Protein mimetics could lead to more successful coronary bypasses
..."We hope to be very applied in terms of looking at clinically relevant problems for which there's an unmet need, then developing experimental approaches to solving these problems, and then, based on experimental discoveries, engineer molecules that can be used to treat human disease." This research will be publ...Society report encourages preliminary sex analysis of clinical trial data
...ely being analyzed by sex. Without such analysis, clinically relevant information about potentially lifesaving treatments could be lost. "It seems clear that these analyses will serve to promote safer and more effective drugs for both men and women. As the field of clinical research advances, clinical trial ...The area where carcinogens settle may be a key factor in developing lung cancer
...otocols would the dose exposure be compatible with clinically observed sites. The authors of "Local Particle Deposition Patterns May Play a Key Role in the Development of Lung Cancer," are Imre Balashazy, from the Radiation and Environmental Physics Department, KFKI Atomic Energy Research Institute, Budapest, ...Don't ban embryo-based research says new chairman of European fertility organisation
...er embryonic or adult, agree that in order to find clinically viable treatments research must continue on both types. Judging from animal experiments, both cell sources may in the future prove useful. There have been spectacular results using embryonic stem cells in animal models of diseases such as Parkinson's...Non-drug treatment for hypertension found effective in hard-to-control refractory hypertensives
...ure reductions even in refractory hypertensives is clinically meaningful as it provides us with a much needed effective, and side-effect-free treatment option for this patient population"....JCI table of contents, July 15, 2003
...ifferentiation, so that they may ultimately become clinically useful in the repair of injured organs. In the July 15 issue of The Journal of Clinical Investigation, a collaborative research team led by Tsvee Lapidot and colleagues at the Weizmann Institute of Science in Israel, and also including researchers fr...Gene therapy prolongs survival, slows disease progression in ALS mice
...al, functional, and pathological improvements in a clinically relevant mouse model of a motor neuron disease. Says Fred Gage, "Adeno-associated viruses are retrogradely transported from the synapses in the muscle to the nucleus of the motor neuron inside the spinal cord, emphasizing the importance of basic sci...Development of hair depends on development of the hair channel
...in stem cells, and this technology has been useful clinically in the treatment of burns and wounds. However, cultivating hair has proven to be a far greater challenge," says Fuchs, professor and head of the Laboratory of Mammalian Cell Biology and Development at Rockefeller and a Howard Hughes Medical Institute...The genetic complexities of sensation-seeking behavior in alcoholic men
...king among alcoholic men. "Alcohol-dependence is a clinically heterogeneous disorder that arises from a combination of genetic and environmental biopsychological factors," said Frdric Limosin, a psychiatrist at the Albert Chenevier Hospital in Crteil, France and corresponding author for the study. "Substances s...Toxic protein could explain Alzheimer's and lead to breakthroughs
...e shown that ADDLs are present in humans and are a clinically valid part of Alzheimer's pathology. If we can develop drugs that target and neutralize these neurotoxins, it might be possible to not only slow down memory loss, but to actually reverse it, to bring memory function back to normal." Although both are......s' nervous system. To convert the findings into a clinically and commercially useful AIDS treatment, scientists must find a drug that interferes with the ATR gene only in white blood cells and without causing serious side effects, he adds. Details of the Pathway to Doom Here is how Planelles outlines the "pat...New study provides first linkage of fetal alcohol exposure and enlarged heart
... of hepatic glycogen deposition, and of exerting a clinically useful anti-inflammatory effect). Even brief prenatal exposure to elevated glucocorticoids can result in permanent adverse changes in the adult offspring's cardiovascular system. Glucocorticoids are important in normal development, but excessive exp...New clinical study uncovers mechanism by which chromium picolinate may enhance insulin sensitivity
...e study. Chromax chromium picolinate is the most clinically tested brand of chromium with proven efficacy for support of glucose metabolism. "This new research further supports the large body of scientific evidence showing chromium picolinate is a safe and effective addition to the diet for people with type ...Cancer biologists and a cardiologist take a new look at aggressive tumors
...ike" ability of aggressive tumor cells raises some clinically important issues. "This plasticity represents a clinical challenge in trying to detect aggressive tumor cells," Hendrix said. "But it also provides new insights on how we might target them more effectively." In addition to Hendrix and Weiss, the rese...Bracing is less effective in overweight teens with scoliosis
...than the 85th percentile and were considered to be clinically overweight. All patients were prescribed the thoracolumbosacral orthosis brace, which fits under the arm and around the rib cage, lower back and hips. On average, the teens wore a back brace for about 14 hours per day until beginning a weaning proto...Tufts University wins $25-million NIH contract
...he U.S., whether they are contagious and can cause clinically serious human infections, and if bioterrorists can readily produce them in large numbers and deliberately disseminate them through food and water. "The discoveries that will be made as a result of this award are going to have a profound impact on h...Hospitalization injuries prove costly to patients, health care system
...o identify medical injuries and, therefore, is not clinically precise for this purpose. For instance, some PSIs, such a postoperative hemorrhage, may be in part due to patient conditions and in part due to failure in care." Nevertheless, she added, the findings are strong enough to suggest that the nation's hos...New medicines at risk from biodiversity loss
...pical cone snails may contain the largest and most clinically important pharmacopoeia of any genus in Nature" says lead author of the study, Eric Chivian from the Harvard Medical School, "but wild populations are being decimated by habitat destruction and overexploitation. To lose these species would be a self-...Gene controls age at onset of Alzheimer's and Parkinson's diseases
...t disorders, the two exhibit a lot of overlap both clinically and pathophysiologically," said Jeffery Vance, M.D., director of Duke's Morris K. Udall Parkinson's Disease Research Center and associate director of the Duke Center for Human Genetics. "This study emphasizes the similarity between the two diseases b......doses used in breast cancer treatment is now being clinically implemented at the Institute of Cancer Research. Homogeneity of radiation doses is important in ensuring that radiotherapy is as effective and as safe as possible. As a result of an EPSRC funded project, the new technique isbeing verified via the use...