Cross-species comparison reveals shared features between tumorigenesis and organogenesis
...w and the paper's lead author. Such cross-species comparison provides a powerful new tool for understanding the genetic changes associated with human tumor development. In a developing organ, the pattern of gene expression changes as the individual cells commit to their own specialized functions. By analyzin......t are still largely vegetarian served as an ideal comparison because they carry a different variation of the apoE gene, yet lack human ancestors' resistance to diseases associated with a meat-rich diet. While chimpanzees have a shorter life span compared to humans, they demonstrate accelerated physical and cer...Germ-free transparent fish open new window into gut development
...roup later colonized with normal gut bacteria. The comparison revealed 212 genes with different levels of expression in germ-free fish compared to the other two groups that had been exposed to bacteria. The researchers found 66 zebrafish genes that are analogous to genes regulated by friendly bacteria in the mo...Researchers begin promising new trial to fight colorectal cancer
...nger than those treated with IFL in a head-to-head comparison study. Eloxatin? is manufactured by Sanofy-Synthelabo and Genentech manufactures Avastin?. "The findings from this study have the potential to affect the standard of care for metastatic colorectal cancer," said Howard Hochster, M.D, lead investig...Baker's yeast rises from genome duplication
...duplication, but the evidence remains weak without comparison to a pre-duplication relative. Broad researchers u... method to more species. Typical methods of genome comparison would "miss the genome duplication event if they focus on solely the best match for every gene and e...Genome of first fungal pathogen unveiled
... occurring in a similar gene order. Further comparison of the Ashbya and yeast genomes revealed 300 instances of sequence inversion or movement of a segment from one location to another since the divergence of the two species. The analysis also revealed two copies of the majority of Ashbya genes in the y...Cancer health risk significantly underestimated by EPA's ambient model estimates
...easurements to estimate public health risk. Such a comparison is important in evaluating the validity of ASPEN, which is being used nationally to assess the public health impact of ambient air toxins. The study, "Personal Exposure Meets Risk Assessment: A Comparison of Measured and Modeled Exposures and Risks i...JCI table of contents, March 1 2004
... bone marrow, serum, and plasma of HCL patients in comparison with healthy donors, and active TGF-beta1 significantly correlated with the extent of bone marrow fibrosis and infiltration with leukemic cells. The authors went on to demonstrate that TGF-beta1 significantly enhanced the production and deposition of...DFG establishes 14 new research units
...s forms of cultural and social practice and in the comparison to determine differences and similarities. An interdisciplinary Research Unit at the University of Halle-Wittenberg is examining "The Enlightenment in the Perspective of Modern Esotericism". Its objective is to contrast the historical concept of the ...New study seeks to establish mechanism between areas of the brain and continence
...ts. Because the studied groups were different, no comparison could be done on magnitude of volume of cortical activation or its maximum percent fMRI signal change in activity between monitored maximum contraction and self-reported maximum contraction. Comparison of the incidence of cortical activity in variou...UNC study may improve gene therapy safety
...toxicity effects. However, they wrote, "systematic comparison of their effects upon cells at the molecular level has not been established." In that regard, the new research offers important new and potentially useful information for predicting the safety of gene delivery in people. "The field has advanced so ra...K-State professor to give paper on potential impact of ag bioterrorism
...n would look like and so you can do a side-by-side comparison and make your diagnosis." While the system is designed to detect bioterroristic events, Stack said the recent bovine spongiform encephalopathy, or mad cow disease, outbreak is a great example of how the network can work and respond rapidly to natura...Penguin bones from 'land of fire' rewrite bird's evolution
...d other bones. Details of the bones, and a careful comparison of them to both fossil and modern penguin bones, allowed them to unravel the evolutionary relationships of the new fossil. Clarke says that a larger, more comprehensive study of the penguin family tree is necessary before the full story of early peng...Researchers determine reason for deadly spread of 1918 influenza
... different positions in the 1918 hemagglutinin, in comparison with the Hong Kong protein," said Skehel. "This subtle difference allows the human receptor to bind in an antigenically favorable way." According to Skehel, the hemagglutinin of the current strain of avian flu that has killed people in Asia exposed t...Highlights of Tufts University nutrition research: January 2004
...and 133 Dominican elders, and a neighborhood-based comparison group of 243 non-Hispanic white elders, all aged 60 to 92 years. Dietary patterns were defined by five clusters of food groups: fruit and cereal; starchy vegetables; rice; whole milk; and sweets. They discovered that Hispanics were more likely to co...New study shows Neanderthals were not our ancestors
...itutes the most extensive inter- and intra-species comparison of primate evolution ever recorded. "What the data give us is a robust analysis of a widely representative sample of primates, and provides the most concrete evidence to date that Neanderthals are indeed a separate species within the genus Homo," ...Other highlights in the January 21 issue of JNCI
...ported, randomized controlled trials with suitable comparison groups and additional outcome measures. Gene Mutation Affects Sensitivity of Cancer Cells to Chemotherapy Drugs A research team has found that a specific mutation in a gene critical to folate metabolism alters the sensitivity of colon and breast ...Chimp vs. human DNA: what's in the 1% difference
...ry of humans and chimps. In the most comprehensive comparison to date of the genetic differences between two pri... a treasure-trove of ideas to test by more careful comparison of human and chimpanzee development and physiology," Clark says. The DNA sequencing of the chimpanze...Lifestyle accounts for difference in chimp, human genome
...ry of humans and chimps. In the most comprehensive comparison to date of the genetic differences between two pri... a treasure-trove of ideas to test by more careful comparison of human and chimpanzee development and physiology," Clark says. The DNA sequencing of the chimpanze...Alcohol exposure in pre- and early post-natal stages may cause insulin resistance
...ps were evaluated by ANOVA with Dunnett's multiple comparison test. Insulin values were log-transformed before analysis and values expressed as the mean SEM. P<0.05 were considered significant. Results The researchers noted the following: Animal weight and food intake: All male offspring ...