Protective protein caps discovered at ends of human chromosomes
... altered its ability to bind DNA might provide new chemotherapeutic agents," he said. In addition, telomere replication in the laboratory can allow for continuous proliferation, or "immortality" of human cells, so the POT-1 protein could have implications for the aging process. "Only time will tell," said Baumann....Drug resistance found to vary by ethnicity
... cells of drugs. When working correctly, PGP pumps chemotherapeutic drugs out of tumors, allowing the tumor cells to survive. This response is known as drug resistance. The genetic mutation means the PGP pump stops working, allowing drugs to enter and kill tumor cells. PGP also rids cells of many other medications, ...JAK-STAT signaling keeps leukemia cells alive
...ulated by STAT3. The work reinforces the view that chemotherapeutic agents inhibiting the JAK-STAT pathway might prove of considerable utility in treating LGL leukemia and perhaps other neoplasms....... number of chromosomes respond very differently to chemotherapeutic drugs than do cells with a normal number. Aneuploi...loped resistance. Thus, aneuploid cells respond to chemotherapeutic drugs just like cancer cells. The researchers concluded that continuous chromosome reassortment faci...... both a single agent and in combination with other chemotherapeutic agents. Millennium is committed to initiating add...hase I trials of LDP-341 in combination with other chemotherapeutic agents are planned as well as Phase II studies. The first combination study, LDP-341 with 5-FU and ...Treatment protects mouse ovaries from radiation therapy
...protection would be afforded to ovaries exposed to chemotherapeutic drugs. "For the first time we have a promising prospect for a small molecule that could be given to women and girls undergoing cancer treatment to protect their ovaries," says Jonathan Tilly, PhD, the paper's senior author. However, he notes that fu...Researchers determine improved pattern for artificial light-harvesting molecule
...super-efficient photoelectric cell or to release a chemotherapeutic drug inside a tumor after it's been carried through the bloodstream. Dendrimers might even one day act as the initial necessary step in photosynthesis, improving the light-harvesting task performed naturally within any green leaf, to yield crops that...New mechanism of drug resistance found in cancer cells
... more sensitive to traditional chemotherapeutic drugs," said Jessie L-S Au, Distinguished ... more sensitive to traditional chemotherapeutic drugs, and plan to test this new therapeutic approach in patients," said Au. ......a single agent and in combination with traditional chemotherapeutic agents against such cancers and precancerous conditions as prostate, breast and lung cancer, sporadic colon polyps (a precursor to colon cancer), and Barrett's esophagus (a precursor to esophageal cancer). Cell Pathways is also conducting Phase IB sa...Targeted Genetics presents clinical data on E1A cancer gene therapy
... to suppress metastases, increase sensitization to chemotherapeutic agents, increase sensitization to radiation, induc...d tumor formation and metastasis and resistance to chemotherapeutic agents.......gle agent cancer therapy and in combination cancer chemotherapeutic studies in the near future." CP461 is a secon... side effects normally associated with traditional chemotherapeutic agents. SAANDs also do not inhibit cyclooxygenase (COX I or COX II) and have not exhibited the gastr......fects to normal cells associated with conventional chemotherapeutic drugs. "Poster presentations by company scien... side effects normally associated with traditional chemotherapeutic agents. They also do not inhibit cyclooxygenase (COX I or COX II) and have not exhibited the gastric...Targeted Genetics presents advances in systemic gene delivery technology
...herapy indicate that E1A sensitizes tumor cells to chemotherapeutic agents . Targeted Genetics is evaluating tgDCC-E1A...d tumor formation and metastasis and resistance to chemotherapeutic agents. Targeted Genetics is currently testing E1A in Phase II trials in patients with head and nec...Exisulind (Aptosyn™) and other SAANDs compounds halt prostate cancer cell growth by two mechanisms
... side effects normally associated with traditional chemotherapeutic agents. They also do not inhibit cyclooxygenase (COX I or COX II) and have not exhibited the gastric and renal toxicities reported to be associated with non-steroidal anti-inflammatory drugs (NSAIDs), including the COX II specific inhibitors. A New D...Learning how cell's tiny motor powers its mobility
...g, such inhibitors might have application ascancer chemotherapeutic agents. "Also, there is some indication that certain neurodegenerative diseases might result fromkinesin-related deficiencies in transport. In such cases, a therapy that stimulates the transportsystem might be effective in treatment."...Targeted Genetics presents advances in synthetic gene delivery technologies
...cer product, to sensitize tumor cells to standard chemotherapeutic agents. Additionally, Dr. Anklesaria will present...the potential to sensitize tumor cells to standard chemotherapeutic agents," said Dr. Anklesaria. "Moreover, tgDCC-E1A elicits a response in cells over-expressing HER...UB establishes institute for research on lasers, photonics and biophotonics
...electively destroyscancer cells without the use of chemotherapeutic agents. "The entire purpose of this is to take the therapy inside the cancer cell," said E. J. Bergey, Ph.D., research associateprofessor of chemistry at UB. "The advantage of the nanoclinic concept is that we can target specific cancers and effect...Hutchinson Center to lead $11.5 million ovarian-cancer research consortium
...to identify the genes that influence resistance to chemotherapeutic agentssuch as cisplatin. Such genes would be targets for treatment strategies aimed atbreaking down chemotherapy resistance. If this work leads to breakthroughs inthe understanding of chemoresistance, and ways to improve treatment areidentified as a ...Scientists clear hurdle in effort to destroy experimental brain cancers with viruses
...--Teaming tumor-attacking viruses with an approved chemotherapeutic drug may be more effective thaneither agent alone for treating multi-site brain cancers, reports a team of Massachusetts General Hospital and Harvard MedicalSchool researchers. The findings may advance efforts to treat difficult brain cancers and may...