Protein essential for making steroids turns out to be a "molten globule"
...olesterol-transfer process. These groups also have cloned the gene that controls the StAR protein, and haveshown that a rare inherited disease is caused by mutations of that gene. Thedisease provides stark proof of the essential role of steroid hormones. Children born with the rare disease, congenital lipo...Newly discovered gene family may regulate important biological processes
...ts for male infertility and cancer. The scientists cloned the gene, Morc, in both mouse and human cells. It is foundonly in the testis, but similar proteins also are in other tissues in all themulti-cellular organisms tested, including zebrafish, nematodes, slime mold andplants. "Morc is apparently part of ...Study points to possible gene therapy cure for hemophilia
... Studies in mice involved attaching a cloned gene responsible for humanclotting factor VIII - a... test AAV factor VIII gene transfer in dogsusing a cloned canine factor VIII gene. This will reduce the likelihood that theanimal's immune system will mount a...University of Hawaii scientists announce first male clone
...in theovaries, used to clone the mice. Even cattle cloned in Japan are reported tocome from cells related to the femal reproductive system. To create male mice,UH scientists have now used cells taken from the tip of adult male tails. In the Honolulu Technique, the nucleus extracted from a donor cell is inje......n fact, five Toll-like receptors haverecently been cloned and several others have been identified. In this study using human endothelial cells (cells that line the blood vessels)and human monocytes (blood cells that are important in fighting infection), theresearchers provided proof that endotoxin uses a To...Studies Of A Gene For A Rare Form Of Rickets Shed Light On Vitamin D Deficiencies
Two years after they cloned the gene for a vital kidney enzyme, vitaminD-1-alpha hydroxylase, researchers at the University of California San Franciscoare beginning to understand how the enzyme works. They are learning how it isregulated normally and how it acts abnormally in b......ancer. Using recombinant DNA techniques, Bernstein cloned hCdc5 in 1997 and showed thatit is a novel human protein involved in the division of human cells. Since then,he and his research team have shown that it binds to DNA and acts as atranscription factor -- it regulates genes that instruct a cell to star...New Gene May Play Important Role In Regulating HDL, The 'Good' Cholesterol
...n the study, originally purified the EL proteinand cloned the new gene. The Penn scientists, led by Rader, furthercharacterized the gene and the EL protein, performing a series of experiments inmice that demonstrated the protein's likely role in HDL regulation. For the mouse studies, Rader's group used gen...Millennium Clones Diet-Induced Obesity Gene
...illennium Pharmaceuticals, Inc. (Nasdaq: MLNM) has cloned the first gene that can suppress diet-induced obesity in mice. The gene may have strong implications in developing therapies to intervene inhuman obesity, the authors note in their report, which appears in the March 11,1999 issue of Nature. The scien......tead of turning sharply toward it. When he cloned the genes underlying stop short and bypass, Van Va...e bottom of the pathway. The first gene he cloned caused the stop short phenotype. It turned outto be profilin, a much-studied protein actin known bin...Researchers isolate gene that helps plants take in iron from soil
...plants need for growth. The ferric reductase gene, cloned by Guerinotand colleagues from the common weed Arabidopsis, produces an enzyme thattransforms ferric iron, the most common form of iron found in soils, intoferrous iron. The ferric reductase enzyme straddles the surfaces of the plant'sroot cells in a...Human/Insect/Jellyfish Genes Team To Quiet "Hyper" Nerve Cells
...euroscience, theresearchers took "silencing genes" cloned from electrically quiet human hearttissue and ferried them into cultures of rat spinal tissue using non-harmfulviruses that readily infect nerve cells. Once turned on inside the spinal nerve cells, the genes generated finechannels in the cel...UD Valentine Science: Cell "Dating" Habits May Promise Healthier Hearts
...nteraction. In this way, Naik can screen a million cloned proteins for naturally formingcouples--a widely used technique, which he described in the Journal ofBiological Chemistry (Feb. 21, 1997, vol. 272, no. 8, pp. 4651-5654)."When one or two yeast colonies change colors," he explains, "I know that theya...Gene Knockout Prolongs Ovarian Lifespan In Mice
...f throughout the animal'slifetime.) Bax was first cloned by Stanley Korsmeyer, MD, a member of theresearch team who also produced the Bax-knockout mice. Korsmeyer was with theHoward Hughes Medical Institute at Washington University School of Medicine inSt. Louis while this study was conducted and is now at...Programmable Cells Open Window Of Opportunity For Gene Therapy
...nismbehind the creation of Dolly, the first animal cloned from adult cells. "Theyknew the cells were reprogrammed, but they had no idea of the mechanism," Dr.Krawetz said. He has identified the mechanism and has learned how it works.The ramifications for gene therapy are tremendous, he remarked. "It is oure...Human Neural Stem Cells Advance Distant Prospect Of Reseeding Damaged Brain
...gues reportedin Nature Biotechnology that they had cloned a human neural stem cell-one of thefirst times a h... of one aborted fetus several years ago. When they cloned individualcells, they gave rise to both neurons and their support cells, the glia. Nextthey grafted ...Gene Therapy Trial Approved For Rare Anemia
... of correctingthe blood disorder by transferring a cloned corrective gene called FAA into apatient's very primitive bone marrow cells - "progenitor" stem cells from whichall blood cells are formed. These progenitor cells, which have been removed frombone marrow for the gene transfer, are then re-infused int...Jackson Laboratory Researchers Identify Neuromuscular Degeneration Gene
...ARBOR -- Scientists at The Jackson Laboratory have cloned the gene for themouse mutation known as neuromuscular degeneration, or nmd, an advance thatcould boost research into such devastating neurological diseases in humans asamyotrophic lateral sclerosis and spinal muscular atrophy. The results are...Key Asthma And Allergy Molecule Pictured
...n was present." The gene for the IG-E receptor was cloned 12 years ago by Jardetzky'scollaborator, Jean-Pier...and Immunology at Harvard Medical School. "When we cloned the receptor, we hoped we could start developing agents totarget the receptor," Kinet said. "It is s...Gene Identified For Heart Defect That Causes Sudden Death In Young People
...ics that ifwe get any luck at all we could have it cloned within a year. We are certainlyputting a lot of effort into it. "By finding the cause of an inherited disease we can design targeted therapiesand understand similar diseases that cause sudden death and heart failure,"Roberts says. He cites as an exam...