OHSU team discovers compound that lacks estrogen's risks
...siological assay based on testing different (SERM) compounds that acted like estrogen in the central nervous ti...r-causing effects of estrogens," Kelly said. Other compounds tested included the well-known SERMs tamoxifen and raloxifene, used for the prevention and treatment...Candy canes, sugarplums or licorice for Christmas? Only one might stop cancer
...polyphenols that includes the potential anticancer compounds found in green tea and wine. "The precision with which -hydroxy-DHP acts in treating these cancers offers new hope for more effective therapies," said Rafi. Standard chemotherapy kills normal cells along with cancer cells, causing side effects such...Third set of awards are announced under interagency biodiversity program
...he identification and characterization of chemical compounds derived from biological diversity that have potential as therapeutic agents for diseases such as cancer, AIDS, parasitic diseases, drug addiction, mental conditions and heart disease, all of which are of concern to both developed and developing count...Virginia Tech-led group receives third five-year international biodiversity grant
..., in Kingston's group, have also submitted several compounds isolated from Suriname plants to the NCI, which will evaluate them in a 60-cell line panel. "If they find interesting patterns of activity, we will seek to synthesize analogs," Kingston said. Meanwhile, the Missouri Botanical Garden has surveyed plan...SMCM professor discovers cattle hormones that leak into streams and alter fish reproduction
...o understand the possible adverse effects of these compounds on aquatic ecosystem health." They say the priority should be to identify the compounds that altered the fish, and "determine whether they were natural or pharmaceutical in origin." Hormon...Scripps Research receives $3 million anonymous donation
...e changes, the center's scientists hope to develop compounds that will assist in normalizing the brain during a...inical studies at Scripps Research have shown that compounds known as CRF antagonists can block the excessive drinking associated with alcohol withdrawal and pro...Gene interactions control circadian clock in plants, study finds
... sunrise, it can have the necessary photosynthetic compounds prepared in advance," said Somers. "Many of the enzymes and molecular components of photosynthesis have to be re-made daily, as harvesting sunlight and turning it into useful energy is a destructive process. "It's to a plant's advantage to be ready t...Tools from the Human Genome Project reveal a versatile microbe
...nd it can degrade chlorine- and benzene-containing compounds that are often found in industrial waste. It also can remove carbon dioxide, a gas associated with global warming, from the atmosphere. Scientists at Lawrence Livermore National Laboratory used high-tech sequencing machines to sequence the ...Combining various magnetic resonance imaging techniques may help improve breast cancer detection
...maging might be effective in imaging intracellular compounds within breast tumors. If so, this will enable a comprehensive assessment of the tumor environment."...Purdue researchers create templates on retinal tissues
... a pig's retina, making templates out of molecular compounds called peptides that could promote the growth of transplanted healthy cells to treat age-related macular degeneration. Macular degeneration destroys light-sensing cells in the retina. Researchers at other institutions have hypothesized that placing...Changing one gene launches new fly species
...uction of cuticular hydrocarbons -- waxy, aromatic compounds that coat the abdomen of female flies. A male fly, in a romantic mood, strokes the female's abdomen with his feet, which have sensors that recognize specific hydrocarbons, like a perfume. In a previous report, Wu's laboratory found most males with...Yeast helps researchers better understand Parkinson's mystery
...to regulate chemical trafficking and metabolism of compounds called lipids what may be normal functions for this protein. However, when Outeiro studied cells with a slightly higher level of aSyn, he noticed that some of the proteins misfolded and caused others to do the same. The proteins began to form large ...Can EPO prevent loss of brain function in schizophrenia?
...This is particularly appropriate if the beneficial compounds that are suggested are safe. During early episodes...ctive add-on therapy using well-tolerated and safe compounds appears worthwhile to test. The authors decided to use erythropoietin as a first compound with know...Technique kills cancerous cells, leaves healthy cells intact
...on S. Putt manufactured a library of 88 artificial compounds based on the structures of certain natural products. Three of the compounds showed a significant ability to kill cancer cells. Those three were further screened to determine i...Stop to smell the flowers - But do it before they're pollinated
... petunias and snapdragons rely on some of the same compounds and processes to produce scent, these flowers regu...flowers, a variety of substances known as volatile compounds contribute to floral scent, Dudareva said. A volatile compound called methylbenzoate is one of the m...Small-molecule inhibitors of botulinum neurotoxin identified
...unter the threat; thus, identifying and developing compounds that inhibit the neurotoxins is a high priority. I...a high-throughput assay to screen a group of 1,990 compounds known as the NCI diversity set. The molecular properties of this group are predictive of a larger s...Novel sensors help clear the air
...st such as oxides of nitrogen and volatile organic compounds create ground-level ozone. Sensing technologies ar...ousing that is designed to detect volatile organic compounds in harsh subsurface environments," says Nagel. Advanced smart sensors now address environmental safe...Golfing toward a greener environment
... this rubber material - can absorb harmful organic compounds from the environment. The findings, he says, sugge...ine if the rubber layers would filter out chemical compounds carried in the water without affecting the health or quality of the grass. In all experiments, the ...Diet may improve cognition, slow aging, and help protect against cosmic radiation
... form of vitamin A), as well as other minerals and compounds found in food. These nutrients have been shown to help reduce oxidation, a process that can cause damage to cells and may contribute to aging, including the reduced cognitive decline that typically develops with age. Studies suggest that antioxidants......s of retinoids in a laboratory setting. Retinoids, compounds derived from Vitamin A, work by turning on proteins called retinoid receptors, which increase the abundance of a panel of retinoid "target genes." The new study, in the November 7 issue of the Journal of Biological Chemistry, builds on the prior DMS ...