Tag: "chromosome" at biology news

Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs

...untwisted to enable gene transcription and chromosome replication. Scientists have known since the 1970s that this biological feat--akin to the familiar magic trick of unlinking two interlocked metal rings--is accomplished by a family of enzymes called topoisomerases. ...

Second Breast Cancer Gene Located

...es, they were able to track the gene to a regionon chromosome 13. A recent finding of a pancreatic cancer with a deletionof genetic material in the precise region of BRCA2 also aided in localizingthe region where the gene resides, Futreal said. The inherited mutations appear to damage the cell's abili...

Duke Researchers Find Second Gene Linked To Blood Vessel Disorder

...linked to HHT. This gene, called ENG,is located on chromosome 9 and encodes a protein called endoglin, whichalso appears to bind TGF-_. He hypothesizes that both ALK1 and endoglin are TGF-_ receptors specificto the cells lining the blood vessels. They might only be needed if thevessel is injured and needs to...

International Research Team Clones New Skin Cancer Gene

...s. In 1992, Bale mapped the NBCCS gene to human chromosome 9, and over the past 4 years he and his collaborators sorted through 40 genes from this region. In May, Bale's group reported isolation of PTC, a human gene similar to a previously reported fruit fly gene. "Nobody had a clue that this gene had anyth...

Newly Discovered Gene Halts Cell Division and May Have Cancer Link

...ructures, called centromeres, that fit around each chromosome like a napkin ring. In order for a cell to divide,...uces a protein that sits at the centromere of each chromosome and waits for the thread-like fibers to attach. If the fibers attach properly, cell division proceed...

Two Long-sought Diabetes Gene Found

... disorder to mutations of two similar genes one on chromosome 12 and one on chromosome 20 that regulate the activity of other genes. "Both of these are known genes but neither one was co...

ORNL Finds Common Genetic Cause For Epilepsy, Migraine

...ch theyisolated, mapped and studied effects of the chromosome 8 Cacnl1a4 gene foundin mutant "tottering" mice, w...on of the mouse gene has a counterpartin humans (a chromosome 19 region) that had previously been identified ascausing episodic ataxia (spells of incoordination) ...

The CIA Would Like To Know What Scientists Are Seeing Over The Rainbow

...t waves into a full-color palette and assigns each chromosome its own distinct hue. With all 23 pairs of human ...xtremely valuable in diagnosis of disease based on chromosome alterations. "The value of chromosome examination in understanding the changes that take place duri...

NIH Team Discovers Endocrine Tumor Gene

...ue for loss of a segment of the normal copy of the chromosome a patient would have inherited from an unaffected ...gan the arduous task of cloning and sequencing the chromosome region. Over a two and a half year period, the NHGRI researchers identified 18 new genetic markers ...

Researchers Find Production Point Of Key Protein In Fragile X Syndrome

...Fragile X"refers to the broken appearance of the X chromosome -- half the chromosomepair that determines sex -- ...tion to slightly below normal intelligence. The X chromosome contains many genes. The fragile X gene contains thecode for the fragile X mental retardation protei...

Second Gene Responsible For Tuberous Sclerosis Complex Identified

... of Health. Investigators located the TSC1 gene on chromosome 9. The gene makes a proteincalled hamartin, named...h codes for a proteincalled tuberin, is located on chromosome 16 and was identified in 1993 by aEuropean consortium of investigators. Both the TSC1 and TSC2 gen...

Huntington's Disease Findings Pave Way For Potential Cure

...lness. The cause is a mutation ina gene located on chromosome 4: Instead of having molecule groups that repeat asmall number of times, they repeat 40 or more times and produce a defective formof the huntingtin protein. The defective protein interacts with brain cells,though exactly how has not been known. ...

New Gene May Intensify Breast Cancer Growth

...d in breastcancer-1), by searching the long arm of chromosome 20 for genes whose expressionand copy number are elevated in breast cancer. The gene is expressed at lowerlevels in normal human tissue. AIB1 is the most recently identified member of agene family known as SRC-1 (steroid receptor coactivator), all of...

Research Team Discovers Key Gene For Telomerase Enzyme In Humans

...cts telomere shortening by addingDNA back onto the chromosome ends, he said. Normal cells do not containtelomerase, and their telomeres shorten with each cell division until theystop dividing. In cancer cells, however, telomerase is thought to grantthe cell immortality by maintaining telomere length so that t...

Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes

...chromosomes is damaged [beyond repair] or the Y chromosome provides protection," he said. "At the moment we favor the 'excessive X chromosome damage' argument since both MSH2 and p53 are involved in managing DNA repair." Colleagues a...

MGH-Led Team Finds Gene For Crippling Neurologic Disorder

...pointing the location of the gene, called DYT1, on chromosome 9 and their discovery that virtually all cases of ...r for the gene, which localized it to a segment of chromosome 9. While the MGH researchers worked out the genetic and molecular aspects of this discovery, their ...

Gene For Last Major Form Of Batten Disease Discovered

...ly complete sequence for the gene and mapped it to chromosome 11. This is the first time researchers have used the mannose-6-phosphate strategy toidentify a defective gene. For LINCL, this strategy proved faster than thecommon approach, called positional cloning, which is used to identify which ofthe body?s 10...

Gene Locus Found For Essential Tremor Disorder

...eport how they traced the gene to the short arm of chromosome 2 (1). "This is an important advance for a disord...inda E. "A gene (ETM) foressential tremor maps to chromosome 2p22-p25." Movement Disorders, Vol. 12(6),1997, pp. 859-864....

Colorado State Scientists Tackle Genetic Makeup Of Obscure Bacteria

...ng disease," Inamine said. "There are piecesof the chromosome missing from each of the strains, but in different regions. Wethink this could provide some key clues as to where to look to find the genesthat produce the bacteria that cause disease and the bacteria that don't." Once these genes have been i...

Autoimmunity Gene Discovered

... and in 1994 the disease locus was localized to chromosome 21q22.3 by Pr Leena Peltonen's group from the National Public Health Institute (Helsinki, Finland). After that publication, Pr Peltonen's group teamed up with Dr Marie-Laure Yaspo and her group from Max Planck Institute for Molecular Gene...

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