Newly discovered protein may be key to muscular dystrophy
...he hallmark of muscular dystrophy, one of the most common genetic diseases. The study was carried out ... said. Duchenne muscular dystrophy, the most common form of the disease, primarily affects boys -- about one in 3,500 male births. It typically begins i...... to circadian rhythms, and for countering the most common circadian problems -- the jet-lag one feels after overseas flights or fatigue when working night shifts. "Identifying a ligand for Rora might help reduce the effects of jet lag," says Sato. The article, "A Functional Genomics Strategy Reveals Ror...Gene linked to cleft lip and palate identified
...e . "Cleft lip and cleft palate are among the most common birth defects in the United States," says Nancy S. Green, M.D., medical director of the March of Dimes, which helped fund the study. "This new finding brings us closer to understanding the multiple genetic factors underlying these very serious birth ...New model can aid in understanding immune system diseases
...nt to study. Such is the case with Epstein-Barr, a common virus that is often harmless but likely contributes to malignancies and autoimmnune disease in people with compromised immunity. A University of Iowa team has engineered a mouse that provides new insights into the virus. The animal model has implica...Study narrows search for genes placing men at increased risk for prostate cancer
...ng genes that may make men more vulnerable to this common cancer. Prostate cancer is the second-leading caus...e collaborative studies like this are increasingly common in complex disorders that have a huge impact on public health, such as cancer, heart disease, diabet...Other highlights in the August 18 JNCI
...Neuroblastoma Prognosis Neuroblastoma is the most common extracranial solid cancer diagnosed in infants and children, but there are few predictors for the disease's prognosis. In a new study of neuroblastoma cell lines and tumor samples, Manel Esteller, M.D., Ph.D., of the Spanish National Cancer Centre in...Progress in breast cancer progression
Breast cancer is the most common cancer among women and the second leading cause of cancer death among women. The prognosis for cancer patients is related to the stage of the tumor. The latter stages are the most deadly as the tumors have become metastatic, meaning they have becom...JCI table of contents, 16 August, 2004
...east Cancer Progression Breast cancer is the most common cancer among women and the second leading cause of cancer death among women. The prognosis for cancer patients is related to the stage of the tumor. The latter stages are the most deadly as the tumors have become metastatic, meaning they have becom...Medication reconciliation, pharmacist involvement vital to reducing medication errors, study finds
...ient harm if continued beyond discharge. The most common discrepancy was complete omission of a medication that the patient reported taking prior to hospitalization. The next most frequent discrepancy was a different dose, route or frequency of medication ordered compared to what the patient was taking pr...Stanford researcher's findings may shed light on common, deadly birth defect
...ft unscathed. The results not only shed light on a common cause of miscarriage in humans, they also help to untangle a medical mystery: why children born with the same genetic disorder can have vastly different symptoms. "Everybody recognizes that in some genetic diseases, one person can be much more severe...5AM Solutions releases Microarray Enterprise Manage(TM) Software
...d to cures. While expression microarrays are now a common genome-scale tool used widely in research, the vast amounts of data created by this technology at distant sites are rarely combined - slowing the progress of medical research. Collaboration and consortia, key elements of the National Institutes of He...Gene duplication allowed pigs to have more babies
...gene duplication is likely to have occurred in the common ancestor of the three animals, around 35 million years ago. This coincides with the climate changes that started in the Oligocene. By consulting the palaeontological record, which contains fossils of pregnant animals, the researchers found that the ...X marks the spot: Vector insertion is viral specific
...iladelphia, PA) - Retroviruses are one of the most common vehicles for delivering therapeutic payloads via gene therapy in animal models of disease and human patients. Viruses integrate into host DNA to replicate, but exactly where they insert themselves has become a topic of increasing importance. This is ...Rare mutations can significantly increase risk factor for heart disease
...epended primarily on the cumulative effect of many common genetic variations, each of which influenced HDL l...aid, collectively, mutations of this type might be common enough to contribute to the variation seen throughout the population. To determine the influence of...Hopkins scientists use blood proteins to detect ovarian cancer
...etect ovarian cancer using three proteins found in common in the blood of women with the disease. Their preliminary studies with the new test suggest a molecular signature exclusive to this deadly cancer, known for its ability to remain undetected and spread quickly. The Hopkins test, described in the Aug...Alcohol-use and depression among pregnant and postpartum women
...on't think that the general public is aware of how common the coexistence of alcohol-use disorders and depression is," said Rina Das Eiden, a senior scientist at the Research Institute on Addictions at the University at Buffalo - SUNY. "People generally think of these problems as being completely separate ...Genes can influence both alcohol consumption and dependence
...and extremely heavy drinking, or some overlap or common causes for each, or the same underlying causes for both. We sought to explore this relationship, which has received little attention in the past because most studies have concentrated on either one or the other." "We have known for some years that...Infant rats eagerly accept high concentrations of alcohol upon first exposure
...tated by consuming alcohol beforehand. It is also common in some parts of Latin America, for example, to place a cotton ball soaked with alcohol on the stomach of a fussy infant, which brings relief in the presence of alcohol's odor, perhaps making it more attractive, and also results in some alcohol intak...Last of known genes identified in complex obesity syndrome
...r characterized by a combination of some otherwise common problems, including obesity, learning difficulties, diabetes and asthma. The identification of the BBS3 gene ends the search for primary BBS-causing genes in families studied for years by a team of scientists from the United States, Canada and the Un...... variation is spelled with either an 'A'--the more common of the two--or a 'G'. Patients with schizophrenia ... two of the 'A' variant. Scientists think the less common 'G' variant may exert a protective effect against the disease. People with schizophrenia and their h...