Cloning pigs and drug discovery among 'hot' topics
...opments. But last week's news of the world's first cloned double "knockout" pigs represents a major boost to...an, one of the creators of Dolly, the first animal cloned from an adult cell, at today's congress. Formerly with PPL Therapeutics, PLC, where the work with t...CWRU scientists reveal how magnesium works on ion channels important for regulating blood pressure
... Clinic Foundation was key." CWRU researchers used cloned ion channel DNA to express the ion channels in frog eggs. The ion channels are proteins made of various amino acids; the researchers mutated some of these amino acids and recorded functional change that resulted from the mutations. Hypertension, Cui ...Subtract a gene and feasting mice add no fat
...m the disease. The mouse SCD-1 gene was found and cloned by Ntambi and colleagues in 1988 when he was a post-doctoral fellow with Daniel M. Lane at the Johns Hopkins University Medical School in Baltimore. He developed the knockout mouse model in 2000 while on the Wisconsin faculty. The human equivalent of...First drug developed for widespread use against botulism
...ant refers to the fact that the antibody genes are cloned into a manufacturing cell line, so unlimited quantities of the antibodies can be produced by the cultured cells. Oligoclonal means that the drug involves a combination of a precise, small number of antibodies. Although ten monoclonal antibody drugs a...New predictive marker found for prostate and colon cancer
...hip at Boston's Dana-Farber Cancer Institute, Ross cloned the protein from bone marrow cells of a patient with leukemia. Since joining the U-M Medical School three years ago, she has focused on nothing but HIP1 and its relationship to an important cellular trafficking and signaling system called the clathri...Research identifies enzyme involved in fat storage
...s and decreased appetite. Friedman's research team cloned the ob gene in 1994 and discovered leptin in 1995. Since then, much of Friedman's research has focused on understanding how leptin exerts its effects on body weight, food intake and metabolism. In their latest studies, Friedman, Paul Cohen and coll...Researchers discover molecular 'switch' that tells body to store or burn fat
... acids. Co-author Ntambi and colleagues originally cloned the SCD-1 gene in 1988 together with M. Daniel Lane, Ph.D., at Johns Hopkins University. "SCD-1 has since been found to be very important for the synthesis of oleate despite the fact that mammalian diets supply abundant dietary oleate," says Ntambi, ...Marijuana receptor gene abnormality in schizophrenia
...re encoded by the CNR1 gene (MIM114610), which was cloned by Matsuda et al in 1992. CB1 is located at 6q14-q15, which was included in a schizophrenia susceptibility locus, 6q13-q26, revealed by Cao et al using two independent series of pedigrees, which was designated by Schizophrenia 5 (SCZ5, OMIM 603175)....Clonal human (hNT) neurons re-establish connection in rats with severe spinal cord injury
...a, FL (July 1, 2002) Human neurons grown as cells cloned from a tumor helped restore the function of severely injured spinal cords in rats, University of South Florida researchers say in a study released this week in the Journal of Neurosurgery: Spine. "Transplants of these specially treated cells were us...Researchers identify protein that regulates killer cells
... was sent back to the Swiss researchers where they cloned its gene and sequenced its DNA. That gene, they discovered, is a key component involved in regulation of "natural killer cells" - cells produced by the body's immune system that attack foreign or mutated cells like caused by viruses or cancer. "This ...Mechanism that enables fetus to survive in mother under study
...sigma receptor interacts with cocaine. In 1996, he cloned the sigma receptor from human placental tissue so ... can establish that without any doubt by using our cloned receptor,'" Dr. Ganapathy said. "So instead of taking tissue and looking at the progesterone binding...Genetic engineering could salvage once-promising anti-cancer agents
...mic library. Theyused a gene that already had been cloned from another microorganism(Amycolatopsis mediterranei) as a reference to screen the library and findthe genes needed for maytansinoid construction. Having access to the genesthat control the formation of maytansinoids allows scientists to manipulatet...Children's Hospital Boston researchers use therapeutic cloning to create functional tissue in cows
...sues created from heart, skeletal, and renal cells cloned from cows, then transplanted back into the animals...eated from heart, skeletal muscle and kidney cells cloned from adult cow skin cells. The cloned cells were harvested, expanded in culture and transferred to ...1st evidence that nuclear transplantation ('therapeutic cloning') can eliminate tissue rejection
...rt 'patches' and miniature kidneys engineered from cloned cells were successfully tested in a large-animal m...study furnishes the first scientific evidence that cloned tissues can be transplanted back into animals without being destroyed by the body's immune system. ...Statement by the Ethics Advisory Board of Advanced Cell Technology, Inc.
...undertaken by ACT and approved by the EAB. It uses cloned bovine fetuses of 5-6 weeks' gestational age. The ethical rules for humans and livestock animals are different. While the reported research is appropriate in animal studies, it should never be done in human beings. Strict guidelines established by th...Muscle derived cell transplants offer alternative incontinence therapy says Pitt study
...his population was then genetically engineered and cloned to form a large population. These cells were then injected into the bladder walls of mice. The bladders of the mice were evaluated at one, four and eight weeks and 6 months. On evaluation, researchers noted the presence of myofibers, or differentia...'Warm to the touch' gene found
...rtis Research Foundation (GNF) have identified and cloned the first-known gene that makes skin cells able to...r this year, the TSRI and GNF group identified and cloned the genecalled TRPM8 that codes for the first-known signaling molecule that helps the body sense col...Gene thats key to cloning success also hints at serious hurdles to reproductive cloning
...ngle gene is a powerful predictor of whether newly cloned mammalian embryos will survive and thrive, but the genes sporadic expression in cloned mouse embryos casts fresh doubt on prospects for reproductive human cloning. The findings, by a team...Scientists trace recently found genes to the evolution of big brains
...ratory and the papers lead author, led a team that cloned the Olig genes in 2000, but at that time their function wasnt clear. These latest findings by Stiles, Rowitch and their colleagues show the unanticipated breadth of Olig gene functions during the development of the spinal cord. To figure out the gene......y only the beginning of the story." Once the team cloned the gene, however, its similarity to IL-10 and two other related interleukins, IL20 and IL22, was apparent, Liang said. Further research to test binding between IL-24 and the known receptors in the IL-10 family found that IL-24 binds to two different...