Cincinnati Children's researchers uncover critical food allergy pathway
...berg. "Since agents that block eotaxin and similar chemokines are being actively developed by a number of pharmaceutical companies, these studies provide impetus for rapidly applying these new drugs to gut allergy." Allergic diseases have reached epidemic proportions, inflicting nearly 30 percent of the populat......ignon and coworkers have studied the expression of chemokines and chemokine receptors in the inflamed airways of...ollowing challenge with inhaled allergens. Several chemokines that bind CCR4 are also induced under these circumstances, suggesting a mechanism by which Th2 cells...UT Southwestern researchers develop new method of delivering vaccines
...is to draining lymph nodes. Small molecules called chemokines attract the trafficking cells and help mediate this process. Lymphatic endothelial cells produce a chemokine known as MIP-3, which binds to a corresponding receptor called CCR7. Langerhans cells utilize CCR7 to migrate from the epidermis to draining ...UC Riverside scientists discover wound-healing substance
...f wounds in chickens. "Both the human and chicken chemokines stimulate a common cell type -- fibroblasts -- to become a slightly different type of cell that has the ability to contract, much like a small muscle," Martins-Green says. "These cells proliferate in the healing tissue of the wound and then pull it ...Discovery sheds light on mechanisms that allow cells to steer directly toward chemical cues
... they need to move directionally. Chemicals called chemokines within the blood or tissues outside the tumor are what attract the metastasizing cancer cells." Information about the steering mechanisms that control the accumulation of white blood cells within the body could also provide medical researchers with n...JCI table of contents, October 21, 2002
... into intestinaltissues, evidence is mounting that chemokines and their receptors may alsobe involved. On pages 1113-1121 William Agace and colleagues demonstratethat expression of the chemokine receptor CCR9 is selectively maintained onCD8+ T cells activated in murine gut-associated lymphoid tissues and thatne...JCI Table of Contents, December 2, 2002
...**** ACCOMPANYING COMMENTARY: Fatal attraction: chemokines and type 1 diabetes CONTACT: Mark A. Atkinson University of Florida College of Medicine Dept. of Pathology, Immunology and Laboratory Medicine ARB-R3-128 1600 SW Archer Road Gainesville, FL 32610-0275 USA Phone: 352-392-0048 Fax: 352-392-8464 E-mai...Curcumin may be an inexpensive, well-tolerated, and effective therapy for inflammatory bowel disease
...factor involved in the production of cytokines and chemokines necessary for inflammation. Regulation of NF- B function has been documented by several agents used in the management of IBD, such as corticosteroids, sulfasalazine, and 5-aminosalicylates (5-ASA). Furthermore, antisense oligonucleotides directed aga...JCI table of contents, January 2, 2004
...e data indicate that proinflammatory cytokines and chemokines induced by viral infection can influence ongoing autoaggressive processes beneficially at the preclinical stage if produced at the correct time, location, and level. Therefore viruses that do not directly destroy beta cells may actually enhance the c...A viral cure for type 1 diabetes
...e data indicate that proinflammatory cytokines and chemokines induced by viral infection can influence ongoing autoaggressive processes beneficially at the preclinical stage if produced at the correct time, location, and level. Therefore viruses that do not directly destroy b cells may actually enhance the cour...Harmless virus helps slow HIV by boosting immune proteins
...t the cells. When the researchers neutralized the chemokines with antibodies, GBV-C had no protective effect. H...ake it persist, so it can continue to induce these chemokines and these changes in the cell that help HIV," said senior investigator Jack Stapleton, MD of VA and ...APS Inflammatory Bowel Diseases Translational Research Conference, Sept. 8-11
...ponses in IBD: Role of the vasculature Cytokines, chemokines and mediators of chronic inflammation Bacterial/host interactions in the pathogenesis of IBD New therapeutic strategies in the treatment of IBD According to co-organizers Matthew Grisham, of Louisiana State University, Shreveport and Fabio Cominel...... palsy. More recently, researchers have found that chemokines also seem to attract stem cells to an injury site....er of cells where they are needed and if the extra chemokines help them become part of a better-functioning brain. He'll try several direct approaches including i...