA replication
...erase, the distortion disappears, meaning that the chemically flawed guanine will persist in the DNA strand. In further studies, Beese and her colleagues are exploring other types of DNA lesions and how they affect replication. These lesions include those caused by major carcinogens. The researchers also have d...What actually influences air pollution over the Indian Ocean?
...overing all seasons. The region is dynamically and chemically active because of the strong tropical sunlight, high humidity and the increasing anthropogenic emissions. The Indian Ocean Experiment (INDOEX) was an international field campaign during the winter monsoon period in 1999 to study how air pollution aff...Unicellular organisms contribute more nitrogen to ocean that reported earlier
...dant group of unicellular organisms that "fix," or chemically alter, nitrogen into a form usable for biological productivity. First identified about five years ago, these organisms about 7 microns in diameter are fixing nitrogen at rates up to three times higher than previously reported for the Pacific Ocean...Sweet success in targeting sugar molecules to cells in living animals
...ccessfully targeted unnatural sugar molecules with chemically unique functional groups onto the surfaces of cell...zido sugar made its way into the mouse organs, was chemically processed similarly to the normal sugar, and appeared on the cell surface. They also found that the ...UCSD researchers are first to demonstrate molecular link between inflammation and cancer
... a normal process the body uses to kill mutated or chemically transformed cells, as well as useful cells that have outlived their purpose. Evading apoptosis is one of the hallmarks of cancer. In their study, the UCSD team found that apoptosis was increased in mice bred without IKK beta. Specifically, without N...Related productivity tools complement computed tomography in lung cancer detection
...nsive MRI machines, Trimetaspheres can be modified chemically to make them soluble and attach to specific molecules that seek out cancer cells, or other targeted cells," says Technical Insights Industry Analyst Giridhar Rao. Such efforts are likely to receive a boost from the recently introduced ultrasound rese...Epilepsy: Signals 'brake' in brain impaired
...nal-Regulated Kinase, changes the channels present chemically in such a way that they no longer function. The consequence is, Professor Beck adds, that 'since the input signals at the dendrites reach the neuron largely unabsorbed, the rats probably react much more frequently than healthy rats by transmitting an...Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
...eir highly compact structure. Quantum dots can be chemically linked (conjugated) to molecules such as antibodies, peptides, proteins or DNA and engineered to detect other molecules, such as those present on the surface of cancer cells. The researchers injected human prostate cancer cells under the skin of m...Secret behind hard exoskeletons, spreading wings revealed
... sample to a laboratory at Harvard University that chemically sequenced it and sent back four short amino acid sequences of which the sample was composed. Using this sequence, Dewey, a post-doctoral researcher in Honegger's laboratory, ran searches on the genome of the fruit fly and found that three of the fou...New compound 'highly efficacious' at reducing human tumour growth
...s. The new compound, called 'ZK-CDK', is a novel, chemically synthesized small molecule ATP-competitive kinase inhibitor that is unique in that combines the inhibition of tumour cell growth as well as inhibition of tumour angiogenesis in one single molecule. ZK-CDK was shown to inhibit a range of CDK's as well...Measuring artificial viruses to improve disease detection
...esis.) They are constructed to be nearly identical chemically to real viruses but are encased with a protein covering to prevent degradation. The standards are currently used in research laboratories to help check analysis methods for detecting specific types of RNA, but the product has not been approved for cl...ORNL adds three R&D 100s to DOE lab-leading total
... few nanograms, allows only explosive molecules to chemically adsorb to a sensor that can identify the molecule. SniffEx is an improvement over other explosive detection products (such as gas chromatography/mass spectrometry and gas chromatography/surface acoustic wave devices) because of its sub-part-per-trill...Biologists ID defense mechanism of leading fungal pathogen
...of oxygen-trapping compounds. Flavohemoglobins are chemically similar to the hemoglobin found in mammalian blood, and Olson's team is trying to determine precisely how flavohemoglobin attacks NO, in hopes of finding a weakness that can be exploited with drugs. In addition to Candida, Gustin's group is also inte...Yale scientists visualize molecular detail of RNA splicing complex
...egments. "The structure reveals how RNA, which is chemically very different from protein, is able to use metal ions to achieve a very similar reaction mechanism," said Scott Strobel, "This argues for an evolutionarily ancient mechanism." Over twenty years ago scientists discovered that RNA, and not just protei...Functional genomics enables easy target identification and drives drug discovery
... compound is introduced into a compound library to chemically interconvert. It follows a target driven approach wherein, molecular building blocks are designed to react together selectively and covalently. With an increasing number of new molecular entities (NMEs) entering clinical trials by 2008, a 65 percent...New research at UNC shows ribosomes do not function as conventional enzymes
... matchmakers or readout devices rather than acting chemically to speed up reactions in the body the way enzymes .... "Enzymes, of which we have hundreds, participate chemically in the transformation of biological molecules by making and breaking bonds," said Wolfenden, Alumni ...