Researchers determine genetic cause of Timothy syndrome
... calcium channels that regulate the excitation and contraction of the heart. In defining the precise nature of th...l was known to be important for the excitation and contraction of the heart, but its role in other parts of the body were less clear," said Keating. Studies...Marijuana use could cause tubal pregnancies
...how the CB1 receptor in the mouse regulates muscle contraction to move the embryo down the oviduct. It is not kn...renaline, which in turn stimulates waves of muscle contraction and relaxation in the oviduct, nudging the embryo toward the uterus. Too much or too little of this ...Engineering endurance: The future of the Olympics?
... muscle tissue with the ATP needed to power muscle contraction and sustain ongoing exercise. Which pathway predominates depends on factors like speed, duration, and type of activity, as well as on the availability of oxygen, which fluctuates during activity. Randall Johnson and colleagues have discovered a prote...Muscles are smarter than you think
...ring that our muscles use a 'clever trick'. Muscle contraction in a skeletal muscle fibre in response to a nerve impulse is the result of a complex series of events known as excitation-contraction-coupling. There is a network of tiny tubes in muscle fibre known as the T-system that allow electrical signals, set ...Protective gene may enhance vaccine responses
...Spi2A) can prevent the death of T cells during the contraction phase, resulting in about five times as many memor... were more active in the T cells that survived the contraction phase after exposure to a virus. Then they focused on the likely candidates, genes that interfered ...Access to DNA secrets yields better understanding of genes, possible tool for disease diagnosis
...sential functions, from immune response and muscle contraction to cholesterol and hormone regulation. When DNA is highly compacted, like a closed accordion, it's not as accessible to transcription proteins, and cannot make RNA, said Dr. Harold "Skip" Garner, professor of biochemistry and internal medicine at UT......y regulated during leading-edge extension and tail contraction during the movement of human neutrophilsthe phagocytic blood cells that chase down, engulf, and destroy bacterial pathogens as part of the body's innate immune response. One of the big questions that remained unanswered, however, was how Rac was regu...Endurance exercise found to be equally effective as diuretics in improving cardiac health
...nd Hypertension or high blood pressure during the contraction of the heart is epidemic among older men and women...ensive adults. Reduction of blood pressure during contraction can reduce the risk of stroke and heart failure in hypertensive older individuals. Furthermore, regr...Zebrafish model human development and disease
... contraction; so these results suggest that muscle contraction in the embryonic heart is intimately involved in heart development. Blood flow might also be involved, although the authors find that the heart develops normally even in the presence of pharmacological compounds that abolish blood flow. The characte...'Cardiofunk' mutation: Probable source of congenital heart defects
...that a mutation in a single gene involved in heart contraction interfered with the development of the heart valve...uman embryo, the discovery shows that normal heart contraction is required for normal valve formation, so even temporary glitches in the early heartbeat might caus...UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
...hat one set of chemical reactions resulting in the contraction of the smooth-muscle cells is augmented by a secon...ered that when one of the chemicals in the primary contraction mechanism a protein called calmodulin is in short supply, a second series of chemical reactions ki...New study seeks to establish mechanism between areas of the brain and continence
...sparse data about the central control of voluntary contraction of this sphincter in humans. What is known mostly addresses its contraction response to experimental electrical or magnetic stimulation of the motor cortex, the region of the c...Secondary complications and restoration of function in SCI
...ransit time. In the study, measures that increased contraction of abdominal muscles facilitated defecation; this was especially helpful in participants with higher-cord injury who lacked abdominal muscle control. Although the data need confirmation, results from this study may contribute toward lowering the cost...New systems biology center positions UT Southwestern in vanguard of scientific research
...al life functions, from immune response and muscle contraction to cholesterol and hormone regulation. Dr. Ranganathan and his research group specialize in determining the structure and function of proteins, as well as ways that cells signal each other to carry out certain tasks. Their studies of light-gathering...Researchers reveal calcium transport protein function that regulates heartbeat frequency, strength
...eat and thereby determines the strength of cardiac contraction over many beats. Using so-called "giant membrane patch" techniques together with highly sensitive ion detection techniques, both developed and implemented by Dr. Hilgemann, UT Southwestern researchers were able to determine precisely how NCX1 work...Examining cardiac performance of tunas at the cellular level
...otein SERCA2 are associated with the beat-to-beat contraction of tuna and mackerel hearts. It suggests that there are fundamental differences in the way these fish initiate myocyte contraction, and provides further evidence for the role of the SR Ca2+-ATPase in cardiac function of tunas....JCI Table of Contents, January 15 2004
...ng hormone (CRH). AVP is involved in smooth muscle contraction and its effects are mediated through the binding of AVP to three different receptor isoforms designated V1a, V1b, and V2. V1b mediates vasopressin-stimulated adrenocorticotropic hormone (ACTH) release. To further investigate the roles of V1b, Gozoh ...Scientists identify molecular step that causes intoxication
...here they control neurotransmitter release, muscle contraction and hormonal secretion, the scientists report. The channel may be involved in hormonal or non-behavioral effects of ethanol as well. If alcohol activation of the BK channel is the major cause of intoxication, then artificially activating the chan...Little-studied waves in the heart may be cause of defibrillation failure
...one. This wave then triggers a smooth and orderly contraction of the muscle," Wikswo, the Gordon A. Cain University Professor and Director of the Vanderbilt Institute for Integrative Biosystems Research and Education, said. "In fibrillation, it is as if someone continually throws in lots of rocks at different ......, including transmission of nerve impulses, muscle contraction and activation of genes. Although one type of calcium channel, called the L-type, had been shown to control muscle contraction, the action of the other type, called the T-type, remained largely unknown, said Campbell. The L-channel opens in response ...