Biocompatibility to widen scope of biomaterial applications
...terials' applications. "Thrombosis involving blood coagulation and adhesion of blood platelets to biomaterial surfaces as well as fibrous-tissue encapsulation of biomaterials that are implanted in soft tissues are two challenging issues for researchers in quest of biocompatibility," says Technical Insights Analy...Nonalcoholic beverages may impart cardiovascular benefits without the negative effects of alcohol
...e effects that nonalcoholic beer may have on blood coagulation and platelet function. Findings include inhibited blood coagulation and platelet activation, both of which can reduce the risk of coronary artery disease. Research on ...JCI table of contents, 2 April 2004
...er caused by mutations in the genes encoding blood coagulation factors Factor VIII (FVIII) and FIX. The standard treatment is replacement of the missing proteins intravenously. Complications often arise, however, when patients develop antibodies to these clotting factors, neutralizing treatment. An alternativ...New polyelectrolyte inks create fine-scale structures through direct writing
...al structure, the extruded ink is deposited into a coagulation reservoir containing deionized water and isopropyl alcohol, Gratson said. Solidification of the ink is induced by electrostatic interactions in a water-rich reservoir or by solvent-quality effects in an alcohol-rich reservoir. A careful balance is ...New roles for protein modifications in cell migration
...ogical and pathological processes, including blood coagulation disorders, rheumatoid arthritis and asthma. These proteins act to proteolytically release membrane-bound growth factors or to disrupt components of extracellular matrices such as collagen and proteoglycans (which help to build skin and soft tissue), ...Early promise for treatment of Ebola
...ans. The virus is thought to cause excessive blood coagulation and thrombosis leading to organ dysfunction. Inhibition of the blood coagulation pathway could therefore be a potential therapeutic approach for ebola treatment. Thomas W Geisbert f...Use of new direct thrombin inhibitor may be as effective as current standard treatment
...nd clot-bound thrombin, a key enzyme in the body's coagulation pathway. "We believe that ximelagatran holds promise as a new agent for the treatment of venous thromboembolism, a sometimes fatal disease that affects an estimated 250,000 to two million Americans a year," said Charles Francis, M.D., of the Univer...New advances in thrombosis help further understanding of disease prevention
...l classes: (1) anticoagulants, which inhibit blood coagulation and serve to weaken already formed clots, preventi...azaxaban, a new oral, directly acting inhibitor of coagulation factor Xa. Results showed that razaxaban administered at 25 mg twice a day (bid) appears to reduce ...Researchers identify clotting protein which causes hepatitis B
...od or fibrin clots are the clumps that result from coagulation of the blood, and may cause partial or complete blockage of a blood vessel. This deprives the tissue of normal blood flow and oxygen, resulting in damage or death of the tissue. Corona viruses are named for their corona-like (halo) appearance in ele...Hemocellular Therapeutics establishes licensing agreement with UNC, ECU
...as served as ECU's scientific director of clinical coagulation programs for 15 years. Fischer is scientific dire...wen lab has a worldwide reputation in the field of coagulation therapeutics. We are extremely fortunate to have researchers affiliated with this lab informing our ...Bleeding disorder tied to defect in cellular transport mechanism
...e same disease state. (MCFD2 is short for multiple coagulation factor deficiency 2.) The team identified seven distinct mutations in the MCFD2 gene which appeared in nine of the 12 families studied. The researchers propose that these two proteins, LMAN1 and MCFD2, bind together to form a transporter which is sp...JCI Table of Contents, May 1, 2003
...ess/17246.pdf Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer AUTHOR CONTACT: Roland W. Herzog The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. Phone: 215-590-4907 Fax: 215-590-3660 E-mail: rwherzog@mail.med.upenn.ed...Boston chemist wins national award for research with enzymes, antibiotics
...e breakdown of food, the assembly of hormones, the coagulation of blood, and the processing of neurological signals and many other functions. "We're interested in what enzymes actually do, how they do it, what goes wrong and whether we can fix it," said Walsh, a biological chemist and professor at Harvard Medica...Gene variant discovery could save blood in surgery
..., making it one of the most common inherited blood coagulation mutations. Individuals with factor V Leiden are at increased risk of forming blood clots, especially deep venous thromboses. Because factor V Leiden carriers have blood with an increased tendency to clot, Donahue and colleagues wondered whether the ...UCSF celebrates opening of new vascular research laboratory
...earch Institute. Protease-activated receptors and coagulation proteases in blood vessel development. 2:45 3:15 Napoleon Ferrara, MD, Genentech fellow in the UCSF department of molecular oncology. New insights in the regulation of angiogenesis by Vascular Endothelial Growth Factor (VEGF) and novel factors. 3:...Case Western Reserve University researchers developing new treatment for cardiovascular disease
...lets that form in response to vascular injury, and coagulation factor VII-derived peptides that target the receptors on damaged endothelial and vascular smooth muscle cells. The team plans to evaluate the liposomes targeting ability in rat models. For the liposome to succeed as a cardiovascular drug carrier, it...Patients with serious kidney disorder produce natriuretic peptides at above average rates
...ndary to vascular stress caused by hyperlipodemia, coagulation disorders, and renal failure. That CNP urinary production was reduced by a low protein diet offers a theory that production of this peptide reflects activity in the kidney rather than reduced renal clearance of plasma CNP. Essentially, CNP productio...New gene therapy tool successfully treats mice with hemophilia A
...es in all populations and is caused by a defect in coagulation factor VIII. The mutation renders the factor VIII gene non-functional resulting in recurrent, non-predictable, spontaneous bleeding into major joints and soft tissues. Currently, the disorder is treated with injections of factor VIII protein in res......directly into a profusely bleeding wound to effect coagulation within seconds. Tests conducted for ONR by Dr. Hasan B. Alam at the Uniformed Services University of the Health Sciences were so impressive that the FDA cleared the product earlier this month. Acquisition by the Marine Corps seems imminent, and the......results in spontaneous bleeding due to the lack of coagulation factor 8 (FVIII) in the blood. Because hemophilia ...lia B (a related disorder that affects a different coagulation factor), development of gene therapy for hemophilia A has lagged behind. Current clinical therapy g...