New 'Twist' In Proteins Offers Possible Route To Improved Antibiotics
...d of the enzyme,called the COOH-terminal, features coils called alpha helices that are farmore common protein structures. The crystallography revealed that the left-handedbeta helices were triangular in shape, with each side of the triangle formedfrom a roughly repeated six-amino acid, or hexapeptide, sequ...A Sensor, A Switch, A Zipper: Protein Engineers Design Potential Tool
...r. Alber. Manipulation of coiled coils may also allow scientists to attach specific proteins together. In nature, coiled coils "zip" together two or more subunits of a protein. To take advantage of this function...Proteins Interacting With RNA And DNA Are Surprisingly Similar
...oteinshave the sameshape, a configuration of three coils called alpha helices. Notonly do theyhave the same shape, the proteins attach to RNA and DNA atprecisely the samepoints along one of their coils. A scientific paper detailing the findings was published in theJanuary issueof a British science journal,...Moving DNA Molecules With Magnetic Tweezers
... copper wire, each connected to apower source. The coils are positioned to produce electromagneticfields in...e. At rest,DNA is a long, chain-like molecule that coils itself into theshape of a ball. When one end is pulled by a magnet, the moleculestretches into a nar...Purdue Study Aims To Boost MRI Capabilities
... powerful gradient amplifier assembly and magnetic coils to produce pulsed magnetic fields of greater intensity than can be applied in a commercial magnetic resonance imager. This system, developed at Purdue over two years, will allow the group to manipulate and measure tiny changes in the timing and inten...UW Smogmobile Offers Cleaner, Safer Alternative To Gas Or Electric Cars
...ated fuel tank through a series of aluminum tubing coils and specially designed pipes. Engine exhaust and outside air are circulated around the coils and pipes to gradually warm up the nitrogen from a minus-320 F liquid to an ambient-temperature gas....Non-Surgical Treatment Ends Pelvic Pain In Women
... If the X-rayshows very tightly coiled veins, tiny coils or glue-like liquids are introducedthrough the catheter, plugging the veins. The procedure, which takes less thantwo hours, requires light anesthesia and generally does not requirehospitalization, says Venbrux. Other authors of the paper in...CWRU physicists invent "supershielding" for MRI devices
... positioning an iron barrier or a set of secondary coils outside the maincoil that produces the original unshielded field. In each case, the field is left alive inside where it is needed to do its work. Brown says that Picker International, a pioneer in computerized axial tomography (CAT scans) and magneti...Simulating protein folding from physical laws
...d a structure consisting of a bundle offive spiral coils that matched 80 percent of the structure found by X-raycrystallography. It was the best match of several computer-generated structuresfor the protein submitted to the Third Community Wide Experiment on the CriticalAssessment of Techniques for Protei...New electrical transformers will improve power quality
...nd integrated circuits instead of the heavy copper coils and iron cores of conventional transformers. The work is sponsored by Asea Brown Boveri, an engineering and technology company with headquarters in Zurich, Switzerland. A patent recently was issued for the solid-state transformer, which over the next...Pitt team first to illustrate mechanisms of chromosome missegregation in cancer cells
...h." During normal cell division, coils of genetic material called chromosomes align neatly in the middle of the cell into 23 pencil-shaped pairs of parallel strands called chromatids. At the same time, two centrioles form at opposite poles of the cell. Thread-like microtubules attach ea...Researchers glimpse polio virus as it enters host cell
...article through which the 135S particle throws out coils of protein. These embed in the host cell membrane,...S particle to the host. Once embedded, the protein coils may change their orientation to create pores through which the viral contents may be emptied. The 80...Chemical probe reveals ultrafast movements of DNA proteins
... happens when an strand of DNA coils and folds in upon itself like a crumpled rubber band. Ohio State's probe allowed the South Carolina scientists to measure much smaller movements -- those of the chemical base pairs that make...Magnetic fields may hold key to malaria treatment, UW researchers find
...d safe, Lai envisions rooms equipped with magnetic coils to produce the oscillating field. "It would be very easy. People could come to the room and sit and read or whatever while they're being treated," he said. "Or you could set it up in the back of a big transport truck, then drive from village to vi...BRCA1 cancer gene plays pivotal role in DNA control complex
...nd small proteins called histones and then further coils into a higher order structure called chromatin. Chromatin forms into chromosomes, of which humans have 23 pairs in each cell. The DNA control complex that incorporates BRCA1 is called SWI/SNF. SWI/SNF's role is to remodel chromatin - by uncoiling it ...Common mode of action likely in gene-activation molecules linked to cancers
...istones, which are small proteins around which DNA coils itself to form structures called nucleosomes. Comp...ed and their expression is repressed. When the DNA coils around the histones are loosened, the genes become available for expression. Although scientists ......be harvested in greenhouses simply by using cooled coils to capture it, just like a dehumidifier. There are limits to the dirtiness of the water plants can process, but increase their tolerance to urea, for example, and they could thrive on the colonists' urine. The researchers are also looking to give pl...The world's most powerful NMR spectrometer
... magnet, which consists of several superconducting coils surrounded by an outer dewar containing liquid helium. Atomic nuclei of molecules inside the tube give detectable responses to a radio frequency signal emitted by the inner coil at varying "resonance" frequencies. A typical experiment involves scann...Wistar study offers new support for a 'histone code' theory of gene regulation
...nes are relatively small proteins around which DNA coils itself to create structures called nucleosomes. Co...cessed and their expression is repressed. When the coils of DNA around the histones are loosened, the genes become available for expression. The "histone cod...Required activation 'cascade' identified for p53 tumor-suppressor protein
...ription, and so their expression is repressed. The coils of DNA around the histones must first be loosened to permit gene expression. HATs are enzymes that add an acetyl molecule to the histone, which has the effect of loosening the DNA coils. To further explore HAT activity in relation to p53, Berger and ...