$1.86 billion boost for UK science and innovation
...gth of science and innovation in the UK is a world class and financially robust research base with growth in public and private investment. The framework has been developed with stakeholders in the research base and the private sector, including The Wellcome Trust which expects to commit at least $2.8 bill...UCSD biologists discover cell's defense mechanism against class of disease-causing bacterial toxins
...vered a new mechanism that allows cells to fight a class of toxins made by a wide variety of disease-causin... shown to be important for protecting against this class of bacterial toxin. Aroian and Huffman further discovered that these two genes, SEK1 and KGB1, contr...Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
... technologies and the special characteristics of a class of viruses called adenoviruses to create a series of three vaccines that, when given in sequence, build on each other to generate a stronger immune response than might otherwise be possible. Many current vaccine development programs rely on human ade...Brain serotonin enzyme finding might explain psychiatric disorders
...me might also influence patients' responses to the class of drugs known as selective serotonin re-uptake inhibitors or SSRIs, they added. SSRIs include paroxetine (trade name Paxil), sertraline (trade name Zoloft) and fluoxetine (trade name Prozac). The influence of the serotonin enzyme raises the possibil...OHSU scientists find gene influencing drug withdrawal
...ene, Mpdz, is involved in physical dependence on a class of drugs known as sedative-hypnotics, which are wi...their euphoric and sedative effects. Drugs in this class include alcohol, inhalants, barbiturates, benzodiazepines, like Rohypnol or "roofies," and some othe...Study finds plant enzyme function changes with location in cell
...associate Ingo Heilmann were studying a particular class of enzymes known as desaturases in Arabidopsis, the equivalent of the fruit fly for plant scientists. Desaturases remove hydrogen atoms from fatty acid chains to create carbon-carbon double bonds, desaturating the fat. While using yeast cells to det...Bacteria spill their guts to aid researchers in quest for new antibiotics
...tein MscL is a mechanosensitive channel protein, a class of proteins that detects mechanical force created by changes in tension in a cell's membrane. Changes in membrane tension are brought about when the concentration of the fluid surrounding the cell differs from conditions within the cell. In response ...Hopkins to found first center for comprehensive study of epigenetics
... that Johns Hopkins has pulled together this world class team of researchers to move this important field forward," says NHGRI Director Francis S. Collins, M.D., Ph.D. The ambitious Hopkins center is the ninth grant funded through the NHGRI's and NIMH's Center for Excellence in Genome Science program, and ...Scientist honored for studies of genetic influence on chemotherapy, tumor development
...e AACR-NFCR professorship honors and fosters world class accomplishments among scientists still at a relatively early stage of their careers in basic research, clinical care, therapeutics and prevention. "Dr. Lowe's finding that genetic mutations influence the selection of cancer cells for programmed ...Protein believed to control formation of memory identified by Scripps & UCSD scientists
...wn that when laboratory animals are treated with a class of drugs known as protein synthesis inhibitors, which stops the production of proteins in the animals' brains, these animals lose their long-term memory. This observation has led scientists to predict that the formation of long-term memory requires n...European Commission approves Herceptin + Taxotere as 1st-line therapy in HER2-positive breast cancer
...axol and Taxotere belong to the most commonly used class of chemotherapy agents for metastatic breast cancer in Europe, known as 'taxanes'. This trial with Herceptin and Taxotere firmly establishes Herceptin in combination with taxanes as the foundation of care for women with HER2-positive metastatic breas...Scientists learn how adjuvant makes vaccines effective
...h team was investigating a phenomenon known as MHC class II signaling, which occurs during interactions between B cells and T cells. When properly stimulated, B cells mature into plasma cells, which release antibodies, one of the immune system's major disease-fighting tools. However, researchers had notice...Study finds first evidence COX-2 enzymes can regulate DNA damage
...heir breakdown. This results in the formation of a class of DNA-harming agents called genotoxins, which are known to be involved in the formation of certain human cancers. Interest in the potential use of COX-2 inhibitors as anticancer agents was fueled in part a decade ago when an American Cancer...Volcanic soils yield new clues about the emergence of powerful chiefdoms in Hawaii
...he 18th century. "The Hawaiian Islands had a true class system led by chiefs who enjoyed elite privileges," Kirch noted. "To maintain the social order at the level they were accustomed to, the chiefs had to go into a mode of aggressive action. It's interesting that the really aggressive chiefdoms came fro...Scientists receive awards, give lectures at the ASBMB/IUBMB meeting
...oneered in the discovery of the structures of both class I and class II human major histocompatiblity complex antigens and their recognition of self and foreign peptides...NIH launches first center in Nationwide Chemical Genomics Network
... most marketed drugs are small molecules and this class of chemicals has been the focus of intense screening efforts by the pharmaceutical industry for many years researchers in academia, government and non-profit research institutions traditionally have not been able to tap into large libraries of these...Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy
...ly Type 1 diabetes in mice by restoring a critical class of T cells to their normal balance. The findings, reported in the June 7 issue of the Journal of Experimental Medicine, prove an important biological principle that could lead to prevention of Type 1 diabetes in humans: autoimmunity can be reversed ...CSIRO research in greatest biotech show on earth
..." Dr Hirsch added. "It is important that our world class science leads to commercial outcomes for global benefit". Minister for Industry, Tourism and Resources, The Hon Ian MacFarlane MP, will lead the Australian delegation. The CSIRO delegation of 11 includes senior executives, scientists and business man...U. Iowa muscular dystrophy discovery may lead to new treatment approaches
..., might lead to new treatments for this particular class of muscular dystrophies and other muscle diseases caused by glycosylation defects. A group of muscular dystrophies, which include Fukuyama Congenital Muscular Dystrophy, Walker-Warburg Syndrome and Muscle-Eye-Brain disease, are caused by mutations ......d Medical School researchers have discovered a new class of gene. Most genes carry out their tasks by making a product-a protein or enzyme. This is true of those that provide the body's raw materials, the structural genes, and those that control other genes' activities, the regulatory genes. The new one, f...