Tag: "copy" at biology news
Discovery Of Mechanism Causing Colon Cancer
...ctivity was diminished by introducing a nonmutated copy
of the tumor-suppressor APC gene into colon cancer cells. The "good" APC lowered beta-catenin levels, stopping the abnormal stimulation of the cyclin D1 gene. In another experiment, the scientists introduced an adhesion molecule called cadherin into...
University of Pittsburgh Medical Center performs first in vivo gene therapy for hemophilia A
...treatment for thedisease by supplying a functional copy
of the FVIII gene to the body. "Our hope is that this in vivo therapy will produce enough FVIII proteinto protect patients from spontaneous recurrent bleeding and thereby avoid someof the chronic disabilities associated with the disease," ad...
Genetic testing of pregnant women with liver illness could save infant lives
... that a baby with thedisorder needs to inherit one copy
of the defective gene from each parent inorder to ...e disease. A mother who carries just one defective copy
ishealthy until she becomes pregnant with a baby who has inherited the mutatedgene from both parents...
Inherited deafness studies may affect genetic counseling
...nfants were not deaf because they carried only one copy
of the defectivegene. (Two mutant copies of such a "recessive" gene are required to causegenetic disease.) Overall, the researchers found that about 3percent of the infants had some type of sequence variation in the GJB2 gene. But the incidence of ...
For DNA, it's all about fitting in
...bases must fit together for a polymerase enzyme to copy
them.Shape brings fidelity to the process." The f... unravel theoperation of polymerase enzymes, which copy
DNA. The Nature paper is the latest in a series of publications and patentsin which Kool des...
Target for cystic fibrosis drugs found
...t; to have CF, children needto inherit a defective copy
of the gene from each parent. The diseaseaffects 30,000 Americans and is most common among whites, where anestimated 1 in 20 carry the mutation. The research was supported by grants from the National Institutes of Healthand the American Lung Associat...
NYU scientists discover gene for a dementing brain disease
...tary and autosomal dominant, meaning that only one copy
of a mutated gene was needed to cause the disorder and that males and females were equally affected. The advent of more sophisticated protein and DNA sequencing techniques as well as the availability of gene databanks allowed the researchers to iden...
Scientists target microbe with sleeker antisense agent
...echnology, where scientists create a complementary copy
of a strand of RNA inan attempt to knock out a specific RNA molecule from the organism Pneumocystiscarinii. This fungus is an opportunistic pathogen that lives dormant in thelungs of healthy individuals, but flourishes in people with impaired immunes...
University of Pittsburgh team finds gene that increases risk of oteoporotic fractures
...he investigators found that women withat least one copy
of the APOE-4 allele were twice as likely to suffer hip andwrist fractures as those women with either APOE-2 or APOE-3 alleles. Women withthe APOE-4 allele and additional risk factors were even more likely to sufferhip and wrist fractures. "The corr...
Gene therapy trial using cold virus to begin at UK
... The goal of gene therapy is to deliver a correct copy
of themutated gene directly to the nucleus of the ...e called p53. Data indicate that if you provide a copy
of aworking p53 gene to a cell that has a malfunctioning p53 gene, growth of a tumorcan be slowed. ...
DNA: A sloppier copier
...cator of DNA. While the other threeenzyme systems copy
and reproduce information-carrying sequences of the chemicalbases in the DNA alphabet with an error rate of fewer than one mistake permillion bases, the newly discovered enzyme is about 100 times more error-prone. Second, pol V's structure is quite ...
UI researchers advance potential, potent way to stimulate human immune system
[Editor's note: To receive a copy
of the research article mentioned in this newsrelease, please call David Schneier, media assistant, at the National Academy ofSciences at 202-334-2138. To interview Arthur Krieg, M.D., before Aug. 4,please contact Becky Soglin. From Aug. 4 - 6 Dr. Kr...
Cinnamon is lethal weapon against E. coli O157:H7
... may contain harmful microorganisms. For a copy
of the study presented at IFT's Annual Meeting, contactAngela Dansby at 312-82-8424 x127 or via e-mail at email@example.com ....
IFT experts inform and caution consumers about dietary supplements
...sons of different genders and ages." For a copy
of IFT's summary on dietary supplements, contact AngelaDansby....
Images of enzyme suggest way to improve DNA sequencing
St. Louis, Aug. 16, 1999 -- Like a temperamental copy
machine, the mostcommonly used enzyme in DNA seque...etters, called nucleotides, in DNA. It uses Taq to copy
segments of DNA intochains of different lengths. Because Taq comes from a bacterium, Thermusaquaticu...
Rescuing brain cells in stroke patients from the brink of suicide
...tant role in tumorcells, where HIF1a and a mutated copy
of p53 help cancer cells survive in placesin the body where oxygen is in short supply, like the inside of large tumors. In the brain, the Rochester team found that both HIF1a and p53 play arole in convincing stressed cells to commit suicide. ...
Mountain Lake Hotel places environmental book in rooms
...that the source of the essay be acknowledged and a copy
of the re-publishedessay be sent to his publisher, Elkhorn Press in West Virginia. Why would a world-renowned geneticist give away his essays and books? ForWallace, it is part of a life's mission: to get people to realize that savingthe world's envir...
Learning how organs tell left from right
...f the heart and lungs. Humans with one defective copy
of the Pitx2 gene have a constellationof problems called Rieger syndrome, the signs of which include irregularlyshaped eyes, lack of tooth growth, craniofacial deformities, and, more rarely,problems with growth hormone production. Rosenfeld's tea...
Roundworms provide clues to human kidney disease
...ov-1's importance in mating by injecting a healthy copy
of the gene into mutantmales. Mutant males who received the lov-1 gene mated normally. Theresearchers also found that only male sensory neurons vital to vulva locationcontained the protein encoded by lov-1 , further verifying the protein'srole i...
Mutation in PTEN gene can cause cancer and autoimmune disease
...a. and lymphoma. The inherited inactivation of one copy
of the PTENgene also results in three syndromes as...y embryonicdeath. Mice with a mutation in one PTEN copy
(PTEN+/-) were found to have a highincidence of tumors. The most commonly occurring tumors were canc...
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