Molecular machine could develop drugs for bioweapons victims
...eting the E-coli ribosomal model was a significant computational challenge given the large number of atoms present ...y suited for large-scale highly-complex non-linear computational problems and is now at the forefront of modeling for the study of ribosomal-antibiotic interactions,...NSF awards $75.6M for plant genome research
...earch. Funded research includes development of new computational tools to compare plant genomes, analysis of genes involved in plant resistance to pathogens, and genes involved in root and fruit development. All the Young Investigator Award recipients have earned doctorates since January 1997 and are at the begin...Researchers elucidate machinery of major anti-cancer target
...d its conformation every time it bound a drug, the computational algorithms for positioning drugs into active sites wouldn't work." Just as they deduced the reaction path of FTase, Beese and her colleagues have now tackled the detailed mechanism of FTase's close cousin, "geranylgeranyl transferase." The differen...NSF awards $37.9 million in grants to study biocomplexity in the environment
...aces of disciplines, such as biological chemistry, computational ecology, and environmental genetics." NSF's Special Competition in Biocomplexity in the Environment: 2002, is the third phase of a multi-year effort. Five subcategories of awards were made: Dynamics of Coupled Natural and Human Systems (CNH), with 1...JGI to decode DNA of destructive plant pathogen
...o enhance the interaction between experimental and computational biology by training postdoctoral fellows, undergraduate students and visiting researchers from minority institutions in a multidisciplinary, team-oriented environment....Finding a 'Holy Grail': simulated and experimental protein folding compares nicely
... using spare time on the volunteer computers. "The computational predictions were in extremely good agreement with our experimentally determined folding times and equilibrium constants," Gruebele said. "For example, our group came up with an average folding time of 7.5 microseconds, while Pandes group came up wit...Sandia pursues biotechnology as new technology focus area
...sensors, electronics, mathematical algorithms, and computational ability. It only makes sense that we do this." A s... already integrating biotech - materials sciences, computational analysis and simulation, physical diagnostic techniques, microfabrication, technology integration - ...Folding@home scientists report first distributed computing success
...tein folding is often considered a "holy grail" of computational biology, he added. "This is an area of hot competition that includes a number of heavy weights, such as IBM's $100-million, million-processor Blue Gene supercomputer project." Folding@home Two years ago, Pande launched Folding@home a distributed com...FIC announces first awards for international collaborative genetics research and training program
...India, with particular emphasis on statistical and computational genomics and molecular genomics. It will generate trained personnel for developing large-scale genetic epidemiological studies in India and will foster collaborations in human genetics research between scientists in India and the United States....Physics tip sheet #29 October 23, 2002
...tris has shown it to sit in the class of difficult computational problems called "NP-hard". That means that there is no efficient way to determine a winning strategy for the game. This happens even if the game is played "offline" with full information, i.e. if the player is given the complete sequence of pieces ah...Scientists produce the script for life
...en genes into a coherent script. We developed new computational techniques, which allowed us to discover the scrip...he synergy that can be generated by biologists and computational experts working together to tackle a systems-level research problem. We are fortunate indeed that su...Field Museum plays key role in massive project to map Tree of Life
...r of birds and AToL investigator. "The conceptual, computational and technological tools are now available to resol...irs for 500 species). A rapidly expanding suite of computational tools will be used to analyze this evidence and determine patterns and evolutionary relationships. T...Cellular pathway includes a 'clock' that steers gene activity
...e cell pathway, said Levchenko, who is a part of a computational biology research team based at the Whitaker Biomedical Engineering Institute at Johns Hopkins. He said drug developers could use the computer model to quickly test how various compounds may affect the cell behavior before launching more time-consumin...Algorithm predicts interactions between proteins whose structures are unsolved
..., the process is greatly accelerated if you have a computational method that helps pinpoint the sites on the interacting proteins that will help scientists discover their role in biochemical pathways. "That's what our method aims to do," he explained. "So, using our supercomputer, we can start to see how the path...A new twist on an age-old problem: Making knee replacements last
...ological loads and speeds to create the first-ever computational wear models for knees, or models that make quantifiable predictions of deterioration of artificial knees. An early version of system came within a few tenths of a millimeter of predicting the wear in an artificial knee that was recovered after a pati...... to reconstruct the tree of life. The conceptual, computational and technological tools are available to rapidly resolve most, if not all, major branches of the tree of life. At the same time, progress in many research areas from genomics to evolution and development is currently encumbered by the lack of a rigo...Secretary Abraham announces next steps for artificial retina project
...ireless device for clinical use and performing the computational modeling of long term retinal stimulation. The Energy Department's Office of Science is funding the artificial retina project at $9 million over three years. The department funds the project as part of its medical applications technology program. ...UCSD research findings for human vs. mouse genome rearrangements
San Diego, CA, Dec.4, 2002 -- A leading expert in computational biology at the University of California, San Diego...igm shift in biology: it is quickly turning into a computational science. UC, and UCSD in particular, have recently invested heavily in bioinformatics development to...The mouse genome and the measure of man
...om 27 institutions in six countries. These include computational biologists at University of California Santa Cruz ...e tremendous efficiencies gained in sequencing and computational technologies in the past few years. Methods for efficient sequencing of large genomes continue to ad......rmacia and an author of the study. "We had a clear computational strategy for how to mine the human genome for protein kinases. And yet we didn't solely rely on automation. We manually went through each one of these sequences to confirm that the mapping process was accurate," he said. Previous efforts to provide a...