Tag: "copy" at biology news

Finding a model, finding a cure

...a1, and the fact that mice with only one defective copy of Brca1 did not develop tumors. Dr. Efstratiadis and colleagues modeled their experimental approach after a human breast cancer patient who had inherited homozygous mutations in Brca1 that presumably led to the production of a shortened, or truncat...

'Silent' DNA speaks up for the first time

...e normal frequency. Messenger RNA (mRNA) is a copy of the genes DNA that departs from a cell nucleus to transport genetic information. The researchers discovered that the enzyme responsible for producing mRNA is present even on the silent genes. The process that makes some genes silent could its...

Researchers find first gene that increases risk of Crohn's disease

...ts have the altered form of the gene. Having one copy doubles the risk of Crohn's disease. Having two copies increases the risk 15 to 20 fold. The discovery is a good example of the benefits to be expected from the completion of the Human Genome Project. Nuez, a specialist in programmed cell death, w...

Dopamine-dampening gene linked to prefrontal inefficiency, schizophrenia

...he research team. Brain activity of those with one copy of each variant was more efficient, while activity of siblings who inherited two copies of met showed the highest brain efficiency, on average. Among 104 pairs of parents studied, the investigators discovered that the val form of COMT was transmitte...

UF researchers reverse metabolic disorder in mice

...rmless adeno-associated virus to contain a healthy copy of the gene, known as PAH. The scientists injected the modified virus into mice that have a gene defect similar to that found in people with PKU. In treated male mice, the gene therapy resulted in sharp reductions of phenylalanine, to levels conside...

Copper is crucial for embryonic deveopment, say U-M scientists

...ce to see what would happen to mice without either copy of the Ctr1 gene. Of 378 mouse pups born, however,..., and that the presence of at least one functional copy of the Ctr1 copper transporter gene is essential for normal embryonic development," Thiele says. "In...

Scientists share multidisciplinary discoveries at 'Earth System Processes'

...in registration desk to receive a name badge and a copy of the program book with abstracts. Ann Cairns and Ted Nield will operate an onsite newsroom in Ochil 1, Edinburgh International Conference Centre, Monday, June 25, through Thursday, June 28. Newsroom hours of operation will be 8:00 a.m.-6:30 p.m. da...

From flies to humans-ancient gene may be involved in male infertility

...Xu, to treat the condition by introducing a normal copy of the gene into the testes through a nontoxic vector, where it could then replicate. The testis, unlike brain or heart, is located outside the main human body, limiting the possibility that the gene therapy approach would damage other tissues of the...

Scientists decipher "fail-safe" system that limits gene copying in cells

...n the gene copying process as soon as one complete copy is made. The discovery, published in the journal Nature, involves a fail-safe system of overlapping controls requiring that three separate chemical processes be reversed before the genes can be re-copied - a highly unlikely series of events, and ther...

Ohio State genome map

... two teams, think of the genome as a copy of James Joyce's lengthy novel... Project would then resemble a copy of Ulysses that lacked all punctuation and spacing. Each of this book's chapters...

BioMed Central to deposit e-journals with the British Library

...ilable on demand for libraries that require a hard copy of the BioMed Central research articles. All these initiatives, combined with the policy of promoting self-archiving by authors, means that all research articles published on BioMed Central will be permanently accessible and searchable in multiple ar...

AAAS letter to President Bush

...as well as scientists. We are pleased to enclose a copy of the report. Among thereport's key Findings and Recommendations are that "Public and private research on human stemscells derived from all sources (embryonic, fetal, and adult) should be conducted" and that"Federal funding for stem cell research is...

Eating transgenic sausages

... The pigs had been genetically modified to carry a copy of the rhodopsin gene, which is involved in eye function. Philip Collis, a biosafety officer at the university, says it is unlikely the rhodopsin gene could have made the meat dangerous. If there was any concern, says Collis, it's that the pigs had...

UC Davis' first cloned calf born, succumbs three days later

...tually, the resulting embryo -- which is a genetic copy of the animal that donated the nucleus -- is transplanted into a surrogate mother. The cloning research will continue at UC Davis with a half-dozen other cows now in the very early stages of pregnancy with cloned embryos. Calves resulting from those ...

NIMH scientists discover new details of HIV infectious process

...ering a human cell, the HIV RNA manufactures a DNA copy of its RNA, which then gets integrated into the human cell's DNA. After this integration, the viral DNA acts very much like a normal human gene, but rather than making proteins that are essential for human life, it makes new virus particles. Retrovi...

Genetic mutation influences spread of AIDS; African population lacks mutation

... Kirschner. "Those with one mutated and one normal copy can be infected, but they carry lower levels of th...ection due to lower viral loads in people with one copy of the mutated gene," Kirschner says. Since HIV eventually kills its human host, the number of ind...

Molecular structure could advance understanding of human disorders

...ndshake, to form what is called a heterodimer (one copy of CCS and one of SOD). Once joined, a long coil or arm swings down from the metallochaperone to the copper-binding site on the target protein, poised to deposit the copper. Once the copper has been delivered (although copper was not actually used in...

DNA transcription is tuned to specific cells

...ched off in knockout mice that lacked a functional copy of the TAFII105 gene. The TAFII105 protein is one of a family of TAF proteins that are subunits of a large complex called the transcription factor TFIID. "When TFIID and all its associated factors were discovered ten years ago, we found it in every c...

Next-generation AIDS vaccine for healthy individuals being tested for safety, tolerability at UC Davis

...tion.The HIV-1 gag DNA vaccine includes a man-made copy of one of the genes from HIV, which will make an i...pe 5 HIV-1 vaccine also contains the same man-made copy of the HIV-1 gene but uses a defective, non-infectious respiratory virus (adenovirus) as a backbone....

NASA unveils spectacular suite of new global data products

... with lands, oceans and life on our world. Another copy of the MODIS instrument will fly aboard Aqua in spring 2002 with an afternoon equatorial crossing to capture the daily variability of the Earth system. According to Land Group Leader Chris Justice, MODIS is the first space-based sensor that enables s...

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