Northwestern team identifies first enzyme in mammalian circadian clock
... development to come out of my laboratory since we cloned the mammalian circadian gene, Clock, in 1997." While casein kinase I epsilon, or CKIe, is the ninth gene to be identified with circadian rhythms in mammals, it is the first gene that acts as an enzyme. Circadian (Latin for "about a day") cloc...Cockroach birth control from gene discovery
...h. The entomologists say they have identified and cloned a key gene in the reproductive system of the male cockroach. Success in cloning five P450 genes from the German cockroach was announced by Zhimou Wen today (March 28) at the national meeting of the American Chemical Society (ACS) at the Moscone Conve...UCSD study of uncoordinated fruit flies provides molecular clues to hearing problems in humans
...this gene, confirming nompC's identity. "Once they cloned nompC, everything was clear," said Peter G. Gillespie of the Oregon Hearing Research Center and Vollum Institute at the Oregon Health Sciences University. "nompC is definitely part of the fly transduction channel, either the pore itself or a princi...Uncovering structure of cellular switch could aid design of cancer-fighting drugs
...ammalian Cdc42 protein originally was purified and cloned at Cornell by researchers in Cerione's laboratory in 1990. Cdc42 is believed to play a dual role, alternating as an essential protein for normal cell growth and as a switch that allows protein from a mutated Ras oncogene to cause cancer. Many of ...Evolutionary implications: myoglobin-like proteins found in ancient microorganisms
...at Manoa's College of Natural Sciences. Their team cloned the genes expressing these proteins, which were then purified and characterized. The newly discovered proteins from the ancient microorganism Halobacterium salinarum and the more widely known bacterium Bacillus subtilis share similar properties. Thes...Deadly to cattle and humans, prions may help other organisms survive, researchers find
...rmed aggregating proteins. <P. The researchers cloned and characterized the portion of the yeast protein - called Sup35 - that controls aggregation into sheet-like prion structures. They did this for a range of budding yeasts, the group that includes the kind used for centuries in baking and brewing. ...UroGenesys researchers discover new target antigen for prostate cancers
...nign prostatic tissues. Once they hadsuccessfully cloned STEAP (named for Six-Transmembrane Epithelial Antigen of the Prostate), theUroGenesys team looked for its presence in a wide variety of normal and diseased tissues. Theresearchers confirmed high cell-surface expression of STEAP in all human prostate...Key developmental genes identified, linked to rare syndrome
...research team. Last year the group identified and cloned mouse and human versions of two genes called Dnmt3... satellite repeats. When Li's team identified and cloned the human equivalent of Dnmt3b last year, the gene mapped to an area of chromosome 20 that other res...Wake Forest scientists clone gene for inherited kidney stone disease
...University School ofMedicine report that they have cloned the gene responsible for an inherited formof kidney stone disease, which may open the way to new treatments. The disease, called primary hyperoxaluria type II, "often results in theformation of kidney stones at a very young age," said Ross P....Wistar Institute scientists find key piece in gene regulation puzzle
...ity of Rochester and co-author ofthe Nature paper, cloned the protein, HAT type A, now called tGCN5. When D... activation. Other proteins with HAT activity were cloned shortly after Dr. Allis' discovery. Among them were hTAFII 250 and p300/CBP, two other previously id...Enzyme discovery may link underlying processes in cancer and heart disease
...understood. Dr. Lambeth and his colleagues first cloned the human Mox1 gene based on itssimilarity to an enzyme that generates reactive oxygen in neutrophils as amechanism to kill bacteria. They then introduced the Mox1DNA into mouse cellsand were surprised to observe that the cells took on the appearanc...Gene protects tubby mouse strain from hearing loss
...udesob (obese), db (diabetes), and cpefat. Tub was cloned in 1996 by theNishina/Naggert group at The Jackson Laboratory and identified as a novel geneon chromosome 7. Dr. Nishina and her colleagues have found that the tub mutation is amember of a novel family of genes that is widely distributed amon......ad company involved in thedevelopment of Dolly the cloned sheep, uses recombinant DNA technology -- inwhich a gene from one organism is inserted into the DNA of another -- to create"transgenic sheep" that produce the human protein alpha-1-antitrypsin, or AAT.The protein is then extracted from the milk. With......ids are made by an enzyme produced by a gene first cloned atNIEHS -- and the gene itself, when implanted in ... NIEHS, a senior co-author on the study,originally cloned the CYP2J2 gene. "Since our studies have thus far beenlimited to tissue cultures and mice, we are s......antibodies - identical copies of animal antibodies cloned andreproduced in the laboratory. (See page 107, MEDI 156, 9 a.m., Monday, August23, Convention Center, Room R09 in the final program.) - Brain Chemical Imbalances Shed New Light on Alcoholism: A series of studiesabout alcohol's effects on your brain...University Of Toronto team discovers salt tolerance gene in plants
...sensitive plant that grows rapidly, theresearchers cloned the gene coding for the antiport and modified the plant tooverproduce the antiport protein. Unlike other genetically modified plants,overproducing the antiport involves manipulating a protein already present asopposed to introducing a foreign protein...UW-Madison team develops technique to create flu viruses
...ble from a basic science perspective. They can use cloned viruses to study influenza viral growth, pathogenesis, and what allows some viruses to transmit across species. For example, avian flu viruses almost never transfer to humans, but when they do they can be particularly deadly, such as the 1997 Hong Ko...First complete physical map of a higher plant genome
...l map of a genome shows the localisation of all cloned DNA-segments of an organism in relative order and distribution over the different chromosomes. The existing Arabidopsis physical maps were predominantly based on YACs (yeast artificial chromosomes, a system for cloning and maintenance o...Nature publishes secret of abalone shell strength
...nter. "From studies in our lab in which we cloned the gene that codes for thisprotein, we're able to see a unique 'modular' structure that makes the proteinlook like a series of springs or shock absorbers linked together," said Morse. The experiments revealed that these springs are uncoiled ......entified the CFTR mutation in 1989 andsubsequently cloned the responsible gene. A flurry of research followed,much of it focusing on gene therapy, which tries to correct the geneticdefect in the nucleus of cells, upstream of the chain of events that makethe CFTR protein. Several gene therapy clinical trials...