Bigger Biology Tackled Through Keyboards
...nately, a relatively new field of science known as computational biologyis coming of age, according to a review pap...n the field, the paper reviewsthe role of powerful computational tools in studying ecology, genetics andevolution, infectious diseases, and immunology and virology. ...Chemists Compute Answers To The Origin Of Gout
... and electron paramagnetic resonance to verify the computational results. The group has now a much better understanding of how and when the molybdenum is involved in the catalysis. One of their conclusions is that the transfer of a hydroxide ion is involved in the catalysis rather than an oxygen atom as previous...Computer Model Offers New Insight On Bacterial Photosynthesis
... used to solve the structureinvolved sophisticated computational modeling. A similar LH2 structurefrom a different species was reported in late 1995 in the journal Natureby University of Glasgow scientists, who had determined the structure witha different method. Because purple bacteria exist in mud, they have t...Whitaker Awards $6.8 Million For Biomedical Engineering Education
...eveloping a new laboratory and research program in computational tissue engineering. The grant will help set up the...planned. The laboratory will focus its research on computational modeling, including cell- and tissue-level investigations of bone growth and remodeling. The Un...... Vertex used X-ray diffraction data with the aidof computational techniques to construct a high-resolution (2.2 angstroms)electron density map of the complex. The map reveals the nucleic acid-bindingsite, as well as the previously described ATP-binding site that drives theenzyme's activity, amid three distinct st..."A Thousand (And More) Points Of Light" Yield New View Into Cells
...rallel computer processing to handle theprodigious computational tasks involved in the analysis....Scientists Develop New Computer Program To Speed Determination Of Gene Function
... project, thereneeds to be more and more effort in computational biology to extract value fromthe raw DNA sequences and relate it to the function of the 100,000 or so genesand all the medical implications of the variations in each gene," said seniorauthor Dr. Harold "Skip" Garner, associate director of UT Southwes......e and Technology combined X-raycrystallography and computational modeling to identify the structure of aprotein called the two light-harvesting complex in the purple bacteriaRhodobacter sphaeroides. The protein is an aggregate of eight independent butidentical units that form a highly symmetrical ring. A similar ...NSF's Highest Honor For New Faculty Fosters Integration Of Research And Education
...mputationalneuroscience and developing interactive computational teaching tools for use inundergraduate neuroscience courses. Such teaching tools may be used inphysiology and biochemistry courses. Noah F. Gans Professor, The Wharton School University of Pennsylvania Telephone Call Centers: Human Factors in the ......nced Science and Technology, who pioneereda set of computational approaches for simulating molecular dynamics. With a 3-Dblueprint of a molecule, Schulten's simulations produce detailed pictures of amolecule's structural response to external forces. Vogel working with Schulten, his graduate student Hui Lu ...Protein Adultery Revealed!: Mechanism Of Protein Folding Captured In Computer Simulation
...an't be fully carriedout. Now the first successful computational model to capture the process of oneprotein interfe...e folding of even a single protein, andthe lack of computational resources to do so, had inhibited researchers fromattempting robust (reproducible) multiprotein simu......uglyak, anexpert in using powerful statistical and computational tools to tease outgenetic components of common "diseases of civilization" such as cancer and heartdisease. "The technology for doing this - typing potentially thousands of individuals forhalf a million genetic markers - really needs to be developed m...Stanford launches interdisciplinary initiative in the biological sciences
...term, Latombe adds, thebiosciences may inspire new computational schemes and architectures. In such an atmosphere, departmental divisions increasingly are a problem becausethe "action" in biological sciences and in the other disciplines is gravitatingto various interdisciplinary boundaries. "Increasingly, people ...Evolutionary genetic tools trace cancer clone lines
Sophisticated computational tools developed to trace species evolution bycompa...ata began the research after reading about work in computational biology andthinking that the techniques might be applicable to oncology, made contact withTavare, an...Computing device to serve as basis for biological computer
...some is that a "program rule" moleculespecifies a computational step of the computer similar to the way a transferRNA molecule specifies a translation step of the ribosome. The computer is similar to the ribosome in that both operate on two polymerssimultaneously. They function by incorporating incoming mo...... investigations on high-order brainfunctions. The computational algorithms will be incorporated into models ofhuman visual motion perception. Eventually, the computer models might be replicated for robotic devices thatcould mimic motion perception similar to that of a human for various purposes --a robotic device...APS launches new online journal to focus on link between genes and function
...genomics. The Journalencourages publication of new computational approaches, integrative models, and image analysis predictive of gene function. Physiological Genomics will alsofeature invited reviews and perspectives that contribute to enhancing theunderstanding of the scientific approaches and concepts that link......blems in structural biologyand genomics using both computational and theoretical approaches. Dr. Gersteinplans to build a library of protein folds and compare genomes of various pathogenic organisms to create a broader understanding of disease processes atthe level of the entire organism (rather than at the leve...Mechanical forces found to exert larger role in blood vessel health and disease
...e studies they hope to assess the relevance of the computational findingson live animals in addition to the cell culture systems they are currentlystudying. Certain effects of fluid flows on smooth muscle cells become especiallyimportant when these cells are exposed directly to blood flow, for example,during angio......zed a workshop at a recent internationalmeeting of computational biologists where they compared the experimentallygenerated data with the predictions generated by several different softwareprograms. "This kind of competition showed that some programs worked better thanothers, but the important outcome is that peo...