Simple Chemical Switch Steers Migrating Neurons
... action ofrepulsive factors. For example, MAG, a component of a neuron's protective myelin sheath, isknown to actively block axonal regeneration. The researchers showed thatMAG, which is normally repellent, can become an attractant when cyclicAMP levels are raised. "Since many different inhibitory factors ...Hyperforin Is A Key To St. John's Wort, Researchers Say
...own what may be a keyto St. John's Wort's power, a component called hyperforin, which is now widelyavailable in...uestions remained about the identity of the active component and how it relatesto efficacy. These studies on the extract in MOVANA™ help answer thosequestio...Tightly Controlled Protein Destruction Drives The Cell Cycle
...ansition. Her team recently discovered that an APC component called CDC23binds to cyclin, a protein known to be essential in earlier steps of mitosis,leading to its destruction. According to Holloway, disruptions in the ubiquitinsystem have been linked to a number of human diseases, including colorectal andoth......f the study. In an effort to tease out the component of prion protein that mightactually confer the most crucial distinction in strains--the time it takes forthe disease to develop--the researchers plotted the protease-sensitive componentof the PrPSc versus incubation time and were struck by what Safar...Researchers Grow Healthy Human Placental Cells For Drug Research
.../High Impact Research” program. NIGMS is a component of the National Institutes of Health that supports basic biomedical research....New "Gene Map" Doubles Number Of Genes
... further research." Although gene mapping is one component of the Human Genome Project, it differs from the task of determining the complete DNA sequence of the human genome, which has been much in the news recently. The U.S. government, working with institutions in other nations of the world, has accelerate..."Lab On A Chip" For DNA Testing Invented By U-M Engineers
... expected that the "lab on a chip" will be the key component in simple,low-cost, portable instruments that replace the current technology and make DNAanalysis widely available. The broad availability of simple DNA testing equipment should produce majorbenefits in many fields, including medical diagnostics, for......hysiology of Niemann-Pickdisease, and finds that a component of the myelin sheath is involved in diseasepathogenesis. The other group, a collaboration between people at the NHGRI, inFinland and in Switzerland has combined microarray technology with FISH toexamine the tissues of patients with prostate cancer. ......nt of, and subsequently licensed to Merck, the key component in thefirst genetically engineered vaccine for humans, which was the hepatitis B (HBV)vaccine. In 1987, the company characterized the hepatitis C genome. Currently, Chiron isembarking on a Phase I clinical study for a potentially therapeutic andpr......essively, and hopethat it will become an important component in anti-HCV treatment regimens," saidDr. Ralph Christoffersen, Ph.D., CEO and President of RPI. RPI, located in Boulder, Colorado, was founded to capitalize on the broadpotential of ribozymes for use as human therapeutics and other areas, includingth...Nuts And Oats May Build A Strong Heart
... heartdisease, Albert says alpha-linolenic acid, a component of nuts, may protect theheart by preventing a rhythm disturbance called ventricular fibrillation thatcauses sudden death. When the heart lapses into ventricular fibrillation, itcannot pump blood unless shocked into a normal rhythm with an electrical...Vulnerability To Compulsive Gambling Is Partly Inherited
.... "We were able to estimate the specific genetic component for two of thosegambling behaviors," says Eisen. "One was gambling larger amounts than intended,and the other was repeated efforts to reduce or stop gambling. For those twosymptoms, we found that about half of the gambling behavior was geneticallymed...Sunless Tanning Agents Provide Continuous Sun
...researchers say dihydroxyacetone (DHA), the active component of sunlesstanning preparations, reacts with skin surface proteins to produce pigment thatscreens against UVA, UVB and visible radiation. Although the sun protectionoffered by products containing DHA offers only an SPF of level 3, it offersday-long p...Treatment With IL-2 Plus HAART Markedly Reduces HIV In Immune System "Hiding Places"
... long-term follow-up," Dr. Fauci notes. NIAID is a component of the National Institutes of Health (NIH). NIAIDconducts and supports research to prevent, diagnose and treat illnessessuch as HIV disease and other sexually transmitted diseases,tuberculosis, malaria, asthma and allergies. NIH is an agency of the...SFU Molecular Biologist Pursues 'Promising' New Way To Fight Disease
...Sinfection. "We envision our peptide mimics as one component of a vaccine thatelicits both antibody and cell-mediated immunity -- a vaccine giving us the bestof both worlds."......urvival." The tau protein is also the main component of the abnormal tangles inneurons that, along with amyloid plaques, define Alzheimer's disease. Tautangles are seen in other dementing diseases, too, such as Pick's disease. Priorto this study, however, scientists had been unable to directly associat......tinal, fromdigested rhodopsin, and ethanolamine, a component of the cell membrane. Thecombination of retinal and ethanolamine is precisely what the Columbia chemistsmixed to obtain A2E, indicating they may have mimicked the process that takesplace in the eye. One of the questions the researchers have ...Duke Study Shows Umbilical Cord Blood Transplant Is Viable Treatment For Genetic Disorders
...ng the bone marrow, in essence, replaces a primary component ofthe patient's genetic make-up, doctors said, and thus can cure the geneticdisorder. Early diagnosis has given the daughters of Kim and David Gosey a secondlease on life. Their first daughter, Hannah, was 6 months old when she receivedan un...Cellular Target Of Leprosy, Deadly Viruses Found
...bedded in cell membranes. DG is the cell-surface component of a group of associated proteins known asthe dystrophin-glycoprotein complex. Originally identified by HHMI investigator Kevin Campbell and his colleagues, this complex nestles in the membrane of cells throughout thebody, acting as a receptor for a ......luding epigallocatechin gallate, or EGCg, aprimary component of green tea that has been linked to anti-cancer effects. Their studies, done with cultured cells and with purified NOX protein insolutions, found that EGCg was capable of inhibiting the tNOX activity of cancercells at low doses -- such as those ...