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Gene-Altered Mouse May Provide New Insights To Parkinson's Disease, Substance Abuse And Schizophrenia

... much dopamine in the brain's limbic system, which controls emotionand behavior. Conversely, not enough dopamine contributes to clinical depression.Although therapeutic drugs for schizophrenia block dopamine receptors, theyhave limited effectiveness and produce side effects in many patients. "Years of resear...

Automobiles Gain High Technology Noses To Sniff Out Breaches In Air Pollution Laws In Europe Wide Research Project

... monitoring of the extremely precise air pollution controls they have wish to enact into law - laws which will (i.e. California's recent On-board Diagnostic Law - OBDII which requires fault indicators on the dashboard of cars equipped with catalytic converters). Over 1 million ecus have been allocated to th...

How Birds Sing

...ovided the most detailed look yet at how the brain controls singing in the zebra finch, which Margoliash calls the "white rat" of songbirds. Neurobiologists have used them extensively to study brain function. "It doesn't have the most beautiful song ," admits Margoliash. "It sounds like a squeaky door. But i...

Researcher Discovers Key Brain Center For Speech

A key area of the brain that controls the mouth, tongue, larnyx andother intricate movements necessary for speech has been identified for thefirst time by a UC Davis researcher. In a study of 25 stroke patients, neuropsychologist Nina Dronkers foundthat damage to a region known as the "...

Scientists Identify Gene For Sexual Behavior In Male Flies

...howed that the fru gene is: A master gene that controls not only sexual orientation but all, ornearly all, the steps in the male fly's elaborate courtship ritual-- from its first interest in a female through its rhythmic courtingsong, to its attempts to mate. Part of a group of genes that work together to...

Prostate Cancer May Be Predicted 10 Years Before Diagnosis

...l?0.9) compared to men with BPH (2.8ng/ml?0.3) and controls (0.8 ng/ml?0.1.) Free PSA levels were similar among groups at four years before diagnosis. However, the ratio of free to total PSA continuously decreased among cancer cases over the decade before prostate cancer diagnosis. At a time when total and fr...

Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein

...gives us a better understanding of thebreakdown of controls that lead to cancer." Kuriyan heads one of theuniversity's laboratories of Molecular Biophysics. Cells rely on proteins to regulate their differentiation and growth. Mutationsthat alter the normal function of control proteins result in unchec...

Natural Shelters on Leaves House Plant Bodyguards

... use of domatiato induced resistance as biological controls for spider mites in cotton.To jump-start the plant's defense mechanisms, they have previously inducedresistance in cotton plants experimentally with naturally occurring plantchemicals or by briefly introducing mites during the early stages of growth....

A New Biochemical Link Established Between Stress, Sex And Dominance

...e African cichlid fish when a bigger, rowdier male controls a coveted patch of lake-bottom territory. In a study published Aug. 15 in the Journal of Neuroscience , a research team led by Stanford neurobiologist Russell Fernald has shown that continuous high levels of a stress hormone, cortisol, work to pre...

Overfeeding Normal Infant Rats Affects Three Generations: Permanently Changes Basic Metabolism, Interferes With Reproduction

...ated againand they were 12 percent larger than the controls when they were bred to normalmales at 4 months of age. Many of the overfed first generation had difficulty with their ensuingpregnancies and their birth rate was 70 percent of normal rats. The weight pattern reversed itself in the se...

Guidelines For Next Generation Of Environmental Policy

...ric generating stations with appropriatesmokestack controls to replace polluting coal power plants," says ProfessorEsty. He adds that the Multilateral Agreement on Investment, now undernegotiation in Paris by the Organization of Economic Cooperation andDevelopment, offers mechanisms to support global capital...

Researchers Discover New Genetic Risk For Alzheimer's Disease

... changes in the regulatory part of the gene, which controls howmuch APOE protein our cells produce," said Alison M. Goate, Ph.D., associateprofessor of genetics in psychiatry and a lead author of the study. Goate's team at Washington University collaborated with Spanishresearchers, led by Fernando V...

Peutz-Jeghers Disease Gene Identified: Enzyme Loss Causes Polyps And Cancer

...duction. The molecular mechanism by which STK11 controls cellular differentiation in the gastrointestinal tract and in other organs is currently unknown. The search for physiological STK11 substrates will yield further insights into the complicated intracellular network of molecules that preven...

TSRI Scientists Discover Naturally-Occurring Mechanism Involved In Regulation Of Angiogenesis; New Anti-Cancer Therapeutic Agents Are Suggested

...growth toward tumors. The mechanism that controls the delicate balance of biological processesthat tips the scales in favor of blood vessel formation--leading to tumorgrowth--was unclear. Now, the TSRI scientists report that a naturally occurringfragment of an enzyme known as matrix metalloproteinas...

Hormones Found In The Brain May Determine How Much You Eat And Affect Obesity And Diabetes

...in calledthe lateral hypothalamus, the region that controls appetite. After determining that they had the locks (receptors) and keys(ligands) that fit together to begin the intercellular communicationprocess, the investigators tested it on rats. They used catheters toadminister some of the neuropeptides t...

Wistar Scientists Identify New Tumor Suppressor Gene For Breast And Lung Cancer

...that BRCA1 and BAP1 form a complex inthe cell that controls BRCA1's activities, including its deterioration. ...ucts that appear to be part ofa large complex that controls the growth of breast and lung epithelial cells. Mutations in either BAP1 or BRCA1 abolish this compl...

Intake Of Acetaminophen Increases Risk Of Excessive Anticoagulation In Patients Taking Warfarin

...ated with increasedhemorrhage risk -- and 196 were controls with INRs in their target range of 2 to3. Patients were contacted by phone and asked a variety of questions regardingtheir health, diet and medications taken in the weeks before their blood test. The researchers found several factors associated wi...

Prostate Cancer Switch May Yield Map Of Cancer Machinery, Targets For Drugs

...eds no outside stimulation to grow, and escapesall controls -- becoming "androgen-independent" -- to spread throughout the body.This phenomenon was originally observed by McKeehan, and the Duke medical centerresearchers began exploring its molecular mechanism. The three scientists discovered the switc...

Research Reveals Link Between Development And Contamination In Urban Watersheds

... are occurring in spite of morestringent emissions controls and attempts to control urban runoff. "During the past 30 years, since passage of the Clean Air and Clean WaterActs in the early 1970s, efforts have been made to reduce auto emissionsand control pollutants in urban runoff," said Pete Van Metre, USGS...

New Sunspot Cycle To Be Bigger Than Average

...en beneath the photosphere,they are unsure of what controls the dynamo. So what they do is study measurements ofseveral activities related to the sun and look for patterns thatproceed the sunspot cycle. Hathaway and Wilson said these includevariations in geomagnetic indices (like the aa and Ap indices,which ...

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