Tag: "coagulation" at biology news

Clean water for Nepal is focus of MIT research

...said it was too much work. "Ten years research on coagulation down the tubes," Murcott said with a laugh. "But I dont mind. The idea is to solve the problem." They turned to filtration. "Junko Sagara (MEng 2000) looked at current filtration methods in Nepal and their shortcomings," Murcott said. One such system...

Selected estrogen compounds modify risks of vein clotting, a response to hormone replacement theraphy

...mselves, decreases in blood flow and increases in coagulation of the blood. Estrogen replacement drugs are known to alter coagulation, but little is known about affects on veins. Veins are composed on a cell lining called endothelium and smooth muscle which contracts and relaxes resulting in changes in diamet...

Fatal thrombotic disease in designer mice lacking vascular thrombomodulin

...coagulopathy. Continuous low-dose exposure to the coagulation inhibitor warfarin prevents these symptoms and allows mice to survive despite the lack of TM, confirming that the disease is one of uncontrolled thrombosis. Males and females show different rates of disease progression in this strain, but the basis ...

'Why isn't the neural tube defects rate lower?,' asks March of Dimes

...es the side effects related to the production of a coagulation protein in the liver, which causes blood clots to form in the legs. Other proteins in the liver may also interfere with the ability of estrogen to reduce blood pressure. "This side effect is much less likely to occur in women on transdermal estro...

Study finds nonviral gene therapy for severe hemophilia a is safe with early signs of benefit

...ary bleeding disorder due to a defect in the blood coagulation factor VIII gene. The disorder has an incidence of 1 in 5000 male births and affects approximately 15,000 men in the United States. Patients experience recurrent bleeding throughout their lives, and depend on intravenous injections of replacement fa...

Tobacco settlement $ = biomedical research; business development

...e therapies for cancer. --Learning how a key blood coagulation protein changes with age. --Creation of a new biosensor to detect bacteria and viruses. --Studying the effects of a "good" cholesterol protein on heart disease. --Finding the gene for macular degeneration---one of the leading causes of blindness in o...

Faster coagulation rates found in natural systems could impact industrial processing

...logical aggregates form in aqueous systems. Such coagulation processes are important in wastewater treatment an...ter already containing bacterial aggregates. The coagulation rate, or the rate at which the beads attached to the bacterial aggregates, was calculated by using a...

Awareness, quick action key to battling canine bacterial disease

...hemorrhaging typical of disseminated intravascular coagulation develops which is associated with coughing up blood, bleeding from the nose, severe bruising of the skin, and in some cases, bloody diarrhea. Profound hypotension and toxic cardiomyopathy may develop. At this point, antibiotics and even with aggressi...

Another component of the blood clotting machinery unraveled

Insights in the molecular steps of the coagulation cascade / Relevance for cell-membrane interactions...determined the structure of an important domain of coagulation factor Va. This opens new insights into the molecular details of blood coagulation, as well as in th...

U-M scientists identify genes that make blood "thicker" and more likely to clot as we get older

...in Factor IX and blood coagulation. Itexplains why coagulation capacity is almost twice as high in older people a...individual variations." When mammals are born, the coagulation capacity of their blood is only 40percent to 45 percent of a young adult's, Kurachi explains. After ...

Experimental Drug Derived From Snake Venom Shows Promise In Reversing Effects Of Stroke

...hree days so you dont have the dramatic changes in coagulation that youcan get with other types of clot-dissolving therapy."...

Engineering New Enzymes

...in with a gene segment for a subdomain from the coagulation proteinase factor Xa. The hybrid protein was expressed in E. coli and folded into a functional serine proteinase as shown by X-ray crystallography and enzymatic assays. While its catalytic activity was comparable to that of trypsin and fa...

NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs

...bout antithrombin -- a protein which controlsblood coagulation in human plasma. Successful crystal growth in space made itpossible to further define the molecular structure of the protein and how itworks in the human body, which has important implications for medicine. A space-based study of the ...

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