Landmark gene agreement announced by Samoan government and UC Berkeley for anti-AIDS drug Prostratin
...erkeley professor of chemical engineering, plan to clone the genes from the tree that naturally produce Prostratin and insert them into bacteria to make microbial factories for Prostratin. A similar technology is currently being explored to produce the anti-malarial drug artemisinin. "A microbial source fo...Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
...erkeley professor of chemical engineering, plan to clone the genes from the tree that naturally produce Prostratin and insert them into bacteria to make microbial factories for the drug. A similar technology is currently being explored to produce the anti-malarial drug artemisinin. "A microbial source for ...Single isolated mouse skin cell can generate into variety of epidermal tissues
... says Lowry. After expanding an isolated stem cell clone several million times, the researchers grafted the cells on to the back of a mouse that had no hair, and demonstrated that the grafted cells, all derived from a single parent stem cell, made new hair, skin and sebaceous glands, which excrete oil to l...Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
...ine embryonic stem cell line and engineered a cell clone to express fluorescent proteins so they could easily identify the location of the "newly" generated cardiac cells. They tested the cardiogenic capacity of the line and collected cells with high potential for becoming cardiomyocytes. Randomly assigned...Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
...to molecular biology," explained Smith. "We had to clone and purify the proteins, and test them in animals for toxicity and protection." RTA 1-33/44-198, the most promising vaccine candidate, was tested in three groups of ten mice each. One group received the purified protein alone; a second group recei...Scientists compare rat genome with human, mouse
...un (WGS) and bacterial artificial chromosome (BAC) clone sequencing techniques. To merge these into the final draft sequence, the Baylor group developed the Atlas software package for genome assembly. The resulting genome sequence was contained in 291 large segments, with a typical length of 19 million bas...Laboratory rat gene sequencing completed
...roach used both whole genome shotgun (WGS) and BAC clone sequencing techniques. To merge these into the final draft sequence, the BCM-HGSC developed the Atlas software package for genome assembly. The resulting genome sequence was contained in 291 large segments, with a typical length of 19 megabases (Mb)...New human embryonic stem-cell lines to be made available to researchers
...we distribute any reagents we publish, be it a DNA clone or any other cell line." Researchers requesting the cells will do so according to directions that can be found on a Web site run by Melton's group, which can be viewed at http://www.mcb.harvard.edu/melton/hues . After the request is received by staf...Transporter's function provides support for eating vegetables, limiting antibiotics
...acids to stay healthy. "We go and test it with our clone sitting in the refrigerator and it works," Dr. Ganapathy says. "It means normal colon cells express this transport system so they can make use of the products made by the bacteria. If these essential nutrients do not come in, cells become sick." An...Mice cloned from olfactory cells
...ic comedy Sleeper depicted scientists who try to clone a dead dictator from his nose. The current study ...esearchers, previous cloning efforts had failed to clone animals from the nuclei of any mature "post-mitotic" cells such as neurons -- that is, those that ha...Equine cloning's triple play sheds light on calcium, cell signaling, human disease
...ease in the two-week pregnancy rate of transferred clone embryos. Only two pregnancies lasted two weeks without manipulating calcium levels.Nineteen pregnancies lasted two weeks or more with calcium treatments. Of 21 pregnancies detected at two weeks, 11 lasted 30 days and five lasted 45 days. Three pregna...Advances in equine cloning may aid insight into human diseases
... variety of other animals, they had been unable to clone horses or their "equine" relatives until Idaho Gem. The research promised potential insights into cloning other species that have difficulty reproducing on their own, including many endangered species. Mules are created by breeding a male donkey wit...Human embryonic stem cells may promise medical advances
...blisher of Science Magazine --that any attempt to clone a human being would be highly dangerous and wrong, and therefore, all reproductive cloning should be banned," Kennedy said. "But, the generation of stem cells by somatic cell nuclear transfer methods involving the same individuals may hold promise fo...Researchers seek to clone 'mad cow disease' resistant cattle strain
...y Medicine (VMRCVM) at Virginia Tech are trying to clone cattle that are genetically incapable of developin...using the same somatic cell transfer technology to clone a cow without normal prions that PPL used to create Dolly the sheep and Mr. Jefferson, the first clo...OHSU team discovers compound that lacks estrogen's risks
...strogen's many positive functions. "We'd like to clone the receptor in order to effectively study its function, but we're not there yet," Kelly said. "That would be some time down the road, but with this new compound we now have a clear strategy for cloning this novel receptor." Peter Kohler, M.D., an...Mouse embryonic germ cells and male gametes created in the lab
...o create a new embryo - in fact, without having to clone at all. MALE GAMETES In the second phase of the research, the investigators asked whether the germ cells could be coaxed into becoming functional gametes - reproductive cells -- under laboratory conditions. Earlier this year, Hans Schler and collea...A little stress may be good for you
...ife on Earth," said Morimoto, who was the first to clone a human heat shock gene in 1985. ...Novel approaches to current cellular therapies continue progress toward disease prevention
... recipients used pre-transplant recipient cells to clone CMV-specific, non-donor reactive T-cells. Infusion with adoptive therapy did not cause rejection and it was followed by prompt recovery of CMV specific T-cell counts that were of recipient origin, unlike the other T-cells present in the body that ap...Plant immune system's 'take two aspirin' gene, offers hope for disease control
...turally in "excruciatingly small amounts," then to clone the gene that encodes it, and finally to assess the role of SABP2 in disease resistance. The PNAS article tells how the researchers proved that SABP2 is a key player in innate immunity by silencing the SABP2 gene and watching the plant immune system ......r mutants enabled Ganetzky's group to identify and clone a gene that encodes sodium-channel proteins in brain cells. The influx of sodium ions into brain cells through sodium channels is the essential step in generating nerve impulses. The isolation of the fly sodium-channel gene has spurred rese...