Tag: "chromosome" at biology news
Scientists link gene to uterine dysfunction
...because it binds specifically to the centromere, a chromosome
region essential for proper cell division. When scientists bred mutant mice that lack CENP-B, however, the mice appeared surprisingly normal. To take a closer look, Choo and colleagues have now mutated the protein in three genetically distinct mous...
Why muscle strength seeps away: a new cause for muscular dystrophy
...nd to localize the genetic defect in a new area on chromosome
17. Because of the small number of informative fam...landmarks and milestones for this large portion of chromosome
17 last work. This work opened him the way to identify and assemble most of the genes from this regi...
University of Pittsburgh researchers uncover mitochondrial defect involved with inherited cancers
...ment of psychiatry, found that a defective gene on chromosome
11q23, a region previously implicated in the progression of many solid cancerous tumors, causes a hereditary tumor called hereditary paraganglioma. Paraganglioma tumors most commonly occur in the carotid body, a small organ located in the carotid ar...
Isolated Barbados population helps researchers zero in on asthma and allergic disease genes
... asthma. The researchers report that one region on chromosome
12q and two on 17q appear to contain collaborating genes that control risk of increased levels of IgE, antibodies produced by the immune system that cause allergic reactions. Although the precise genes on chromosomes 12 and 17 are not known at this t...
Progress in mental retardation research
...ific MR, including a variety of mutations on the X chromosome
that mostly affect males. Because sufferers with ... MR, among an estimated 20-100 such genes on the X chromosome
and possibly hundreds altogether on the human genome. Interestingly, most of the identified genes p...
Genome scientists muster computer software tools for handling the flood of raw data from the Human Genome Project and related efforts
... not provide a continuous DNA sequence across each chromosome
-- many regions of the genome are covered only by small pieces," he said. The first task Haussler and the Whitehead group are tackling is to line up all of the segments of the human genome sequenced so far in their proper order and orientations al...
UMass microbiologist's Nature article contributes to understanding of how cells divide
...nctions of DNA recombination, repair, replication, chromosome
segregation, and cell division were thought to be ...at mutations in this simple organism with a single chromosome
to see how these mutations affected the ability to restart replication. They knew that special sets...
New technique improves accuracy of gene tests
... comes from the father. Thus, there is a chromosome
3, for example, from the fathe... Furthermore, every gene on the paternal chromosome
3 has a counterpart on the maternal chromosome
3. In some g...
Intersex goats link to rare human disorder
... markers, or unique sequences, spaced out over the chromosome
area harboring PIS. For each marker, they also identified several variations, or alleles. They then examined hundreds of goats to see whether particular alleles were strongly associated with hornlessness, thus identifying the genetic markers neares...
Scientists clarify much-sought enzyme, pave road to cancer therapy
...se areas, called telomeres, act as caps,protecting chromosome
ends either from being degraded or from abnormally...ist wrote inan earlier Cell article, the resulting chromosome
instability would "wreakhavoc on the genome." Scientists have found that normal and cancer cells dif...
Bitter taste receptors identified
...focused on a specific interval of DNA on one human chromosome
that was known to be associated with the ability t...ve pinpointed a cluster of gene positions on mouse chromosome
six that are associated with the tasting of a number of bitter substances. When Zuker's and Ryba's g...
Discovery of taste receptors may make bitter a bygone taste
... bitter receptors by focusing on a region of human chromosome
5 that was known to affect the ability of certain individuals to detect a bitter compound. They found a gene that coded for a protein of the right size and shape to be a taste receptor. From there they discovered many closely related genes clustered...
UC Berkeley biologist disputes current dogma that genetic mutation is the cause of cancer
...berg and found that all of them also had numerical chromosome
alterations, or aneuploidy. "The cause could have ...tion caused by having too many copies of an entire chromosome
is much greater than that expected from a handful of mutated genes, and is much more likely to affec...
Researchers decode human chromosomes 5, 16, and 19
...of the human genome. Disease-linked genes on this chromosome
include those for colorectal cancer, basal cell ca...man genome. Studies have implicated genes on this chromosome
in the development of breast and prostate cancer, Crohn's disease and adult polycystic kidney diseas...
Northwestern team identifies first enzyme in mammalian circadian clock
...cate the tau mutation to a position on the hamster chromosome
that coincides with the CKIe gene. Their analysis ...ysis further showed that the region on the hamster chromosome
with the CKIe gene is similar to regions on human chromosome
22 and mouse chromosome
15. "This ...
Nearly identical controls of immune genes in mice and humans hint at new asthma treatment
...urnal of Immunology, the scientists inserted human chromosome
segment 5q31which contains the genes for the three human interleukins (Ils) into the chromosome
of a mouse that includes that species' versions of these genes. "Remarkably," they report, "these ...
Cloning reverses aging in cow cells, a milestone in medical research
...sidered to be the strand of DNA at the end of each chromosome
(called telomeres), and is shortened every time a cell divides. When the aging clock runs out, the cells stop dividing. Medical science has long sought to discover a "Fountain of Youth" that could potentially turn back the aging clock to return old c...
Cloning reverses aging in cow cells, Scienceauthors say
...ir chromosomes. Telomeres cap off the ends of each chromosome
and keep their genetic threads from fraying and disappearing with each tug that happens when the cell divides itself again. Since most mammalian telomeres can't repair themselves, they are usually slowly worn away over time--shorter telomeres are oft...
Gene tug-of-war leads to distinct species
...ybrids was partly due to two genes -- one on the X chromosome
of the polionotus species that is expressed only ...ted from the mother, and the other on an autosomal chromosome
of the maniculatus species that is expressed only when inherited from the father. The scientists lo...
The German-Japanese Consortium deciphers human chromosome 21 - A basis for comprehensive understanding of trisomy 21 (Down syndrome)
...es (also known as Down syndrome). An extra copy of chromosome
21 results in severely aberrant physical and menta...d Japanese scientists will publish the sequence of chromosome
21 in the journal Nature (18th May 2,000). This work will be freely available on the Nature website ...
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