New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...ety of cancers. The research by Pendergast and her colleagues was supported by the National Cancer Institute and...ut of control. In earlier work, Pendergast and her colleagues found that the outlaw BCR-ABL protein plugs into an adaptor protein called GRB-2 to switch on a chai...Tumor Suppressor Gene Located In Liver Cancer Cells
...he testing of a promising new drug. Jirtle and his colleagues are continuing their studies of the M6P/IGF2r by investigating whether this gene also plays a role in the formation of other types of tumors. After four years of study, Jirtle said, "We are at the end of the beginning."...New 'Twist' In Proteins Offers Possible Route To Improved Antibiotics
...ection. In earlier research, Raetz and his colleagues had discovered that the aminoacid sequence of the ... kill the bacteria. At Duke, Raetz and his colleagues are planning experiments in which theyselectively alter various amino acids in the enzyme and then s...Duke Geologists Explore Alternative Way To Measure Ice Age Sea Bottom Temperatures
... Science, Duke University geologist Gary Dwyer and colleagues from Duke and other institutions described how the fossilized remains of marine crustaceans called ostracods seem to provide more reliable measurements of ancient water temperatures than the usual indicators. The usual method involves comparing the r......eered by scientists at Caltech, Ku and his Caltech colleagues demonstrated in 1987 the feasibility of using mass spectrometry to make the kind of measurements demanded by the Zhoukoudian dating project. They achieved a 10- to 100-fold improvement in sensitivity and precision over the radiation-measuring method...Computer Program For Quicker, More Detailed Mapping
...n changed the engine,"said McKusick. McKusick and colleagues modified the original program in steps, graduallyreplacing the very precise, but time-consuming and expensive parts. At everypoint, they evaluated its success to make sure they were not sacrificingaccuracy. "We started out using the off-the-shelf th...Duke Researchers Find Second Gene Linked To Blood Vessel Disorder
...earcher David Johnson, the study's lead author,and colleagues from Duke and from six other research institutions...underlyingcause. Now in two years, Marchuk and his colleagues have linked HHT to twogenes and a potent growth factor, TGF-_. "We've learned a lot in a short spa...Transgenic Rice Plants Resist Insects, Drought And Salt Damage
...sciences at the Rockefeller Foundation, Wu and his colleagues "have made a significant contribution toward meeting world food requirements by demonstrating that biotechnology can be used to enhance the rice plant's ability to defend itself against pests and stresses, without the use of expensive and sometimes d...Southern Pine Beetle Reaching Outbreak Levels In North Florida
...d communities want to avoid. "As one of my retired colleagues has said, we've been setting the table forthe Southern Pine Beetle," Foltz said, "and now it has come to dinner."...Gene Discovery Could Overcome Aluminum Barrier To Higher Wheat Yields Worldwide
...>U.S. Department of Agriculture scientist and colleagues in three other countries have found a gene in rye ...ies of wheat and rye," said Wotecki. Gustafson and colleagues made their genetic discovery by unlocking the mysterious role of protein synthesis in blocking the u...'Juliet' Evades Primate Center Expedition
...uke Primate Center Director Kenneth Glanderand his colleagues said Monday they sighted groups of rare diademed s...pleting the population." And, when Glander and his colleagues exploredthe area where Romeo had been captured three years ago, they found a heavilylogged forest wi...NCAR Scientists Trek To Africa For Biosphere-Atmosphere Chemistry Study
...enging. Early this year, scientist Lee Klinger and colleagues met a truck and trailer that were shipped across the Atlantic; drove them across Cameroon; and then accompanied them on a barge up the Sangha River to the Ndoki site, located near one of Africa's most-remote and best-preserved rainforests. To sample ......ique known as functional MRI (fMRI), Cohen and his colleagues do "brain-mapping" experiments that produce high- resolution images showing what brain sites are active during different kinds of mental activity. fMRI generates a great deal of information quickly (half a gigabyte or more per experiment). In the pas...Cornell Scientists Find Way To Boost Rice Crop Yield -- They'll Walk On The Wild Side
...h said. While examining wild rice, McCouch and her colleagues have been systematically mapping genes of rice varieties and looking for the specific loci or genes -- known as the Quanitative Trait Locus, or QTL -- that would tend to boost production. Before molecular genetics breeders had no way of finding the ...Sea Turtles Have Favorite Oceanic Routes
...he nesting beaches in Costa Rica, Morreale and his colleagues tagged eight female leatherback turtles with small satellite transmitters designed to survive the crushing pressure of the ocean's deep water and buoyant enough to transmit a signal when a turtle reached the water's surface. Attaching the transmitter......dentical and halffraternal --Professor Reznick and colleagues at the Institute forBehavioral Genetics at the Uni...ond year oflife. Professor Reznick and his colleagues -- Robin Corley of theInstitute for Behavioral Genetics and JoAnn Robinson of the PreventionResearch...Two Long-sought Diabetes Gene Found
...fic region on chromosome 12. Last spring, Bell and colleagues mapped NIDDM1, the gene responsible for a significant proportion of diabetes in Mexican-Americans, to one end of chromosome 2. In September, a Scandinavian study indicated that MODY3 may be the same gene as NIDDM2; different forms of the gene, the re...Fast Measurement Technique Reveals Early Steps In Protein Folding
...earchersfirst must unfold them. Gruebele and his colleagues -- graduate students Richard Ballew and JobiahSabelko -- do this by supercooling the proteins in an aqueous solution.Then, to initiate the folding sequence, the solution is heated rapidly bya single pulse from an infrared laser. As the proteins begin......ntists S. Blair Hedges of Penn State and his Cuban colleagues discovered the tiny orange-striped black frog livi...omic conditions typically have teamed with foreign colleagues to carry on their work. "The tropical forests in Cuba are even more fragile and more threatened tha...