Two separate controls regulate chromosome copying in yeast
The crucial job of ensuring that just one copy of a genome gets made during cell division turns o...ion and that they normally went away after one DNA copy was made, but we didn't know whether their disappearance was important for controlling the duplicati......leic acid, comes in numerous forms. Each RNA is a copy of a gene, part of the cells DNA (deoxyribonucleic acid). Organisms have thousands of genes that collectively hold information for all the components of an organism. The Dartmouth researchers found 15 new genes in the worm, C. elegans, which all f......ferase enzyme. In vertebrates both specific single copy sequences, like specific protein-coding genes, and... substantially less DNA methylation at both single copy and repetitive sequences. Because the DNA methylation machienery, like the DNA methyltransferases en......h Hospital have discovered that a single defective copy of the gene, Dmp1, is sufficient to drive cancer d...Myc-induced murine lymphoma has even one defective copy of the Dmp1 gene, this genetic mutation is powerful enough to drive tumor progression. The power beh...U-M scientists find gene for low-frequency hearing loss
...searchers discovered that children who inherit one copy of the mutated gene called WFS1 gradually lose their ability to hear low-frequency sounds. The hearing loss becomes more severe over time, and eventually hearing aids are required. Patients with different types of mutations affecting both copies of t...Gene triggers stem cell differentiation in the intestine
...g mouse embryos. They first examined mice with one copy of the functional Math1 gene, along with the stain-producing gene, to determine which cells expressed Math1 . To our total surprise, we could not detect expression of the gene in the nervous system of the gut, but instead found it in the intestina...Researchers identify gene required for marking DNA as having come from the mother
...ng silences genes in offspring, allowing the other copy of the gene to be expressed. Researchers have repo...sed genes that are normally not expressed from the copy inherited from the mother. The product of the Dnmt3L gene does not appear to actually add the methyl...Gene therapy corrects sickle cell disease in mice, Science authors report
... percent of their red blood cells. "Usually when a copy of a new gene lands in the genome this way, it is strongly influenced by its surroundings, and often gets silenced. But when the expression level is very high, and spread evenly through the cells, as it is in the case with lentiviral vectors, the gen...Protein study suggests ways to help humans thwart viruses
...ing viruses that use a unique production method to copy and insert their genetic material into a host cell. Human cells also contain specialized receptors for retrovirus entry, Sanders says. "Such receptors are often very specific," he says. "We know, for example, that people who don't have the receptor f...Tiny molecular change inactivates tumor suppressor gene in neurofibromatosis
...The first hit comes when a person is born with one copy of the gene already mutated to cause the disease, ...linical manifestations of NF only after the second copy of the gene was hit. The faulty RNA editing seen by Davidson could provide that second hit. When a ......the 18 study participants, 13 possessed one mutant copy of the GNAS1 gene. The prevalence of the GNAS1 mutation was high enough to implicate the gene as a major cause of POH, though other factors may contribute, researchers concluded. Patients diagnosed with POH develop spontaneous bone fragments under th...Fly cells on the move may reveal clues to cancer metastases
... Before dividing, the cells each have one regular copy and one abnormal copy of the gene of interest, and during the process of dividing, they copy both. However, thanks to th...Common variation of 'klotho' gene associated with human life expectancy
... of which alter the protein's sequence. Because a copy of each gene comes from each parent, people might ...ent of the African-American population carries one copy (which confers protection against malaria). While having two copies of the klotho variant was assoc...2002 Ocean Sciences Meeting - Media Advisory 1
...equest from the form below. (Others will receive a copy in the Press Room.) The Press Registration Form is available online at http://www.agu.org/sci_soc/02OSPress_Reg_Form.shtml . The form, available in two versions, may be submitted online, returned by email, or printed and faxed or mailed to AGU. Ema...Proceedings available for conference on sex and gene expression
...ions to sex differences in mammals. To obtain a copy of the proceedings, contact Sarah Gevers, Society for Womens Health Research, at 202-496-5015....Media Advisory 2 - 2002 Ocean Sciences Meeting: press conferences scheduled
...equest from the form below. (Others will receive a copy in the Press Room.) The Press Registration Form for easy online submission is available at http://www.agu.org/sci_soc/02OSPress_Reg_Form.shtml The form is also available there in a version that may be submitted by fax, email or by post. Email addres...Growth factor receptor signaling critical to intestinal tumor development, studies show
... just failed to progress. Humans who inherit a bad copy of the Apc-Min gene can develop hundreds of tumors throughout their intestinal tracts, he said. That illness, however, represents only about 1 percent of human colon cancer cases. Mice with the waved 2 mutation have wavy hair and curly whiskers but a...UK researchers shed new light on a cause of recurrent miscarriages
... of women with a similar history but with a normal copy of the gene. For women with the rogue gene who had a history of late miscarriage only one out of nine had a live birth compared with 22 out of 45 of the women with the normal gene. The research was carried out by teams from the Department of Reproduc...Water lily may provide a 'missing link' in the evolution of flowering plants
...e nourishing tissue is haploid containing a single copy of each chromosome. The question of how endosperm originated, in an evolutionary sense, has perplexed biologists for over a century, states Friedman. Williams and Friedman focused on the water lily family because fossil records and recent molec......e 55 percent of human cancers containing a mutated copy of the p53 gene no longer possess the protective ability to kill off harmful cells. "We might be able to reinstate the mechanism of cell death in cancer cells so that they kill themselves," says Steller, who heads the Strang Laboratory of Apoptosis ...