Tag: "chromosome" at biology news
Scientists Identify A Novel Mitotic Regulatory Mechanism
...acterized by defined periods of preparation for chromosome
replication (G1), DNA replication (S), preparation for mitosis (G2), and mitosis (M). Proper transition between these states require an evolutionarily highly conserved set of proline directed protein kinases. The overall principle underly...
Peutz-Jeghers Disease Gene Identified: Enzyme Loss Causes Polyps And Cancer
...ctor was located on the tip of the short arm of chromosome
19. Affected individuals in several different f... of Helsinki, who had identified the linkage to chromosome
19p13.3, also found defects in the STK11 gene in 11 out of 12 Peutz-Jeghers families. T...
Doublecortin : A Novel Gene Involved In Cortical Development
... transmission of genetic markerslocated on the sex chromosome
X in members of three families in which girls hadSCLH and boys had lissencephaly. This genetic mapping approach by linkageanalysis allowed them to confirm that the defective gene responsible for thecortical malformations is located on the X chromosom...
Harvard Medical School Researchers Present Atomic Structure Of DNA-Replicating Enzyme Widely Used In DNA Sequencing
...cell division and faithfully replicates the entire chromosome
at a rateof up to 400 building blocks--or nucleotides--per second. To do that, it needs thehelp of a second protein (shown in orange) to stay clamped to the DNA. This work shows in exquisite detail how the polymerase recognizes the rightnucleotide to...
Telomeres and Telomerase
...CHERN, J. PRESCOTT and T. WARE Telomerase and the chromosome
end replication problem T. R. CECH and J. LINGNER Characterization of the role of the EST genes in yeast telomerase function T. HUGHES, D. MORRIS, N. WALCOTT, C. NUGENT, A. SALINGER andV. LUNDBLAD Drosophila telomere elongation H. BIESSMANN, M. ...
Gene For Inherited Syndrome Is Possible New Tumor Suppressor
...ene causes it. So you map the gene's location on a chromosome
and clone it, and then you find out what it does. ...(more specifically, to the tip of the short arm of chromosome
19). With the gene identified, further study revealed a number of mutations thatdisabled it. A gene...
Technique Gives Researchers New Look At Genetic Activity In Living Cells
...asier to see, and likely willlead to insights into chromosome
movements, folding and unfolding duringnatural eve...d like to learn what happens to the structure of a chromosome
when a gene is turned onor off." The method uses a specific protein-DNA interaction in which a prot...
Study Finds Gene Is Associated With Higher Risk Of One Kind of Stroke Among African-Americans
...culation and Stroke. The gene, located on chromosome
19, is the blueprint for the productionof apolipoprotein-E (apo-E), a protein that is responsible for transport anddisposal of cholesterol within the central nervous system. The researchersfocused on one of the gene's three known variants, or allele...
Genetics Of Obesity And Of The Response To Chronic Overfeeding
...dence for linkage with bodyfat was with markers on chromosome
11q21-q22, 6p21.3 and 3p24.2-p22, while inthe latter it was with markers on 2p21. Evidence for linkage with markers on7q33 was obtained in all family studies with the only apparent exception beingthe Pima Indians. Our own results from the Quebec ...
Hormone Control Of Rare Leukemia Sheds Light On Molecular Basis Of Cancer
...fusion protein is a product of a genecalled PML on chromosome
15 and the gene for the retinoic acid receptor (RAR) onchromosome 17. In another 4 percent of the cases, the protein is a fusionbetween the RAR and a gene for a protein of unknown function called PLZF. "The involvement of the retinoic ac...
Researchers Closing In On Gene For Paralytic Disorder
...myotrophic lateral sclerosis (ALS), to a sectionof chromosome
9. "These results bring us a major step c... samples. Two genes already identified on chromosome
9 are potential suspects,according to Phillip Chance, M.D., formerly of Children's Hospital ofPhilad...
Rare Mutation Find May Offer Clues To Treating Osteoporosis
...- building blocks ofproteins -- were missing from chromosome
17. Those without the kinky hair andwith good teeth showed no missing nucleotides. Hart, a dentist and medical geneticist, called the discovery "quiteexciting scientifically," partly because it is the first mutation of its ki...
Mouse Gene Reveals Clues To Human Deafness
...the defective gene, namedDFNA15. It was located on chromosome
5 near another gene for inherited deafnessidentified by King and Lynch in an extended Costa Rican family only a few monthsearlier (reported in the Nov. 14, 1997 issue of Science). Avraham contacted theUW geneticists, and the groups began working toge...
Chromosomal Abnormalities Key For Prediting Leukemia Outcome
...d a loss of, or damage to, one of thetwo copies of chromosome
5 or 7 had a median survival of 3 months, whilethose showing damage to chromosome
16 had a median survival of 18 months. Of the 628 AML patients in the study, 56 (9 percent) we...
'Mean Gene' Found In Africanized Honey Bees
... gene for further study. "We've found a place on a chromosome
where this gene or genes may be, but we hope in time to be able to localize it better," Page says. "Someday we may actually be able to isolate and characterize the gene and find out how the two versions of the gene differ." Hunt says the finding will...
Novel Method Of Gene Replacement Reported By University Of Washington Researchers
...eting the exact location of the mutated geneon the chromosome
and replacing it with the correct genetic material present inthe viral vector, at exactly the right location. Russell uses a typewriter analogy: the new method finds thetypographical error, whites it out and types in the proper sequence in t...
Jefferson Scientists Link Some Cases Of Scleroderma To Damage From Lingering Fetal Cells
...blood of 32, or 46 percent, of the women. The Y chromosome
DNA was present in only one of 25 normal women. The scientists also found Y chromosome
sequences in skin biopsies in 11 of 19, or 58 percent, of the women tested. Nine of the 11 women ...
Electron Accelerator Provides Unique Proof Of Gene Repair Process In Living Cells
...to prove: within the seven-some-feet of the folded chromosome
in every cell nucleus, special repair proteins do ... the April 24 Science. "In the past 24 hours, each chromosome
in each cell of our bodies has been damaged by cancer-causing chemicals, ultraviolet radiation or fr...
Reports Mesh To Clarify Proteins' Importance For Cancer
...eryday life, cells experience a moderate degree of chromosome
damagethrough exposure to environmental chemicals, radiation and the naturalbyproducts of normal cellular processes. Cells constantly monitor thechromosomes, activating DNA repair systems to fix the damage once it's detected. DNA repair systems are a...
Researchers Identify A Gene That Causes Juvenile Polyposis
...making available good markers to help determinethe chromosome
where genes are located. The group was able to identify thechromosome using linkage studies a year after beginning the project. The gene,SMAD4/DPC4, was originally identified and mapped in 1996 by researchers at JohnsHopkins University. Deletions of ...
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