Experimental Staph Vaccine Broadly Protective In Animal Studies
...vaccine might be protection against thespectrum of clinically important CoNS." Dr. Pier adds that he and his colleagues hope to move the PNSG vaccine intohuman trials soon, but predicts that such trials are one to two years away. They currently are negotiating licensing rights for the vaccine. Other Ongoing NI...Study points to possible gene therapy cure for hemophilia
... 100 percnet usingAAV gene transfer, they would be clinically beneficial to patients withhemophilia A," Walsh says. He notes that people with severe hemophilia typicallyhave factor VIII blood levels less than 1 percent of normal. "Those patientsstart spontaneous bleeding into joints and muscle and need frequent...Fathers pass infertility to sons
...herited in such cases, that suspicion had not been clinically confirmeduntil now. The finding raises thorny ethical questions about assistedreproduction techniques. "I think this finding is going to change geneticcounseling," said Page, "because what had been a theoretical concern is nowconcrete. Now we have fo...Blocking the binge: UF researchers explore for uncontrolled eating
...purging. Those with binge eatingdisorder are often clinically obese and turn to food in response to what isoccurring in their environment rather than physical hunger cues. An estimated one-third of those seeking treatment for obesity have binge eatingdisorder, according to Dr. Toby Goldsmith a clinical assista...Social behavior transformed with one new gene
...erritories. Discovery of such information could be clinically relevantfor treatment of autism, schizophrenia, Tourette's syndrome and Alzheimer'sdisease, all of which result in isolation and detachment. The study was funded by grants from the National Institute of MentalHealth....Rescuing brain cells in stroke patients from the brink of suicide
...otect brain cellsafter a stroke, they are not used clinically because none has been shown to beboth safe and effective in humans, says Curtis Benesch, M.D., director of theStroke Program at the University's Strong Memorial Hospital. "Right nowtreatment for acute stroke consists of two things: restoring blood fl...Advance may put gene chip technology on scientists' desktops
...tly. Moreover, MAS has the potential to be used to clinically diagnose geneticdisease in humans, and holds great promise for various drug discovery schemes,and the testing of other biological building blocks such as proteins andcarbohydrates. The Wisconsin group has applied for a patent for the new technology t...Why muscle strength seeps away: a new cause for muscular dystrophy
...ics. Muscular dystrophies form a large group of clinically similar diseases characterized by progressive muscle weakness and degeneration. There are many rare forms with various onset, time course, severity and involvement of particular muscles. Some forms appear early in childhood, other forms late in adole......s in those with the HD mutation before they become clinically affected," Ross said. "We saw a large percentage of these patients displaying elevated jerk even when more than seven years remained until symptoms of the disease were predicted to begin." Smith cautions that the results of his study are no...Researchers link genetic defect to 'head-rush' disorder
...in the norepinephrine transporter gene that may be clinically relevant. And of course the norepinephrine transporter has its brothers and sisters in the gene family-like the serotonin and dopamine transporters-that have not yet been genetically linked to clinical disorders but which serve as major targets for ...Pain drug reveals what most already know - men's and women's brains are simply different
...icate kappa-opioidsare more effective in women for clinically significant pain. The original clinical study, led...onses. While Levine's team was restricted to using clinically availabledrugs that could have other effects, the Fields lab was able to use a drug thatacted only a......h those variants respond differently to drugs in a clinically significant way. Geneticist Ira Herskowitz, PhD, professor of biochemistry and biophysics at UCSF and a co-leader of the UCSF project, stresses that a rich range of research expertise is needed to determine how genes control drug response."The excit...Nature's path leads scientists to new antibiotic strategy
...hat may lead to the rational, deliberate design of clinically useful molecules like antibiotics." The design of the new antibacterial agents involved mimicry of naturally-occurring peptides that ward off microbial invasion. Peptides are composed of alpha-amino acids which also are the building blocks of...Bionumerik reports data on two novel supercomputer engineered anticancer agents
...ard doses of cisplatin +/- paclitaxel experiencing clinically significant grade 2 nerve damage (neurotoxicity). This number is substantially less than the expected number of patients with grade 2 nerve damage, based on historical studies of patients who were treated with the same chemotherapy drugs without BNP...Gene defects tied to inability of cells to repair DNA damage
...that individuals whose cells lack this repair will clinically present with Cockayne's syndrome." The findings ar... why you can have these specific mutations leading clinically to disease and what it tells you about the protein to protein interactions."Along with UNC, co-autho...Chemical from venom of Chilean tarantula could aid treatment of heart attack, other major diseases
...nd finding a drug company to turn the peptide into clinically useful drugs. ......n early indication of whether such therapy will be clinically active. The studies were conducted by David Berd, M.D., principal investigator, inventor of the AC Vaccine, and Professor of Medicine, Kimmel Cancer Center, Thomas Jefferson University. Dr. Berd commented, "This study has allowed us to determine t...UCSF finding could lead to long-sought alternative to morphine
...ating the human brain is. Kappa-opioids have been clinically available for 40 years, but have long been dismiss...idual drugs have at each receptor. There are three clinically available forms of kappa-opioids, nalbuphine, pentazocine and butorphanol. One possible explanation...UNC opens first clinical trial of vaccine treatment for advanced breast cancer
...e disease, defined by lack of progression measured clinically or radiographically over a period of one month the patient's cells must express the HLA (tissue type) A2 protein, which is present in 30-40% of the population. Patients will not know their tissue type and this will be evaluated prior to the coll......" said Dahn. "These new findings may eventually be clinically useful in providing novel insights into genetic diseases of the skeleton as well as the repair and replacement of cartilage and bone." Adds Fallon, "Another intriguing aspect of the work is that it may have implications for understanding how to bring...