Tag: "chromosome" at biology news
Researchers Identify And Isolate First Gene For A Form Of Insulin-Dependent Diabetes
...theinvestigators found that mutations in a gene on chromosome
4 cause a disordercalled Wolfram Syndrome. The disorder is characterized by insulin-dependentdiabetes and vision problems, with eventual blindness. The syndrome also caninclude diabetes insipidus, a pituitary gland disorder associated with intensethi...
Hopkins And International Team Maps First Major Cancer Gene To X Chromosome
...tterncharacterizes genetic traits carried on the X chromosome
and passed from mothersto sons, such as muscular d...er, the researchers found a specific area on the X chromosome
that wasshared more frequently than one would predict as determined by statisticalanalysis. That ar...
Genetically Speaking, Race Doesn't Exist In Humans
...NA, a form inherited onlyfrom the maternal side; Y chromosome
DNA, paternally inherited DNA; and nuclearDNA, inherited from both sexes. His results showed that 85 percent of geneticvariation in the human DNA was due to individual variation. A mere 15 percentcould be traced to what could be interpreted as "rac...
Study Finds First Genetic Clues To Brain Tumor Treatment
...of oligodendrogliomas: loss of part of one copy of chromosome
1,loss of part of one copy of chromosome
19 and deletion of a portion ofchromosome 9. Some tumors show only one change while others show com...
Researchers Discover Tumor-Supressor Gene That May Indicate Susceptibility ToLung And Colon Cancer
...nning of a tumor. The researchers found PPP2R1B on chromosome
11 in an area they call a "hot spot"for cancer gen... the area because in many tumors asmall section of chromosome
or a gene is missing. This is called loss ofheterozygosity (LOH). Using a computer and gene sequence...
...unction, is associated with the cystatin B gene on chromosome
21. Although the role of cystatin B in the pathophysiology of epilepsy has been amystery, mouse models have shed some light on this curious connection. Micethat are deficient in cystatin B show the same symptoms of epilepsy as humansand have profoun...
Tau Gene Linked To Family Of Neurodegenerative Disorders; Finding May Yield Insight Into Onset Of Alzheimer's Disease
..."frontotemporal dementia andparkinsonism linked to chromosome
17." The diseases vary in the symptoms they cause--frontotemporal dementia, forinstance, prompts patients to withdraw socially and to become disinhibited asthey lose their cognitive abilities, and pallido-ponto-nigral degenerationmanifests itself as ...
New Form Of Inherited Dwarfism In Large Pakistani Family Caused By Genetic Mutation In A Pituitary Receptor
...ecessive manner; i.e., the mutated gene, locatedon chromosome
7, must be carried by both parents for the disorder to manifest.Those who had only one copy of the gene (heterozygous) had mild biochemicalGHRH-R abnormalities but only minimal or no growth retardation. Four of the affected males in the group...
Sick Kids Improves Access To Global Genome Database
... servicesas DNA sequencing and synthesis, gene and chromosome
mapping, geneidentification, and bioinformatics. The Hospital for Sick Children Genome Database can be found at: gdb.sickkids.on.ca For further information contact Liz.Leake@sickkids.on.ca or call (416) 813-5046....
Genetic Code Of Chromosome Of Malaria Parasite Deciphered
... has determined the complete genetic sequence of a chromosome
ofthe most deadly malaria parasite, Plasmodium fal...Gardner, Hoffman and their collaborators sequenced chromosome
2 of P.falciparum. Theirs is the first report to describe the complete geneticsequence of a parasit...
Counting X Chromosomes To Determine Sex
...ize their own eggs in the absence of males. The X chromosome
in C. elegans, says Meyer, "has at least fourgenes, probably five or six," that signal the chromosome's presence Allthose X signals are believed to dampen the activity of a pivotal protein, calledXOL-1, that processes the incoming X signals and ste...
When One Gene Has Two Roles, Its Second Function May Be Missed
...tsit in the normal chromosome. When the artificial chromosome
was injected intomouse embryos that lacked GATA-2, blood cell formation was restored, or"rescued," and live mice were born. Surprisingly, however, despite a normal blood forming system, all the mice diedshortly after birth. Post-mortem examination re...
Scientists Finger A Molecular Kingpin In Body's Response To Cigarettes
...gle type of tissue. Specifically, theteam measured chromosome
breaks in blood cells created in the bonemarrow. The team plans to study damage in other tissues, such asthe liver and lungs. Gasiewicz also says that longer-term studiesto look for some of the ultimate products of damaged genes --tumors -- are neces...
Molecular Basis Of Leading Genetic Cause Of Infant Death Discovered
...fects in the Survivalof Motor Neuron (SMN) gene on chromosome
5. Spinal muscle atrophy is aninherited condition that affects about one in 6,000. "Our work describes the function of the SMN protein and links it tospinal muscle atrophy, opening up the possibility to search for therapeutics,"reports Gideo...
Disease Mechanism In Hereditary Dementia Discovered: Treatment Implications Seen For Alzheimer's And Other Neurodegenerative Diseases
...a linked to more than 10different genetic flaws on chromosome
17 known as frontotemporal dementia andparkinsonism (FTDP-17). They found that, in FTDP-17, mutant versions of aprotein called tau are unable to fulfill one of the protein's crucial roles,which is to stabilize structural elements in neurons called mi...
National Science Medalists Named
...rk on cancer and aging, Rowley for her research in chromosome
abnormalities that opened new areas of study in di...n the relationship of prior treatment to recurring chromosome
abnormalities. (Media Contacts: Bill Noxon, NSF, and John Easton, University of Chicago, 773-702-62...
International Genome Team Deciphers Genetic Instructions For A Complete Animal
...n'tencode proteins but probably plays some role in chromosome
function ororganizing genes or regulating their activity. For almost a decade, teams on both sides of the Atlantic snipped and sequencedmillions of bits of worm DNA, pasted it into long stretches of documentedsequence, and dumped it into a public dat...
Gene Identified For Heart Defect That Causes Sudden Death In Young People
... the American Heart Association.The gene, found on chromosome
3, is responsible for a heart condition calledarrh...d the mutant gene that causes ARVD in the familyto chromosome
3. ARVD strikes about 1 in 5,000 people and accounts for about 15 percent of suddendeaths in young p...
Jackson Laboratory Researchers Identify Neuromuscular Degeneration Gene
... gene involved in SMA has been identified to human chromosome
5q. The Neuron paper reports that the defe...e, known asSmbp2, encodes a DNA-binding protein on chromosome
19. Although this protein hasbeen studied previously by different laboratories as SMBP2 (immunoglobu...
Immortalizing Enzyme Does Not Make Human Cells Cancerous
...aracteristics associated with cancercells, such as chromosome
instability, serum-independent growth, loss of contactinhibition and loss of cell-cycle checkpoint controls. In an accompanyingarticle, collaborators at the Geron Corporation and academic colleaguesdemonstrate that the cells with introduced telomeras...
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