Scientists report on promising new approaches to induce cancer cell suicide
...s, either as a single agent or in combination with chemotherapeutic agents," said Bharvin Patel, Ph.D., of Eli Lilly, ... currently assessing the activity of LY2181308 and chemotherapeutic agents in the cancer model. Killing cancer cells and endothelial cells with a VEGF-triggered cell de...Scientists discover potential approaches to enhance existing cancer therapies
...s by making tumor cells more vulnerable to certain chemotherapeutic drugs and radiation," says Peter Brooks, Ph.D., associate professor of radiation oncology and cell biology at NYU School of Medicine, who presented the results today. "We will continue to assess the cellular basis for PABA's effects." Although it i...Dietary ginger may work against cancer growth
... compounds may be effective chemopreventive and/or chemotherapeutic agents for colorectal carcinomas," said Bode. Because mice were not allowed to live with tumors bigger than one cubic centimeter, "it's difficult to know if the ginger-treated mice would have lived longer if left to die of their tumors, but it looks ...Cancer prevention pioneer receives AACR/Cancer Research and Prevention Foundation Award
...g people with a combination of chemopreventive and chemotherapeutic agents. He achieved dramatic results by augmenting vitamin A derivatives with two biological agents a-tocopherol and interferon-a especially in people with advanced lesions of the throat. Furthermore, the combination appears to be effective in re...Clinical study reports findings of combination therapy with DOXIL
...ted to physicians experienced in the use of cancer chemotherapeutic agents. Availability DOXIL is available only by prescription and administered by a health care professional. It is marketed as DOXIL in the U.S. by Ortho Biotech Products, L.P. and in Israel by Janssen-Cilag. It is marketed as CAELYX elsewhere by ...The mechanics of anti-tumor activity outlined
...ent HIF inhibitor of all the microtubule-targeting chemotherapeutic agents tested that are used to treat cancer." The paper outlines the mechanism by which 2ME2 downregulates HIF; a finding that had not been previously discovered. Utilizing a pharmacological approach and xenograft models, which are mouse models of...Study suggests ovarian cancer cells can alter surroundings to promote chemotherapy resistance
...eir microenvironment so they are more resistant to chemotherapeutic drugs commonly used to treat the disease, according to investigators at the National Institute on Aging (NIA) Intramural Research Program and colleagues at other research centers. "It has been known for some time that the microenvironment of cancer ...Researchers develop first mouse model of epithelial ovarian cancer
...es to advanced disease. "The next step is to test chemotherapeutic and chemopreventive agents that we hope will translate into meaningful improvements in the prevention and treatment of ovarian cancer. We'll also study the relevant oncogenes and tumor-suppressor genes for their ability to allow or trigger the cance...UNC studies target molecular defects implicated in cancer, genetic diseases
...ated with increased resistance of these cancers to chemotherapeutic agents. In the new study, antisense molecules were...were able to sensitize these cell lines to various chemotherapeutic agents and radiation. "Our gene-based therapy would presumably be specific for cancer cells, which o...Researchers developing technology to outsmart metastasized cancers
...e attached to folate molecules. As a result, these chemotherapeutic agents can be delivered more specifically to cancer cells while leaving the surrounding normal tissue unharmed. One form of this "Trojan Horse" therapeutic approach (folate-targeted immunotherapy) was used by a joint Purdue-Endocyte research team to ...Gemcitabine demonstrates promise as a low toxic chemotherapeutic agent for bladder cancer
...enefit from treatment with gemcitabine (Gemzar), a chemotherapeutic agent that has been used successfully to treat pancreatic cancer and non-small cell lung cancer, according to phase I trial results reported at the 38th Annual Meeting of the American Society for Clinical Oncology (ASCO). The study, presented by Mer...Chemgenex reports use of chemical genomics strategies to advance drug development
...n that was unique compared to that produced by the chemotherapeutic drug Taxol(TM), which is known to be a potent angiogenesis inhibitor. Ceflatonin(TM) treatment resulted in a dramatic reduction in angiogenesis, with only a few fine vessels forming. In contrast, Taxol(TM) treatment resulted in more vessel formation,...Cell Pathways CP461 demonstrates multiple anti-cancer activities
...ected Taxotere (docetaxel), the currently approved chemotherapeutic for advanced non-small cell lung cancer (NSCLC). ...ization properties like some types of conventional chemotherapeutic agents, but instead disrupts microtubule organization and proper spindle formation cellular structu...Hammering cancer cell survivin
... in a similar manner, probably in conjunction with chemotherapeutic or immunotherapeutic agents, to control human tumors in a clinical setting....New bacteria target cancers in mice
...injected spores of these bacteria and conventional chemotherapeutic agents into mice with large tumors composed of transplanted human colon cancer cells. The results achieved with this strategy, called COBALT for combination bacteriolytic therapy were dramatic. More than half of the tumors treated, including very l...Highly specific biological agents attack mechanisms of treatment resistance
...inuous infusion of the Genasense combined with the chemotherapeutic drugs fludarabine, cytarabine, and filgrastim. ... because it is intended to be used in concert with chemotherapeutic drugs, rather than as a cancer treatment in its own right.......ients would take in conjunction with antibiotic or chemotherapeutic agents to keep those drugs in the cells and increase their efficacy." MsbA transports lipid A, a component of bacterial cell walls, from the inner to the outer membrane of bacteria and is necessary for bacterial cell growth. It belongs to the ATP Bi...New model of staph drug resistance implicates unlikely protein
...chanisms to beat the potentially lethal effects of chemotherapeutic agents. Of these bacterial tricks, the most important was the acquisition of a foreign gene - the mecA gene - that confers resistance to methicillin in addition to penicillin and a host of other antibiotics, all belonging to what scientists refer to ...Blood vessels found to signal chain of destruction in bone diseases
...l disease or cancer. Current anti-inflammatory or chemotherapeutic treatments are inadequate for this purpose. However, OPG injection prevents such bone and cartilage loss, without interfering with normal bone remodeling. More significantly, the discovery that blood vessel cells themselves are initiators of t......certain forms of radiation and chemotherapy." Most chemotherapeutic agents work by selectively killing actively dividing cells, meaning that many quiescent, or non-dividing, tumor cells are immune to treatment. Suspended animation also has a role in the growth of normal cells, Roth said. "Stem cells - like those tha...