Landmark gene agreement announced by Samoan government and UC Berkeley for anti-AIDS drug Prostratin
... Once Keasling has pinpointed the key enzymes and cloned their genes, he plans to insert the genes into a strain of E. coli bacteria that he has created to produce isoprenoid compounds like Prostratin. The product of more than 10 years of genetic engineering, the bacterial factories have already proven use...Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
... Once Keasling has pinpointed the key enzymes and cloned their genes, he plans to insert the genes into a strain of E. coli bacteria that he has created to produce isoprenoid compounds like Prostratin. The product of more than 10 years of genetic engineering, the bacterial factories have already proven use...Newly discovered protein may be key to muscular dystrophy
...ations in a previously unidentified gene. The team cloned this gene, snf-6, and found that its sequence was similar to genes in a family of mammalian neurotransmitter transporters. Because analysis of mutants indicated defects in acetylcholine activity, they tested whether the expressed protein, SNF-6, tran...Body's own defense against H. pylori, cause of stomach ulcers and stomach cancer
...h the carbohydrate alpha 1,4-N-acetylglusoseamine, cloned previously in Dr. Fukuda's laboratory. Because the alpha 1,4-linked N-acetylgucosamine is confined to the stomach's deeper mucosa lining, which also lacks H. pylori, the scientists investigated the possibility that it might play a role against i...Malignant cancer cells generate mice through cloning
...ote," says Blelloch, "that the stem cells from the cloned melanoma were incorporated into most, if not all, tissues of adult mice, showing that they can develop into normal, healthy cells," such as those for skin pigmentation, immunity, and connective tissue. But in spite of this, when certain cancer-relate...Researchers in UGA Vet School discover a mechanism that blocks replication of a retrovirus
...enocarcinoma led to the death of Dolly, the first cloned mammal. It is a chronic problem for the sheep industry in Europe and the United Kingdom. "The cancer is caused by a retrovirus that passes from sheep to sheep like any other virus, such as the flu," Palmarini said. Like all viruses, retroviruses ins...Oxygen sensing in worms may hold key to healthy blood pressure in humans
...ygen was accomplished, Marletta and his colleagues cloned the genes that code for the heme-binding site of the guanylate cyclase and searched the genome databases for homologues in other organisms. A similar guanylate cyclase enzyme was discovered in Caenorhabditis elegans, the tiny primitive worm that has ...Gene alteration points to longevity, thinness
...and Ganapathy had been studying for years. So they cloned the Indy gene from the fruit fly but found it didn...s a maximal lifespan of about four weeks. Dr. Fei cloned all three of the acid transporters in the C. elegans, knocked down the activity of each and found th...Therapeutic cloning no longer a dream, says scientist who produced first cloned embryonic stem cell
...he first in the world to produce stem cells from a cloned human embryo told the 20th annual conference of th...ive cloning, where the aim would be to implant the cloned embryo into a woman in order to produce a baby. In therapeutic cloning, the embryo is destroyed af...Why does cloning create abnormalities? Scientists take a step towards finding out
...n, Germany: Significant abnormalities observed in cloned mice help reinforce the need to continue to avoid ...We found significantly impaired development in the cloned embryos compared with those derived from more conventional ART techniques", said Dr. Takeuchi, "and ...Therapeutic cloning may be permitted at Newcastle University
...ated Dolly the sheep in 1997. The project will use cloned embryos to create insulin-producing cells that can be transplanted into people suffering from diabetes. The procedure involves reprogramming cells from skin tissue of a patient who has lost important cells through disease or injury. The re-...Conflicting views on embryonic and adult stem cells complicate research in stem cell therapeutics
...apeutic cloning,' which involves the creation of a cloned embryo using the patient's DNA. Fuelling such controversies are stringent regulatory practices specifically in the United States such as President Bush's decree in August 2001 forbidding federal funding for research on ESCs, with the exception of tho...Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
...cells which can be obtained through muscle biopsy, cloned and reinjected into the body. MDC possess a high level of plasticity in response to environmental cues and are able to differentiate into different types of tissue. In this study, the University of Pittsburgh researchers injected MDC into the penis o...Govindarajan Dhanasekaran wins 2004 Sarber Award from American Society for Microbiology
... work on recovering infectious virus entirely from cloned DNA, which will help in the development of a recombinant virus vaccine. He has also studied how Newcastle disease virus (NDV), which also infects chickens, causes cells to die. This project has great potential for human medicine, because NDV coul...Genetic sequence identified for anti-bacterial sea slug protein
...ng on sea hares. Derby, whose team has sequenced, cloned and expressed Escapin, believes a natural or synthetic form of the protein could be manufactured for the marine industry as an environmentally friendly alternative to toxic heavy metals, such as copper, normally applied on materials to prevent biofil...Experimental smallpox DNA vaccine protects primates from lethal monkeypox
..., using a harmless device called a "gene gun," the cloned gene is expressed and presented to the immune system, which begins to produce protective antibodies against the virus. Following challenge with a lethal dose of monkeypox virus, the four groups of animals were closely monitored. Monkeys vaccinated w...More useful plants may sprout from gene role discovery
...o change cell wall make up, Chapple said. His team cloned the gene, called REDUCED EPIDERMAL FLUORESCENCE1 (REF1), which encodes an enzyme that is a member of the aldehyde dehydrogenase family. A similar enzyme helps the human body detoxify alcohol. "People thought that we'd have a hard time manipulating fe...New tumor suppressor may play important role in deadly brain tumors
...viously identified ING1. "The ING4 gene had been cloned simultaneously in both laboratories at the MGH and at the National Institutes of Health," says Garkavtsev. "Its functional role in the prevention of tumor progression had not been investigated. When we found that malignant gliomas have strikingly low...Researchers confirm novel form of the Rett syndrome protein
...ospital for Sick Children. Adrian Bird originally cloned the MECP2 gene in 1992 while in Vienna, Austria at the Institute for Molecular Pathology. In October of 1999 Huda Zoghbi of Baylor College of Medicine and the Howard Hughes Medical Institute announced that mutations in the MECP2 gene were the leading...... journal Science. The researchers, who last year cloned the first wheat vernalization gene, VRN1, discovered that VRN1 and VRN2 work together to confer the winter growth habit. They showed that loss-of-function mutations in either of these two genes result in spring wheat varieties that don't require cold...