Unraveling a protein, researchers uncover mechanics of anti-cancer agent
...d, the proteins change their structures and expose chemically active groups. Once exposed, anastellin enhances the ability of the proteins to form networks. "The cells use anastellin apparently when it arises in half-unraveled FN-III-1 to strengthen the glue effect of the matrix," said Mu Gao, a doctoral studen...Technique may identify novel disease genes at a faster clip
... light, which caused a cross-linking reaction that chemically bonded the protein with its RNA target. The bond is so tight that the molecules could be isolated and identified together. Darnell and his colleagues made some enhancements that resulted in the development of their "cross-linking and immunoprecipitat...Golfing toward a greener environment
...ther application: placing ground-up rubber beneath chemically treated golf-course greens. Park says just under 1,000 pounds of pesticides are applied yearly to a single golf course. He adds that there are more than 23,000 golf courses in the United States. In the latest study, he and his team found that tire...Explanation offered for Antarctica's 'blood falls'
... Valley. But each of these lakes is very different chemically and the explanation for those differences has puzzled researchers for years. The water at the bottom of Lake Bonney, the most landward of the Taylor Valley three, is saturated with salts, Lyons said. But Lake Hoare a short distance down the valley fr...Fruits offer powerful protection from skin cancer
...adecanoylphorbol-13-acetate), a strong promoter of chemically induced skin cancer. Applying pomegranate extract (2 mg/mouse) onto the skin of neonatal mice 30 minutes prior to TPA (3.2 mole/mouse) application significantly inhibited TPA-mediated increases in skin edema and hyperplasia. TPA is an irritant and ...Improving the body's 'homeland security' against TB
...y evolved to dispose of pathogens by engulfing and chemically destroying them, are the major front-line defense ...a biologic process which one day could be mimicked chemically and therapeutically through the use of small molecules." In 2000, McKinney and his colleagues identi...Saliva spits out information on chemical exposure
... pesticides we are studying, organophosphates, are chemically similar and work on the same general principal as nerve gas," said Charles Timchalk, a Battelle toxicologist at PNNL. "Both pesticides and nerve gases inhibit an enzyme called acetylcholinesterase. Without acetylcholinesterase, nerves, including thos...White House awards National Medal of Science to Rockefeller University's James Darnell
...in formation, showed that both these molecules are chemically "processed" -- chemical groups are added after synthesis and a long initial product is cut into usable pieces -- before their use in the cell's cytoplasm, the component of the cell that surrounds the nucleus containing the cell's DNA code. His studie...NIH told regular and moderate exposure to sunlight is the key to preventing chronic disease
...d identified the active form of vitamin D but also chemically synthesized this complex molecule and was one of the first to use it for the treatment of renal osteodystrophy. After completing his Ph.D. and M.D. at the University of Wisconsin, he trained in internal medicine at the Massachusetts General Hospital....Envisat observes resurgent ozone hole
...pounds were used by industry was because they were chemically inert they did not react with other materials. Now we have learned to expect surprises, and we monitor accordingly." What was not anticipated was that when these compounds reach a sufficiently high altitude they are split apart by contact with high...New method could aid in prostate and breast cancer diagnosis
...detection. Because proteins, unlike DNA, cannot be chemically duplicated yet, the Northwestern researchers had to develop a method of signaling the presence of a protein. They chose to use DNA as their signal because it can be amplified and read using a number of methods. Using commercially available materials...New chemical process can separate, manipulate carbon nanotubes
...gn and at Rice University have discovered a way to chemically select and separate carbon nanotubes based on thei... diazonium reagent extracts an electric charge and chemically bonds to the nanotubes under certain controlled conditions. By adding a functional group to the end ...Trade Center debris pile was a chemical factory, says new study
...e as metal-rich gases. These then either burned or chemically decomposed into very fine particles capable of penetrating deeply into human lungs. In the trade-center air samples, Cahill identified four classes of particles that have been named by the EPA as likely to harm human health: Fine and very fine tr...Molecule identified that contributes to essential cell functioning process
...echanism. We'd like to figure out how that happens chemically and exactly how this interaction occurs." Along with Marzluff and Dominski, UNC co-authors include Xiao-cui Yang and Handan Kaygun. Co-author Dr. Michael Dadlez is from Warsaw University in Poland.Support for the research came from the National Insti...Dual action anthrax vaccine more effective
...ent has ended. To make the vaccine, the scientists chemically joined two anthrax molecules that are the bacterium's major virulence factors in disease, but in a vaccine act as antigens, stimulating an infected person's immune system to produce disease-fighting antibodies. One is protective antigen, a protein th...First production of a human protein with complex glycosylation in genetically modified yeast
...sses, which can be grown to high cell density in a chemically defined growth medium. This yeast normally produces non-human N-glycans of the high mannose type, which have no therapeutic value for humans. The scientists modified the yeast by first eliminating endogenous yeast glycosylation pathways, while sequen...WSU ecologist says defense by plants to disease may leave them vulnerable to insect attack
...armyworm larvae (Spodoptera exigua). Salicylate is chemically similar to the aspirin that humans take, and it fu...efenses have been either genetically engineered or chemically manipulated. It also illustrates natural constraints on the evolution of plant resistance. A major r...Lone gene could force re-think on pest insect control
...h resistance to a range of commonly available, but chemically unrelated, pesticides. What has baffled and worried the researchers is that the flies are rarely targeted with insecticides and many of the chemicals it is resistant to, it has never been exposed to before. "The fact that a single mutation can conf...Researchers detect receptor for day/night cycles
...e inner retina, that contain melanopsin, a pigment chemically related to other opsins [a type of protein] found in the rods and cones of the outer retina." In their study, the researchers deleted melanopsin from the inner retinal cells of transgenic mice. Mrosovsky found that melanopsin-free mice could not sync......nants. "This (process) is accomplished by laying a chemically reactive mat on top of the ground and around each plant, usually a tree or a shrub, which catches any fallen leaves and twigs," said Adriano. "This allows them to rot, releasing the contaminants in a soluble form, but captured and fixed permanently b...