New Gene Therapy Technique Results In Efficient Gene Delivery
...ally enter cells, theresearchers introduced a gene conferring resistance to the antibiotic neomycininto the viruses. They added the gene-carrying viruses to the cells and thenexposed the cells to neomycin. To their surprise, the researchers sawcolonies--demonstrating cells had become resistant to neomycin and t......oubleprimary cancers of the colon and endometrium, conferring a significantlyincreased risk for HNPCC. Drs. Millar and Bharati from the Department ofPathology and Laboratory Medicine , Mount Sinai Hospital, Toronto, will discusstheir findings....Genetic resistance to chemically-induced diabetes in mice linked to elevated antioxidant levels
...f this disease.Identification of the gene or genes conferring such remarkable resistance couldlead to therapies to boost natural defenses against diabetes and improvesurvival of pancreatic islet transplants. "These studies in model systems suggest that the extent to which anindividual can detoxify fr...Shedding light on the origin of primate color vision
...been nocturnal for far longer and the polymorphism conferring trichromatic vision has been lost," says Li....AIDS in Africa has potential to affect human evolution, UC Berkeley scientists report
...y caused by an infectious disease acting on a gene conferring resistance is malaria. Over hundreds of years, the...showed that over the course of 100 years, the gene conferring greater resistance to AIDS would increase in frequency from 40 percent of the population to more tha...Enzyme studies at Brookhaven Lab may lead to new antiviral agents
...t strains. As Mangel explains the idea, a mutation conferring drug resistance at one site may alter the physiological functions at the other two sites, because the three sites are interdependent, thereby making drug resistance much less likely to arise. "The adenovirus protease may be a good model system within......sformation of normal cells into malignant cells by conferring upon them the ability for deregulated growth, proliferation and cancer cell invasion. Ras is constitutively active in 30% of human tumors, including almost all pancreatic cancers, one half of colon and thyroid cancers, and one third of lung cancers....Researchers discover strategy that shields HIV from destruction
... the envelope, to uncover different working areas, conferring a strong survival advantage to viral particles that cannot now be "seen" by antibodies, which also change their structure in pursuit of the virus. But the cat (the immune system) cannot keep up with the wily mouse (the virus), Shaw said. The virus ...Study shows molecular analysis of early breast cancer lesions may be key to choosing best treatment
...ntially lethal stage. This suggests that the genes conferring invasive behavior may already be expressed in the pre-invasive stage. Intriguingly, distinct signatures were found in malignant cells extracted from tumors of different cancer grades grade being another measurement by which tumors are classified. ...NIEHS, NTP director receives honorary doctorate
...ne families are now tested for these genes. In conferring the degree, University officials said, There is no stronger advocate for funding genetic research than Olden. He oversaw the development of the Environmental Genome Project, which studies humans varying genetic susceptibility to the environment, as...Pittsburgh researchers engineer and successfully test SARS corona vaccine in animal model
...eaction to the delivered SARS antigens, ultimately conferring protection against the disease. Also, the induced immune reaction appears to be broad: both antibody and cell-mediated immune responses, equally important for protection from viral infections, were detected in the test animals," he said. Dr. Gambott...New insight into control of parental gene expression in eggs
...est candidate molecules that might be critical for conferring imprinting. "We want to identify other paternally-methylated and maternally-unmethylated regions to see if CTCF might be a general protector against methylation," she said. "Further, we've shown that these embryos produce mice with dramatically reduc...Scripps scientists say genetic mutation doesn't protect against HIV and plague
...eft them with CD4+ T cells with no CCR5 receptors, conferring resistance to HIV infection. Later data showed that individuals who were heterozygous for the mutation had lower CCR5 expression levels, less cell-to-cell infection, and brighter clinical prognoses. In order to test the HIV/plague hypothesis, an att...DNA vaccine protects against anthrax
...es that are more capable of neutralizing toxin and conferring protection," says Bell. ...Chicken litter harbors agents that generate antibiotic multi-resistance, according to UGA study
...onment are already equipped with clusters of genes conferring resistance to many antibiotics and can readily exchange these clusters, then the treatment options are limited. "That's what we have today, and the surprising abundance of integrons in the environment is a key as to why we have this problem," s...