Tag: "clotting" at biology news

Mitochondrial genes cause nuclear mischief

... a hemophilia patient with a NUMT interrupting his clotting factor gene. Much remains to be learned about the functional and temporal dynamics of NUMT insertions, but their potential for harm suggests that many NUMTS, unlike much of the rest of the flotsam that litters our genome, may be selected against quic...

Streptococcus infects humans by thwarting blood clotting

...ts, as well as our immune cells, trigger the human clotting system, which evolved in part as a defense against...d." Sure enough, when the researchers bypassed the clotting defense by injecting the streptococcus directly into the bloodstream of both normal and transgenic m...

Strep disrupts blood clotting to infect humans

... an enzyme called streptokinase to block the blood clotting response and allow themselves to move more freely ...ria cause a local infection and begin to grow, the clotting system produces clots in the blood vessels around the infection, closing the highways that the bacte...

Rutgers-Newark scientist: Mosquitoes may carry lethal parasite

...itoes secrete an anti-coagulant to keep blood from clotting as they drink, temporarily leaving a clear passage directly into the bloodstream. New research by Cali and one of her graduate students will be aimed at identifying how prevalent B. algerae is in mosquitoes in New Jersey through the collection and ex...

How wounds heal Clues from flies

... well-characterized response marked by rapid blood clotting and a recruitment of epidermal cells to the injury...wound, the researchers observed the familiar blood clotting and spreading of epidermal cells to promote healing. Since this epidermal spreading resembles that s...

Lupus Research Institute awards $3 million in novel research grants to further new science in lupus

...y's study will investigate the mechanisms of blood clotting in antiphospholipid syndrome (APS), a condition present in one-third of lupus patients that can lead to strokes, heart attacks and pregnancy loss. Researchers will use novel approaches to measure tissue factor activity to explain why some lupus patie...

Nonalcoholic beverages may impart cardiovascular benefits without the negative effects of alcohol

...ease in thrombin generation. Thombosis refers to clotting within a blood vessel, which may cause the death or decay of tissues supplied by the vessel. "Less thrombin means less thrombosis and less intima thickening," said Bassus. "Conversely, the acute consumption of alcohol beverages causes an increase o...

March of Dimes awards $250,000 prize to pioneering scientist

... include genes that are necessary for normal blood clotting as well as genes for normal muscle and brain funct...ding disorder hemophilia is caused by mutations in clotting factor genes that are located on the X chromosome. The disease occurs in about 1 in 5,000 males -- ...

Jay Levy honored with 2004 Abbott Laboratories Award in Clinical and Diagnostic Immunology

...emoved HIV from blood products and made receipt of clotting factors safe for hemophiliacs. Levy went on to discover a novel noncytotoxic antiviral response in CD8+ cells, where immune cells suppress HIV without killing the infected cell. This immune response has since been observed with other viruses and i...

Vanderbilt doctors use Viagra to treat infants with pulmonary hyptertension

...ypertension. It could be vessels that are prone to clotting or scarring after surgery, or vessels throughout the lungs that have a tendency to tighten, reducing the freedom of blood flow from the lungs back to the heart. During the procedure, Moore tried a drug well known to reduce deadly pulmonary hypertens...

JCI table of contents, 2 April 2004

...however, when patients develop antibodies to these clotting factors, neutralizing treatment. An alternative treatment is the infusion of a recombinant Factor VII (FVII), a procoagulant reaction activator that is independent of FVIII and FIX. But this treatment is extremely costly and the recombinant FVII has...

'Bat saliva' drug and new MRI techniques offer hope for acute stroke treatment

...lood clot without affecting the rest of the body's clotting system and without increasing the risk of intracranial bleeding. The DIAS study was a multi-center, Phase II study. Forty-four hospitals from Europe, Australia and Asia participated and 25 centers recruited a total of 102 patients. Patients eligible ...

JCI table of contents, January 2, 2004

...nance of hemostasis the balance of blood flow and clotting because they provide the site of assembly for a v... of the vascularization process. This dual role in clotting and new vessel formation suggests that annexin II is an indispensable factor in hemostasis and a pot...

Drug shows promise for Ebola virus treatment in primates

...fected with Ebola virus, the macrophages express a clotting protein, called tissue factor, on their surfaces. These cells are then attracted to the blood as it flows through the body, forming localized clots that pave the way for abnormal bleeding. Using rNAPC2, according to Geisbert, essentially blocks the ...

New advances in thrombosis help further understanding of disease prevention

...hrombin by the action of various activators in the clotting of blood) and an increased risk for venous thrombo...dition leading to increased bleeding and decreased clotting ability. Treatment with enoxaparin significantly increased the rate of live births compared to pati...

Premier international meeting provides latest news and issues in blood disorders

...emia, HIV-AIDS, leukemias and lymphomas, and blood clotting disorders. The Plenary Policy Forum (scheduled for Sunday, December 7, from 12:15 p.m. to 1:15 p.m. PST), will address health insurance coverage issues in the United States, and will feature the Honorable John Kitzhaber, M.D., former governor of...

Scientists uncover novel role for estrogen in bone marrow

...atelets circulate in the bloodstream to facilitate clotting and halt bleeding. Platelets are derived from a specialized bone marrow cell called a megakaryocyte. A mature megakaryocyte extends long cytoplasmic processes (termed proplatelets) from its cell surface that, in one of the most dramatic morphological...

Anti-platelet drug blocks bone metastases in mice

... able to block metastasis and only partially block clotting function." The results are published today in the online early edition of the Proceedings of the National Academy of Sciences. Weilbaecher's research group has been studying connections between bone metastases and osteoclasts, cells in bone marrow t...

Patients with atrial fibrillation undertreated for stroke risk

...on to monitoring and maintaining appropriate blood clotting factors maximizes the benefit and minimizes the risk. University Hospitals of Cleveland and University Hospitals Health System offers a Coumadin Clinic to more than 700 patients who are regularly monitored for treatment of various disorders, includi...

Researchers identify clotting protein which causes hepatitis B

...dy provides compelling evidence of the role of the clotting protein molecule fgl2 in viral chronic hepatitis, ...s studies in mice of the importance of fgl2 or the clotting protein in viral disease," says Dr. Gary Levy, Medical Director of the Multi-Organ Transplant Progra...

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